<i>In Vitro</i> Antiviral Activity of <i>Mentha cordifolia</i> Plant Extract in HIV-1 Latently Infected Cells Using an Established Human Cell Line

Paz-Silava, Sheriah Laine M. de; Victoriano-Belvis, Ann Florence B; Gloriani, Nina G.; Hibi, Yurina; Asamitsu, Kaori; Okamoto, Takashi

doi:10.1089/aid.2021.0053

Cited by 5 publications

(2 citation statements)

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“…Blanco, namely globospiramine ( 1 ), deoxyvobtusine ( 2 ), and vobtusine lactone ( 3 ), by screening the inhibitory activity of viral transcription utilizing human cell lines latently infected with HIV, namely OM10.1 from a promyelocytic cell line [ 30 ] and J-Lat from a T-lymphocytic cell line [ 31 ]. The latent HIV provirus in these cell lines were reactivated by TNF-α, which can yield a 35-fold increase in the viral gene expression [ 32 ]. The suppressive activity of globospiramine ( 1 ), deoxyvobtusine ( 2 ), and vobtusine lactone ( 3 ) on HIV gene transcription in stimulated HIV latently infected cell lines were also investigated ( Figure 1 ) [ 33 ].…”

Section: Introductionmentioning

confidence: 99%

Voacanga globosa Spirobisindole Alkaloids Exert Antiviral Activity in HIV Latently Infected Cell Lines by Targeting the NF-κB Cascade: In Vitro and In Silico Investigations

et al. 2022

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Since the efficiency in the transcription of the HIV genome contributes to the success of viral replication and infectivity, we investigated the downregulating effects of the spirobisindole alkaloids globospiramine (1), deoxyvobtusine (2), and vobtusine lactone (3) from the endemic Philippine medicinal plant, Voacanga globosa, during HIV gene transcription. Alkaloids 1–3 were explored for their inhibitory activity on TNF-α-induced viral replication in two latently HIV-infected cell lines, OM10.1 and J-Lat. The induction of HIV replication from OM10.1 and J-Lat cells elicited by TNF-α was blocked by globospiramine (1) within noncytotoxic concentrations. Furthermore, globospiramine (1) was found to target the NF-ĸB activation cascade in a dose-dependent manner when the transcriptional step at which inhibitory activity is exerted was examined in TNF-α-induced 293 human cells using transient reporter (luciferase) gene expression systems (HIV LTR-luc, ĸB-luc, and mutant ĸB-luc). Interrogation through molecular docking against the NF-ĸB p50/p65 heterodimer and target sites of the subunits comprising the IKK complex revealed high binding affinities of globospiramine (1) against the S281 pocket of the p65 subunit (BE = −9.2 kcal/mol) and the IKK⍺ activation loop (BE = −9.1 kcal/mol). These findings suggest globospiramine (1) as a molecular inspiration to discover new alkaloid-based anti-HIV derivatives.

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Section: Introductionmentioning

confidence: 99%

Voacanga globosa Spirobisindole Alkaloids Exert Antiviral Activity in HIV Latently Infected Cell Lines by Targeting the NF-κB Cascade: In Vitro and In Silico Investigations

et al. 2022

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“…Cells treated with the extract inhibited viral replication in both cell culture supernatant and whole cell lysates. 34…”

Section: Antiviralmentioning

confidence: 99%

Pharmacologic Activities of Yerba Buena (Mentha x villosa Huds Fam. Lamiaceae): An Overview

2023

Acta Med Philipp

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Objectives. The aim of this study is to describe the pharmacologic activities of Yerba buena (Mentha x villosa Huds).Methods. Data were collected if available from online databases from 1950 to 2023 as well as the Philippine National Library, and unpublished clinical trials.Results. The initial search yielded thirty-seven studies from the different databases. After further screening, eighteen studies met the inclusion criteria. In vitro/in vivo studies of yerba buena showed antihypertensive, antibacterial, anthelmintic, antitumor, antiviral, and analgesic activities. Safety studies conducted showed that yerba buena possesses antimutagenic property. Clinical trial of yerba buena showed that oral administration of yerba buena and Paracetamol produced comparable analgesic efficacy. Conclusion.The medical benefits of yerba buena have been well-documented and thoroughly researched. Yerba buena was reported to have analgesic, antibacterial, anthelmintic, anticancer, antiviral, and antihypertensive properties. Among all the different activities, its analgesic activity was the only reported pharmacologic indication to have been clinically tested.

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Classification of Medicinal Plants Showing Antiviral Activity, Classified by Family and Viral Infection Types

Gurjar

Pal

2022

Reference Series in Phytochemistry

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In Vitro Antiviral Activity of Mentha cordifolia Plant Extract in HIV-1 Latently Infected Cells Using an Established Human Cell Line

Cited by 5 publications

References 54 publications

Voacanga globosa Spirobisindole Alkaloids Exert Antiviral Activity in HIV Latently Infected Cell Lines by Targeting the NF-κB Cascade: In Vitro and In Silico Investigations

Voacanga globosa Spirobisindole Alkaloids Exert Antiviral Activity in HIV Latently Infected Cell Lines by Targeting the NF-κB Cascade: In Vitro and In Silico Investigations

Pharmacologic Activities of Yerba Buena (Mentha x villosa Huds Fam. Lamiaceae): An Overview

Classification of Medicinal Plants Showing Antiviral Activity, Classified by Family and Viral Infection Types

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