In vitro anticancer activity of binuclear Ru(II) complexes with Schiff bases derived from 5-substituted salicylaldehyde and 2-aminopyridine with notably low IC₅₀ values

Redesigning Nature: Ruthenium Flavonoid Complexes with Antitumour, Antimicrobial and Cardioprotective Activities

“…Another relevant note is that the complexes were, in the large majority, inactive against Gram-negative bacteria [ 31 ]. This was expected as similar results had been previously observed with antimicrobial Ru(II) complexes comprising Schiff bases as ligands [ 44 , 45 ]. The higher resistance of Gram-negative bacteria is associated with the presence, in these microorganisms, of an additional lipopolysaccharide layer along the outer membrane, consequently thickening the cell wall and affecting the diffusion-controlled transport of these antimicrobial agents.…”

Dinuclear ruthenium(II) Schiff base complex: a first in vivo study in Swiss albino mice

“…To our knowledge, this is the fi rst in vivo study on dinuclear ruthenium(II) Schiff base complex. In previous in vitro studies, this complex showed signifi cant anticancer and antibacterial activity (2,8). Swiss albino mice of both sexes were treated with two doses of the compound to estimate the toxicity in otherwise healthy animals.…”

“…In vitro studies proved that this complex has a strong anticancer activity against different cancer cell lines and is even more potent than cisplatin. Also, it exhibits antibacterial activity against Gram positive bacteria (8). Nowadays ruthenium complexes, having good anticancer and antimicrobial activities, are reported daily, but all of them are not good candidates for in vivo investigations.…”

“…Nowadays ruthenium complexes, having good anticancer and antimicrobial activities, are reported daily, but all of them are not good candidates for in vivo investigations. At least three substantial reasons candidate Ru(II) Schiff base complex of N-(2-pyridyl)-5-chlorosalicylideneimine, over hundreds of other ruthenium(II) complexes, as promising agent for in vivo testing: (i) in vitro experiments showed that the complex binds DNA in a groove with moderate binding affi nity (binding constant 3.82 × 10 4 M -1 ), suggesting lower risk of genotoxicity; (ii) contrary to the classic chemotherapeutic drugs, very strong in vitro anticancer activity of this complex is not DNA dependent, implying that other biological pathways might be disrupted by the complex, which is especially important in fi ghting the metastases; (iii) strong antimicrobial activity of the complex, which is better or comparable to vancomycin (2,8).…”

Chalcone and Flavonol Copper(II) Complexes Containing Schiff Base Co-Ligand: Synthesis, Crystal Structures and Catecholase-like Activity

“…[13,14] One attractive use in the coordination chemistry has been to investigate the ability of these imines to act as phenoxo-bridging ligands in binuclear metal complexes. [15,16] Having azomethine group and other hard or soft donor atoms, Schiff bases are suitable to tune metal redox potential as the crucial parameter in many biochemical processes. A number of copper Schiff base complexes were reported to catalyze different chemical processes.…”