In vitro anti‐tyrosinase activity of 5‐(hydroxymethyl)‐2‐furfural isolated from Dictyophora indusiata

Abstract

The inhibition of mushroom tyrosinase by methanolic extract of Dictyophora indusiata was evaluated and the bioactive component was characterized and identified as 5-(hydroxymethyl)-2-furfural (HMF) by chromatographic and spectroscopic means. Kinetic studies revealed it to be a noncompetitive inhibitor for the oxidation of L-DOPA. On the basis of these findings some related analogues were also tested for their anti-tyrosinase activity, in order to gain more insight into structure and activity relationship among these heterocyclic compounds.

5-Hydroxymethyl-2-Furfural (HMF) – Heat-Induced Formation, Occurrence in Food and Biotransformation - a Review

“…It was shown that HMF present in the extract was responsible for the inhibitory effect, and the kinetic studies revealed it to be a non--competitive inhibitor for the oxidation of L-DOPA [Sharma et al, 2004]. HMF was also identified as the active component in the hot water extracts of Lycium Chinese.…”

On the Basket Stinkhorn Mushroom Phallus merulinus (Phallaceae) in Mangalore, Karnataka, India

“…(Bakshi & Mandal 2006). Tyrosinase inhibitor (5-hydroxymethyl-2-furfural) could serve as skin depigmenting and lightening agent (Sharma et al 2004;Parvez et al 2006). Two glucans were isolated from P. (Hara et al 1982;Wang et al 2009) and fucomannogalactan (glycan) has been considered an immunomodulator (Wasser 2002;Zhang et al 2007).…”

Fragmentation Canals of Molecular Ions of GC-MS-Registered Components of Media of Shiitake Basidiomycete Submerged Cultivation in the Presence of Diacetophenonylselenide. Isomerization of Dihydrofurans and Their Cation Radicals

“…Логично, что «переброска сил» гриба с пути конверсии D-фруктозы в D-маннит способствует активизации альтернативного пути «фруктоза → 5-гидроксиметил-2-фуральдегид». Особенно если учесть, что последний ингибиру-ет фермент тирозиназу, ответственную за синтез грибного пигмента меланина, то есть служит ингибитором меланиногенеза [17].…”