<i>In vitro</i> anti-influenza virus effect of total flavonoid from <i>Trollius ledebouri</i> Reichb

Liu, Yongping; Ji-ming, Tong; Tong, Ying; Li, Ping; Cui, Xiaolan; Cao, Hongbao

doi:10.1177/0300060517750284

Cited by 13 publications

(5 citation statements)

References 19 publications

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“…The use of herbal medicine has been accepted in many countries, including regions with improved healthcare systems [ 60 , 61 ]. Most herbal medicinal herbs are inexpensive and have been shown an anti-influenza activity in long-term practice [ 62 , 63 ]. Herbs are rich in biologically active compounds, including phenols, flavonoids, flavonoids, and flavanols.…”

Section: Resultsmentioning

confidence: 99%

“…In the CoMFA model, the q 2 is 0.62 with a standard error of estimate of 0.093 and r 2 is 0.973 on the training set. All these researches show a well predicted effect of the compounds, but they are generally focus on only one or two types of derivatives, such as sialic acid analogs and resveratrol derivatives, and the currently known NAIs also include cyclohexene derivatives, cyclopentane derivatives, benzoic acid derivatives, pyrrolidine derivatives, flavonoid analogs, and caffeic acid derivatives [ [20] , [21] , [22] ]. This will lead to a result that the model is only suitable for these derivatives, and it is difficult to get a good prediction effect once the structure of test compounds are different from the training set for modelling.…”

Section: Introductionmentioning

confidence: 99%

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2D-SAR, Topomer CoMFA and molecular docking studies on avian influenza neuraminidase inhibitors

Niu

et al. 2019

Computational and Structural Biotechnology Journal

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Avian influenza is a serious zoonotic infectious disease with huge negative impacts on local poultry farming, human health and social stability. Therefore, the design of new compounds against avian influenza has been the focus in this field. In this study, computational methods were applied to investigate the compounds with neuraminidase inhibitory activity. First, 2D-SAR model was built to recognize neuraminidase inhibitors (NAIs). As a result, the accuracy of 10 cross-validation and independent tests is 96.84% and 98.97%, respectively. Then, the Topomer CoMFA model was constructed to predict the inhibitory activity and analyses molecular fields. Two models were obtained by changing the cutting methods. The second model is employed to predict the activity (q2 = 0.784 and r2 = 0.982). Molecular docking was also used to further analyze the binding sites between NAIs and neuraminidase from human and avian virus. As a result, it is found that same binding Total Score has some differences, but the binding sites are basically the same. At last, some potential NAIs were screened and some optimal opinions were taken. It is expected that our study can assist to study and develop new types of NAIs.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

2D-SAR, Topomer CoMFA and molecular docking studies on avian influenza neuraminidase inhibitors

Niu

et al. 2019

Computational and Structural Biotechnology Journal

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“…89 Tanshinone ⅡA inhibits Tat-induced Transactivation of LTR HIV-1 depending on the AMPK-Nampt pathway so that it can be developed into a new anti-HIV agent, 90 oleanolic acid inhibits HIV-1 replication by inhibiting HIV-1 protease activity in vitro, 91,92 and maslinic acid has potent inhibitory activity against HIV-1 proteases. 93 Ladanein Anti-HCV hepatitis C virus (HCV) activity 83 Sinensetin -Treatment of influenza disease with excessive inflammation 31 -Inhibitors of SARS-CoV-2 Guanine-N7 Methyltransferase (in silico study) 77 Cirsimaritin -Inhibitors of COVID-19 main protease (in silico study) 78 -Anti-influenza virus 95 Phenolic Acid 96,43,97,98 Rhamnazin Anti-HCV hepatitis C virus (HCV) activity 99 Rosmarinic acid -Anti enterovirus 71 (EV71) 29,30 -Potential inhibitor of COVID-19 (in silico study) 32,33,73 -Reduces the mortality of mice infected with the Japanese encephalitis virus (JEV) 34 -Inhibit hepatitis B virus replication 36 Caffeic acid -Anti-herpes simplex virus type 1 54 -Inhibition influenza A virus multiplication in vitro 67…”

Section: Anti-human Immunodeficiency Virus (Hiv)mentioning

confidence: 99%

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2021

TJNPR

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pharmacological activities in vitro and in vivo and are part of the plant chemical defense mechanism. 38 Flavone polymethoxy has an influence on biochemical processes and plant physiology, has activities as antioxidants, enzyme inhibitors, anti-allergic, anticarcinogenic, antiviral, antiproliferative, and antiinflammatory. Sinensetin is a very important polymethoxy and bioactive product with various biological activities such as reduces pain, anticancer, antifungal, antitumor and antibacterial. 39 Eupatorin has pharmacological activity inducing apoptosis, vasodilators, antiinflammation, inhibitor P450, and antineoplastic. 40 Rosmarinic acid was isolated from many species of Lamiaceae and Boraginaceae and identified as one of the active components of several medicinal plants. 41 In 1958 Scarpati and Oriente began to isolate rosmarinic acid from Rosmarinus officinalis (Lamiaceae). Rosmarinic acid has various biological activities that make it an attractive material for the pharmaceutical, food, and cosmetics industries. Rosmarinic acid pharmacological activities tested in vitro are antioxidant, anti-inflammatory, antimutagenic, antigenotoxic, cytotoxic, and antimetastatic antiangiogenic, antimicrobial, and immunomodulatory. 42 Qualitative Analysis of Compounds in Orthosiphon aristatus (Blume) MiqQualitative of the Orthosiphon stamineus with UHPLC -ESI-QTOF-MS detected 61 compounds, 52 chemical structures can be identified to provide reference data for efficient separation and the idea of identifying secondary metabolites in other plants of the same genus. The compounds are six diterpenes, 26 phenolic acids, five tanshinones, four fatty acids and 11 flavonoids. Among these compounds, the sinensetin, rosmarinic acid, danshensu, caffeic acid and eupatorin are the main secondary metabolites. 43 Rosmarinic acid and sinensetin which are the main componen of O. aristatus have potential as antiviral agent. 43 The O. aristatus are divided into three varieties, namely white, white-purple and purple, based on the flower colour (Figure 1). 44 While nine compounds that have been successfully separated but have not been successfully identified, further studies are needed by comparing spectrum data and fragmentation patterns with literature. Guo and the team (2019) also reported compounds that have never been published in previous research or reviews. 26,37,44,45 The newly

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“…Polyphenols, which mainly include flavonoids and phenolic acids [3], are present, in high abundance, amongst the genus Trollius (including T. chinensis and T. ledebouri), and are responsible for the antiviral, antimicrobial, antioxidant activities associated with these plant species [4,5]. Previous research had demonstrated that specific polyphenols impede cancer cell proliferation [6].…”

Section: Introductionmentioning

confidence: 99%

Extensive Profiling of Polyphenols from Two Trollius Species Using a Combination of Untargeted and Targeted Approaches

et al. 2020

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Various species of globeflowers, belonging to the genus Trollius, have been extensively used in traditional Chinese medicine due to their anti-inflammatory, antimicrobial, and antiviral properties, which are mainly attributed to their high polyphenol content. Differences in polyphenol composition, and abundances, will lead to varying treatment efficacies of globeflowers. Herein, we employ a combination of targeted and untargeted mass spectrometry (MS) approaches to characterize and quantify a comprehensive array of polyphenols, mainly including flavonoids and phenolic acids in two globeflower species commonly used in Chinese medicine, Trollius chinensis Bunge and Trollius ledebouri Reichb. In addition, free radical scavenging activity was investigated to evaluate the association between polyphenol composition and antioxidation capacity. Liquid chromatography (LC)-based separation and multiple-reaction-monitoring (MRM) transitions were optimized using a library of 78 polyphenol reference compounds to achieve absolute quantification on triple quadrupoles MS (QqQ). The analytical method was further expanded via high-resolution MS to provide relative quantitation of an additional 104 endogenous polyphenols in globeflowers not included in our reference library. Our results revealed stark differences in polyphenol content between T. chinensis and T. ledebouri, emphasizing the need for systematic characterization of polyphenol composition to ensure treatment efficacy and consistency in standardizing the use of globeflowers in Chinese medicine.

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In vitro anti-influenza virus effect of total flavonoid from Trollius ledebouri Reichb

Cited by 13 publications

References 19 publications

2D-SAR, Topomer CoMFA and molecular docking studies on avian influenza neuraminidase inhibitors

2D-SAR, Topomer CoMFA and molecular docking studies on avian influenza neuraminidase inhibitors

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Extensive Profiling of Polyphenols from Two Trollius Species Using a Combination of Untargeted and Targeted Approaches

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