<i>In vitro</i>antileishmanial, antiplasmodial and cytotoxic activities of a new ventiloquinone and five known triterpenes from<i>Parinari excelsa</i>

Attioua, Barthélemy Koffi; Yeo, Dodehe; Lagnika, Latifou; Ramiarantsoa, Harisolo; Antheaume, Cyril; Weniger, Bernard; Kaiser, Marcel; Lobstein, Annelise; Vonthron-Sénécheau, Catherine

doi:10.3109/13880209.2011.633270

Cited by 13 publications

(6 citation statements)

References 29 publications

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“…In agreement with this, we found that trans-fagaramide was inactive against the chloroquine-sensitive strain 3D7 at the highest concentration tested (20 µg/mL). Chlorogenic acid [31][32][33] and neochlorogenic acid [32] showed no activity in our assays, which is consistent with the limited activity these compounds have against other strains. Due to insufficient amounts available, we were unable to test arnottianamide, burkinabin C, 6-hydroxy-dihydrochelerythine, dictamnine, and scoparone.…”

Section: Resultssupporting

confidence: 87%

Anti-plasmodial Effects of Zanthoxylum zanthoxyloides

et al. 2019

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Zanthoxylum zanthoxyloides, syn. Fagara zanthoxyloides, is a tree growing in West Africa and is used in traditional medicine against a variety of diseases, including malaria. In the work reported here, root bark and stem bark extracts of this tree, as well as compounds isolated from the extracts, have been investigated for activity in vitro against chloroquine-sensitive and chloroquine-resistant strains of Plasmodium falciparum. In addition, toxicity against nauplii of the brine shrimp Artemia salina has been studied. Dichloromethane extracts of the root bark and stem bark, and a methanol extract of the stem bark, showed anti-parasitic activity towards chloroquine-sensitive as well as chloroquine-resistant P. falciparum, with IC50 values between 1 and 10 µg/mL. Among the isolated compounds, bis-dihydrochelerythrinyl ether, buesgenine, chelerythrine, γ-fagarine, skimmianine, and pellitorine were the most active, with IC50 values of less than 5 µg/mL. The dichloromethane extracts were toxic to brine shrimp nauplii, with LC50 values of less than 1 µg/mL. Methanol extracts were much less toxic (LC50 between 50 and 100 µg/mL). Among the isolated substances, bis-dihydrochelethrinyl ether was the most toxic (LC50 ca. 2 µg/mL).

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Section: Resultssupporting

confidence: 87%

Anti-plasmodial Effects of Zanthoxylum zanthoxyloides

et al. 2019

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“…Several triterpenes have been reported to possess both in vitro and in vivo anti-plasmodial activity [18,19,20]. Of the three triterpenes that were isolated from M. caffra and M. obtusifolia (ursolic acid, taraxerol and sawamilletin), only ursolic acid showed any appreciable anti-plasmodial activity (IC 50 6.8 μg/mL) at the concentration tested.…”

Section: Resultsmentioning

confidence: 99%

Anti-Plasmodial Activity of Some Zulu Medicinal Plants and of Some Triterpenes Isolated from Them

et al. 2013

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Abstract:Mimusops caffra E. Mey. ex A.DC and Mimusops obtusifolia Lam (both members of the Sapotaceae family), and Hypoxis colchicifolia Bak (family Hypoxidaceae) are used by traditional healers in Zululand to manage malaria. Anti-plasmodial investigation of the crude extracts and some triterpenes isolated from the plants showed activity against a chloroquine sensitive (CQS) strain of Plasmodium falciparum (D10). Among the crude extracts the leaves of M. caffra exhibited the highest activity, with an IC 50 of 2.14 μg/mL. The pentacyclic tritepenoid ursolic acid (1), isolated from the leaves of M. caffra was the most active compound (IC 50 6.8 μg/mL) as compared to taraxerol (2) and sawamilletin (3) isolated from the stem bark of M. obtusifolia (IC 50 > 100). Chemical modification of the ursolic acid (1) to 3β-acetylursolic acid (4) greatly enhanced its anti-plasmodial activity. Compound 4 reduced parasitaemia against Plasmodium berghei by 94.01% in in vivo studies in mice. The cytotoxicity of 3β-acetylursolic acid (IC 50 ) to two human cell lines (HEK293 and HepG2) was 366.00 μg/mL and 566.09 μg/mL, respectively. The results validate the use of these plants in folk medicine.

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“…Many antimalarial investigations have also been done on plants used traditionally to treat infectious diseases with satisfactory results. This was demonstrated by results achieved with numerous studies on species from Benin Pharmacopoeia (Bero et al, 2013;Attioua et al, 2012;Djikpo-Tchibozo et al, 2011). Unfortunately, empirical and traditional knowledge are not registered and disappear over time.…”

Section: Introductionmentioning

confidence: 75%

Ethnobotanical survey of medicinal plants used in malaria management in South Benin

Lagnika¹,

Djehoue²,

Yédomonhan³

et al. 2016

J. Med. Plants Res.

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In Bénin, malaria is a major public health concern, especially for children under five years and pregnant women. Considering the inefficiency of the health centers in some regions, people use plants for their primary health care. This study aimed to identify and document the medicinal plants used in the treatment of malaria in four departments (Littoral, Ouémé, Plateau and Zou) of south Bénin. Data were recorded using interview and field observation. 42 informants including 15 traditional healers and 27 medicinal plants sellers with an average of fourteen years of experience were interviewed. Plants were identified by a botanist from the National Herbarium of Bénin. The study revealed that a total of 34 plants species belonging to 33 genera and 24 families were collected. The most frequently cited plant species was Chamaecrista rotundifolia, Senna siamea and Dialium guineense. Caesalpinioideae and Rubiaceae are the most families mentioned by the informants. The most common preparation method is decoction and the route of administration is oral. The results contributed to the conservation of empirical knowledge of medicinal plants used for the treatment of malaria and could help to identify new research topics in connection with the implementation of Traditional Medicines.

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In vitroantileishmanial, antiplasmodial and cytotoxic activities of a new ventiloquinone and five known triterpenes fromParinari excelsa

Cited by 13 publications

References 29 publications

Anti-plasmodial Effects of Zanthoxylum zanthoxyloides

Anti-plasmodial Effects of Zanthoxylum zanthoxyloides

Anti-Plasmodial Activity of Some Zulu Medicinal Plants and of Some Triterpenes Isolated from Them

Ethnobotanical survey of medicinal plants used in malaria management in South Benin

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