<i>In Vitro</i> Anti‐Inflammatory Activity of Selected Oxalate‐Degrading Probiotic Bacteria: Potential Applications in the Prevention and Treatment of Hyperoxaluria

Giardina, Silvana; Scilironi, Cristina; Michelotti, Angela; Samuele, Alberta; Borella, F; Daglia, Maria; Marzatico, Fulvio

doi:10.1111/1750-3841.12344

Cited by 43 publications

(26 citation statements)

References 39 publications

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“…Probiotic strains, studied in this work, were chosen exactly based on their immune-modulatory activity. In vitro efficacy of L. acidophilus LA-14 to modulate the human anti-inflammatory immune response has previously been investigated [ 28 ]; there is a preliminary evidence that probiotic supplementation of L. casei Shirota improved immunological parameters and reduced key inflammatory cytokine markers [ 29 ]. L. lactis NCDO 2118 has been used in the treatment of inflammatory bowel disease (IBD), since it was able to reduce IL-1 β -induced IL-8 secretion in Caco-2 cells [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

Probiotic Cell‐Free Supernatants Exhibited Anti‐Inflammatory and Antioxidant Activity on Human Gut Epithelial Cells and Macrophages Stimulated with LPS

Marco

Sichetti

Diana

et al. 2018

Evidence-Based Complementary and Alternative Medicine

196

121

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The incidence of inflammatory bowel disease is increasing all over the world, especially in industrialized countries. The aim of the present work was to verify the anti-inflammatory activity of metabolites. In particular, cell-free supernatants of Lactobacillus acidophilus, Lactobacillus casei, Lactococcus lactis, Lactobacillus reuteri, and Saccharomyces boulardii have been investigated. Metabolites produced by these probiotics were able to downregulate the expression of PGE-2 and IL-8 in human colon epithelial HT-29 cells. Moreover, probiotic supernatants can differently modulate IL-1β, IL-6, TNF-α, and IL-10 production by human macrophages, suggesting a peculiar anti-inflammatory activity. Furthermore, supernatants showed a significant dose-dependent radical scavenging activity. This study suggests one of the mechanisms by which probiotics exert their anti-inflammatory activity affecting directly the intestinal epithelial cells and the underlying macrophages. This study provides a further evidence to support the possible use of probiotic metabolites in preventing and downregulating intestinal inflammation as adjuvant in anti-inflammatory therapy.

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Section: Discussionmentioning

confidence: 99%

Probiotic Cell‐Free Supernatants Exhibited Anti‐Inflammatory and Antioxidant Activity on Human Gut Epithelial Cells and Macrophages Stimulated with LPS

Marco

Sichetti

Diana

et al. 2018

Evidence-Based Complementary and Alternative Medicine

196

121

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“…[6][7][8][9] In particular, Lactobacillus plantarum exhibits various biological effects including antitumour, anticoagulant, antiviral, immune modulatory and anti-inflammatory, antidiabetic and antioxidant or free radical scavenging activity. [10][11][12][13] We reported that L. plantarum L67 isolated from infant faeces has a high survival rate at low pH values.…”

Section: Introductionmentioning

confidence: 99%

The proteins (12 and 15 kDa) isolated from heat‐killed Lactobacillus plantarum L67 induces apoptosis in HT‐29 cells

Song

Lim

2015

Cell Biochemistry & Function

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A number of scientific studies have revealed that Lactobacillus strains have beneficial bioactivities in the gastrointestinal tract. In this study, the production of intracellular reactive oxygen species (ROS) and the amounts of intracellular calcium, protein kinase C activity, cytochrome c, Bid, Bcl-2, Bax and the apoptosis-mediated proteins [caspase-8, caspase-3 and poly ADP ribose polymerase (PARP)] were evaluated to understand the induction of programmed cell death in HT-29 cells by Lactobacillus plantarum L67. The results obtained from this study indicated that the relative intensities of the apoptotic-related factors (intracellular ROS and intracellular calcium) and of apoptotic signals (Bax and t-Bid) increased with increasing concentrations of the membrane proteins isolated from heat-killed L. plantarum L67, whereas the relative intensities of cytochrome c, Bcl-2, caspase-8, caspase-3 and PARP decreased. This study determines whether proteins (12 and 15 kDa) isolated from heat-killed L. plantarum L67 induce programmed cell death in HT-29 cells. Proteins isolated from L. plantarum L67 can stimulate the apoptotic signals and then consequently induce programmed cell death in HT-29 cells. The results in this study suggest that the proteins isolated from L. plantarum L67 could be used as an antitumoural agent in probiotics and as a component of supplements or health foods.

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“…Uric acid stones are formed due to low urine output, excessive intake of proteins, especially red meat. These form in acidic urine and are not visible in a plain X-Ray (Giardina et al, 2014).…”

Section: Introductionmentioning

confidence: 97%

Advantages of Herbal Over Allopathic Medicine in the Management of Kidney and Urinary Stones Disease

Nimesh¹,

Ashwlayan

Rani³

et al. 2020

Borneo J Pharm

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Kidney and urinary stone disease (Nephrolithiasis and urolithiasis) are the condition where urinary stones or calculi are formed in the urinary tract. The problem of urinary stones is very ancient; these stones are found in all parts of the urinary tract, kidney, ureters, and the urinary bladder and may vary considerably in size. It is a common disease estimated to occur in approximately 12% of the population, with a recurrence rate of 70-81% in males and 47-60% in females. The treatment of kidney and urinary stone diseases such as a western (allopathy) medicine and surgery is now in trends. However, most people preferred plant-based (herbal) therapy because of the overuse of allopathic drugs, which results in a higher incidence rate of adverse or severe side effects. Therefore, people every year turn to herbal therapy because they believe plant-based medicine is free from undesirable side effects, although herbal medicines are generally considered to be safe and effective. In the present article, an attempt has been made to emphasize an herbal therapy is better than allopathic therapy for the management of the kidney and urinary stone disease.

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In Vitro Anti‐Inflammatory Activity of Selected Oxalate‐Degrading Probiotic Bacteria: Potential Applications in the Prevention and Treatment of Hyperoxaluria

Abstract: The oxalate-degrading activity of some probiotics and their capability to modulate the release of inflammation mediators could be exploited as a new nutraceutical and therapeutic approach for the treatment of oxalate accumulation and the related inflammatory state.

Cited by 43 publications

References 39 publications

Probiotic Cell‐Free Supernatants Exhibited Anti‐Inflammatory and Antioxidant Activity on Human Gut Epithelial Cells and Macrophages Stimulated with LPS

Probiotic Cell‐Free Supernatants Exhibited Anti‐Inflammatory and Antioxidant Activity on Human Gut Epithelial Cells and Macrophages Stimulated with LPS

The proteins (12 and 15 kDa) isolated from heat‐killed Lactobacillus plantarum L67 induces apoptosis in HT‐29 cells

Advantages of Herbal Over Allopathic Medicine in the Management of Kidney and Urinary Stones Disease

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