<i>In vitro</i> antioxidant and wound healing properties of baru nut extract (<i>Dipteryx alata</i> Vog.) in pulmonary epithelial cells for therapeutic application in chronic pulmonary obstructive disease (COPD)

Coco, Julia Cedran; Ataide, Janaína Artem; Sake, Johannes A.; Tambourgi, Elias Basile; Ehrhardt, Carsten; Mazzola, Priscila Gava

doi:10.1080/14786419.2021.1984909

Cited by 4 publications

(2 citation statements)

References 32 publications

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“…Coco et al studied the ethanolic extract of Baru nuts, a native Brazilian species. The extract comprises phenolic compounds such as gallic acid, potentially exhibiting antioxidative and wound healing activity in human NCI-H441 and A549 lung epithelial cell lines [ 239 ].…”

Section: Natural Products Against Pulmonary Fibrosis With Specific Me...mentioning

confidence: 99%

Natural Product-Based Potential Therapeutic Interventions of Pulmonary Fibrosis

Hasan

Paul

et al. 2022

Molecules

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Pulmonary fibrosis (PF) is a disease-refractive lung condition with an increased rate of mortality. The potential factors causing PF include viral infections, radiation exposure, and toxic airborne chemicals. Idiopathic PF (IPF) is related to pneumonia affecting the elderly and is characterized by recurring scar formation in the lungs. An impaired wound healing process, defined by the dysregulated aggregation of extracellular matrix components, triggers fibrotic scar formation in the lungs. The potential pathogenesis includes oxidative stress, altered cell signaling, inflammation, etc. Nintedanib and pirfenidone have been approved with a conditional endorsement for the management of IPF. In addition, natural product-based treatment strategies have shown promising results in treating PF. In this study, we reviewed the recently published literature and discussed the potential uses of natural products, classified into three types—isolated active compounds, crude extracts of plants, and traditional medicine, consisting of mixtures of different plant products—in treating PF. These natural products are promising in the treatment of PF via inhibiting inflammation, oxidative stress, and endothelial mesenchymal transition, as well as affecting TGF-β-mediated cell signaling, etc. Based on the current review, we have revealed the signaling mechanisms of PF pathogenesis and the potential opportunities offered by natural product-based medicine in treating PF.

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Section: Natural Products Against Pulmonary Fibrosis With Specific Me...mentioning

confidence: 99%

Natural Product-Based Potential Therapeutic Interventions of Pulmonary Fibrosis

Hasan

Paul

et al. 2022

Molecules

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“…Several studies have shown antioxidant activity of the baru almond (and consequently of its oil) against oxidative stress, cardiovascular diseases risk, cancer, atherogenic indices, gastrointestinal diseases, abdominal adiposity, and wound healing. In addition, it helps to improve the lipid pro le in overweight individuals (Bailão et al, 2015;Bento et al, 2014;Coco et al, 2021;de Souza et al, 2018;Fetzer et al, 2018;Ragassi Fiorini et al, 2017). Furthermore, the increase in Cerrado deforestation and therefore the extinction of its species has been discussed.…”

Section: Introductionmentioning

confidence: 99%

Hydrocolloids and partially defatted cake on encapsulation of baru oil (Dipteryx alata Vogel): a study on emulsion, particle, and oxidative stability

Lima

Noguera

Granados

et al. 2022

Preprint

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The baru (Dipteryx alata Vogel) is a fruit of the Brazilian Cerrado, composed of a pleasant-tasting almond with a high oil content. The consumption of vegetable oils is suggested by the World Health Organization, but vegetable oils lack protection when extracted from their food matrix. Thus, the hydrocolloids Arabic gum (AG) and maltodextrin (MD) as well as the partially defatted cake (PDC), a co-product of the baru cold-pressed oil, were used to produce baru oil microparticles by spray drying. Fatty acid profile, emulsion stability, microparticle quality, and oxidative stability were evaluated. Baru oil is rich in omega-9 (47.3%). AG/MD (25% maltodextrin) showed better emulsion stability after 1h of preparation, higher zeta potential (-28.87 mV ± 0.026) and encapsulation efficiency (76.72% ± 0.002), and lower peroxide content after 4 weeks at 60°C (28.38 meq/kg). The addition of PDC improved the efficiency parameters in relation to the standard formulation (AG). The replacement of 25% of AG by MD improved the emulsion and microparticles' characteristics and better protected the baru oil against oxidation. Through a well-known technique, this study found technological use for a co-product of the extraction of baru oil and made good use of maltodextrin, a hydrocolloid with a lower relative cost.

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