<i>In vitro</i>antioxidant and antitumor activities of six selected plants used in the Traditional Arabic Palestinian herbal medicine

Husein, Ahmad; Ali‐Shtayeh, Mohammed S.; Jondi, Waheed; Zatar, Nidal A.; Abu‐Reidah, Ibrahim M.; Jamous, Rana M.

doi:10.3109/13880209.2014.886274

Cited by 51 publications

(56 citation statements)

References 33 publications

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“…Reactive oxygen species have a wide variety of pathological effects such as carcinogenesis, DNA damage and cell degeneration related to aging. It has been suggested in many in vitro and in vivo studies that dietary phenolic acids could protect and also inhibit the oxidative stress by scavenging free radicals and exposing antioxidant capacity [16][17][18][19] . The inhibition of carcinogenesis by phenolic compounds has revealed oncoprotective properties beneficial for the use of nutraceuticals in cancer therapy.…”

Section: Lonicera Caprifolium L (L Caprifolium)mentioning

confidence: 99%

Anticancer and antiangiogenic effects of methanol extracts of Lonicera caprifolium L. on C6 rat glioma cells

et al. 2016

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SUMMARYObjective: Gliomas are brain tumors with high morbidity and mortality. For the treatment of gliomas, it is important to develop new and powerful treatments that could complement existing clinical treatment. Lonicera caprifolium L. (L. caprifolium) has various uses in herbal traditional medicine. This study was conducted to determine the phenolic acid levels and DNA damage protection potential of L. caprifolium extract, and to explore the antitumor effect of the extract by investigating its toxicity on C6 rat glioma cell lines and normal L929 mouse fibroblast cell lines. We also aimed to investigate the antiangiogenic potential of the extract. Method: Phenolic acid content was determined by HPLC analysis. DNA damage protection potential was evaluated on pBR322 plasmid DNA. The effect of extracts on the proliferation of cancer cells was evaluated by XTT assay. Antiangiogenic effect was determined with Chorioallantoic membrane model. Results: The extract was found rich in vanillic acid (273.003 µg/g); while the amount of chlorogenic acid was almost at negligible level (0.028 µg/g). 0.005-0.05 mg / ml extract protected against the hazardous effects of UV and H2O2 in all DNA bands. The presence of the extract significantly reduced C6 cell proliferation compared to control (p<0.05). The extract had antiproliferative effect with a half maximum inhibition of concentration (IC50) value of 0.45 mg/ml. L. caprifolium extract in 10 -6 , 10 -5 and 10 -4 M concentrations caused antiangiogenic effect. Antiangiogenic scores of L. caprifolium were 0.6, 0.73 and 1.6, respectively. Conclusions: These results show that L. caprifolium has potential cytotoxic and antiangiogenic effect on C6 rat glioma cells and that the phenolic acid content of the plant may partially influence these activities. Keywords: Glioma, Lonicera caprifolium, angiogenesis, cytotoxic effect, phenolic acid 7 CMJCumhuriyet Medical Journal ÖZET Amaç: Gliomolar yüksek morbitite ve mortalite oranı olan beyin tümörleridir. Gliomaların tedavisi için, mevcut klinik tedaviye tamamlayıcı olabilecek yeni ve güçlü tedavi çözümleri geliştirmek önemlidir. Lonicera caprifolium L.'nin (L. caprifolium) bitkisel geleneksel tıpta çeşitli kullanımla-rı vardır. Bu çalışma, Lonicera caprifolium L. (Bahçe Hanımelisi) ekstraktının fenolik asit düzey-lerini ve DNA hasarı koruma potansiyelini belirlemek ve C6 sıçan glioma hücre hatları ve normal L929 fare fibroblast hücre hatları üzerindeki toksisitesinin inceleyerek Lonicera caprifolium ekstraktının anti-tümör etkisini araştırmak için gerçekleştirilmiştir. Bu çalışmada ayrıca ekstraktın antianjiyogenik potansiyelinin araştırılması amaçlanmıştır. Yöntem: Ekstraktların fenolik asit içeriği, HPLC analizi ile tespit edildi. DNA hasarı koruma potansiyeli pBR322 plazmid DNA üzerinde değerlendirildi. Ekstraktın kanser hücrelerinin proliferasyonu üzerindeki etkisi XTT testi ile değerlendirildi. Anti-anjiyogenik etki koryoallonterik membran modeli ile tespit edildi. Bulgular: Ekstrakt vanillik asitten (273,003 µg/g), zengin bulundu; kl...

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Section: Lonicera Caprifolium L (L Caprifolium)mentioning

confidence: 99%

Anticancer and antiangiogenic effects of methanol extracts of Lonicera caprifolium L. on C6 rat glioma cells

et al. 2016

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“…Aerial part of Urtica pilulifera extract shows highest cytotoxicity against breast infection, about 85% of the cells were found dead at the concentration of 500 µg/ml due to presence of phenolic compounds (phenolic compounds are known to inhibit mutagenesis in humans) 60 .…”

Section: Folk Language: Shisuunmentioning

confidence: 99%

“…Methanolic leaf extract of U. pilulifera had analyzed for antiarthritic activity as it inhabits the CFA induced paw swelling, skin lesions and articular deformity by suppressing inflammatory nuclear factor NF-κB in rats 52,53,60 .…”

Section: Antioxidantmentioning

confidence: 99%

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2018

IJPSR

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“…There are 3 studies on antioxidant activity of different extracts obtained from C.capitatus [4,6,7]. According to the work of Mokhtar and co-worker, ethyl acetate extract (IC 50 1.50 µg/mL) from C. capitatus showed stronger DPPH radical scavenging activity than diethyl ether extract (IC 50 1.92 µg/mL) [6].…”

Section: Introductionmentioning

confidence: 99%

“…is a member of the genus Coridothymus belongs to family Lamiaceae [3]. Aerial parts of Coridothymus capitatus are used againts cold, influenza, throat infection and in cosmetics, flavoring and pharmaceutical industry [4].…”

mentioning

confidence: 99%

Antioxidant and anti-inflammatory activities of Phlomis pungens and Coridothymus capitatus

Taşkın¹,

Çam²,

Bulut³

et al. 2018

mpj

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AbstrAct:The purpose of this study was to comparatively reveal for the first time the antioxidant, anti-inflammatory effects of Phlomis pungens and Coridothymus capitatus methanol extracts obtained by using maceration extraction method. According to the results of anti-inflammatory activity, P. pungens methanolic extract demonstrated a more prominent and intensive antiinflammatory effect with 24.7% of inhibitive capacity in the altered edema size after the first hour of carrageenan injection compared to C. capitatus methanolic extract. P. pungens methanolic extract inhibitory effect increased during three hours and reached maximum by 41.9%. According to the results obtained from antioxidant activity experiments, methanol extract of C. capitatus exhibited stronger free radical scavenging (DPPH), cupric reducing (CUPRAC), ferric reducing/antioxidant power (FRAP) and ABTS radical cation scavenging activity than P. pungens extract. In additon, C. capitatus extract had higher ABTS radical cation scavenging and ferric reducing/antioxidant power activity than ascorbic acid, BHT and BHA, respectively. Therefore, this extract can be used in both medicine and food industry as a natural antioxidant source.

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In vitroantioxidant and antitumor activities of six selected plants used in the Traditional Arabic Palestinian herbal medicine

Cited by 51 publications

References 33 publications

Anticancer and antiangiogenic effects of methanol extracts of Lonicera caprifolium L. on C6 rat glioma cells

Anticancer and antiangiogenic effects of methanol extracts of Lonicera caprifolium L. on C6 rat glioma cells

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Antioxidant and anti-inflammatory activities of Phlomis pungens and Coridothymus capitatus

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