<i>In Vitro</i>Antioxidant and Anthelmintic Activity on<i>Luffa cylindrica</i>Leaf Extracts

Tripathi, Atul; Tandon, Manisha; Chandekar, Amol; Soni, Nilam J.; Upmanyu, Neeraj

doi:10.1080/10496475.2016.1224211

Cited by 6 publications

(8 citation statements)

References 12 publications

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“…The methanol and chloroform Luffa cylindrica leaves extract exhibited antioxidant property via enhanced scavenging of DPPH and superoxide radicals in a dose-dependent fashion [14]. Similarly, its methanol extract displayed free radical scavenging ability against hydrogen peroxide, hydroxyl and nitric oxide radicals.…”

Section: Pharmacological Activities 51 Antioxidant Activitymentioning

confidence: 93%

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A Review on the Ethnobotanical Uses, Phytochemistry and Pharmacological Effect of Luffa cylindrinca

Akinwumi¹,

Eleyowo²,

Oladipo³

2022

Natural Drugs From Plants

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Luffa cylindrica, popularly known as sponge gourd is a tropic and sub-tropical fibrous plant with fruits containing black seeds. The fruit is consumed by humans as a vegetable in many parts of Asia, while different parts of the plant are used for cosmetics and as medicine in many parts of the globe. The plant has been used in the treatment of many ailments including nose cancer, snake venom, wound healing, edema, enterobiasis, filaria, whooping cough, stomach upset, stomach pain and malaria. Many health-promoting compounds such as flavonoids (apigenin-7- glucuronide luteolin-7-O-β-D-glucuronide methyl ester, -O-feruloyl-β-D-glucose, luteolin-7-O-β-D-glucuronide methyl ester), phenolics acids (p-Coumaric, gallic, caffeic, chlorogenic), triterpenoids (oleanolic acid and echinocystic acid), saponins (Lucyoside A-M), tannins (catechin), ribosome-inactivating proteins (α- luffin), carotenoids (9 -cis neoxanthin, all-trans-lutein, all-trans-β-carotene), chlorophylls (chlorophyll a and b, pheophytin), cucurbitacin B and gypsogenin have been detected or isolated from different parts of the plants. Extracts of the plant and isolated compounds have wide spectrum pharmacological activities and have been shown to possess antiemetic, antidiabetic, antiviral, wound healing, anticancer, antipyretic, anti-inflammatory, antifungal, anti-bacteria, anthelmintic, hypoglycemic and antihyperglycemic, anti-inflammatory, antioxidant activity, and hepato-protective effects in animal models. However, further information is needed on its safety and mechanisms of action. The present article is an updated review of the ethnobotanical uses, pharmacological actions, phytochemistry, safety, and future application of Luffa cylindrica in translational medicine.

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Section: Pharmacological Activities 51 Antioxidant Activitymentioning

confidence: 93%

“…Both crude ethanol and methanol extracts of Luffa cylindrica leaves displayed anthelminthic activity against Pheretima posthuma [1,14]. In fact, the anthelminthic activity of the ethanol extract was comparable to the standard drug mebendazole [14].…”

Section: Anthelmintic Activitymentioning

confidence: 99%

A Review on the Ethnobotanical Uses, Phytochemistry and Pharmacological Effect of Luffa cylindrinca

Akinwumi¹,

Eleyowo²,

Oladipo³

2022

Natural Drugs From Plants

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“…Antioxidant activity, i.e. the percent inhibition of DPPH radical absorbance was calculated using the following equation [8].…”

Section: Methodsmentioning

confidence: 99%

The differences between the antioxidant activity of vitamin products

Rogóż

Karp²,

Kulig

et al. 2021

Medical Research Journal

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“…aegyptiaca contains alkaloids and saponins with known antimicrobial activities against E. coli, S. aureus, Salmonella typhi, and Bacillus subtilis [165]. The extract from Luffa aegyptiaca also possessed potential antioxidant and anthelmintic activity [84]. Caspase-3 may be activated by caspase-8 so as to trigger germ cell apoptosis.…”

Section: Luffa Aegyptiacamentioning

confidence: 99%

Review: Germinal Cell Apoptosis by Herbal Medicine

Situmorang

Ilyas

2018

Asian J Pharm Clin Res

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Apoptosis is a mechanism of cell death with a main role in cell recycling, which occurs in several organs: Testical, placenta, prostate, breast, ovarian, and cancer cells. Apoptotic signal pathway may be used to repair reproductive health disorders. Signal pathway of germ cell usually begins with extrinsic apoptotic pathway involving Fas/FasL molecule and mitochondrial pathway with Bcl-2 protein component. Apoptotic process in germ cell can also be triggered by exposing certain plant secondary metabolite to certain cells. Many plants have been reported successfully triggering apoptotic properties, i.e. (1) Areca catechu, (2) Carica papaya, (3) Camellia sinensis, (4) Curcuma domestica, (5) Costus speciosus, (6) Gossypium hirsutum, (7) Hibiscus spp., (8) Luffa aegyptiaca, (9) Momordica charantia, (10) Nicotiana tabacum, (11) Olea europaea, (12) Ocimum basilicum, and (13) Zingiber officinale. The metabolites may induce apoptosis through upregulating Fas/Fas-L and p53 expression, Bax/Bcl-2, along with caspase-3 activation. The mentioned plants then will induce apoptosis in germ cell and may become promising candidates to treat cancer as evidenced from extensive laboratory studies.

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In VitroAntioxidant and Anthelmintic Activity onLuffa cylindricaLeaf Extracts

Cited by 6 publications

References 12 publications

A Review on the Ethnobotanical Uses, Phytochemistry and Pharmacological Effect of Luffa cylindrinca

A Review on the Ethnobotanical Uses, Phytochemistry and Pharmacological Effect of Luffa cylindrinca

The differences between the antioxidant activity of vitamin products

Review: Germinal Cell Apoptosis by Herbal Medicine

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