In vitroantiviral activity of Brazilian plants (Maytenus ilicifoliaandAniba rosaeodora) against bovine herpesvirus type 5 and avian metapneumovirus

Kohn, Luciana Konecny; Queiroga, Carmen Lucia; Martini, Matheus Cavalheiro; Barata, Lauro Euclides Soares; Porto, Paulo Sérgio da Silva; Souza, Lara; Arns, Clarice Weis

doi:10.3109/13880209.2012.673627

Cited by 14 publications

(10 citation statements)

References 30 publications

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“…Among the species selected in this review, Anadenanthera colubrine (Vigerelli et al, 2014), Caesalpinia ferrea (Lopes et al, 2013; Marques et al, 2015), Lantana camara (Hasan, 2017), Maytenus ilicifolia (Khon et al, 2012), Schinus terebinthifolia (Nocchi et al, 2017), Solanum paniculatum (Valadares et al, 2009), Stryphnodendron adstringens (Felipe et al, 2006), Trichilia catigua (Espada et al, 2015) and Uncaria tomentosa (Caon et al, 2014; Reis et al, 2008) have already demonstrated action against different viruses which supports the antiviral potential of their constituents.…”

Section: Resultsmentioning

confidence: 99%

In silico approach of secondary metabolites from Brazilian herbal medicines to search for potential drugs against SARS‐CoV‐2

Amparo

Seibert

Almeida

et al. 2021

Phytotherapy Research

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The new severe acute respiratory syndrome coronavirus (SARS‐CoV‐2) recently emerged as a worrying pandemic, with many confirmed cases and deaths globally. Therefore, there is a clear need for identifying effective therapeutic options and a review of secondary metabolites related to Brazilian herbal medicines was performed as a strategy for the discovery of new antiviral agents. To confirm this potential, an in silico screening of the identified compounds identified was also evaluated. The review was performed by the PubMed database and the selected natural compounds were subjected to in silico analysis such as QSAR, molecular docking and ADMET. 497 secondary metabolites were identified from 23 species. The in silico assays indicated 19 potential anti‐SARS‐CoV‐2 compounds, being triterpenes and phenolic compounds. The indicated compounds showed a high affinity with proteins considered as the main molecular targets against SARS‐CoV‐2 and parameters indicated low toxicity. In addition to Brazilian medicinal plants, these compounds can be found in other species and they can be a base for the synthesis of other anti‐COVID‐19 drugs. Therefore, this review is important to conduct researches that address the emerging need for drugs in COVID‐19 treatment.

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Section: Resultsmentioning

confidence: 99%

In silico approach of secondary metabolites from Brazilian herbal medicines to search for potential drugs against SARS‐CoV‐2

Amparo

Seibert

Almeida

et al. 2021

Phytotherapy Research

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show abstract

“…The search for new therapeutic agents to control virus infection is one of the highest priorities in virological research [ 32 ], and an increasing number of recent studies have focused on utilizing natural sources to solve medical challenges [ 33 ].…”

Section: Discussionmentioning

confidence: 99%

Actinobacteria from Termite Mounds Show Antiviral Activity against Bovine Viral Diarrhea Virus, a Surrogate Model for Hepatitis C Virus

Padilla

Rodrigues

Bastos

et al. 2015

Evidence-Based Complementary and Alternative Medicine

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Extracts from termite-associated bacteria were evaluated for in vitro antiviral activity against bovine viral diarrhea virus (BVDV). Two bacterial strains were identified as active, with percentages of inhibition (IP) equal to 98%. Both strains were subjected to functional analysis via the addition of virus and extract at different time points in cell culture; the results showed that they were effective as posttreatments. Moreover, we performed MTT colorimetric assays to identify the CC50, IC50, and SI values of these strains, and strain CDPA27 was considered the most promising. In parallel, the isolates were identified as Streptomyces through 16S rRNA gene sequencing analysis. Specifically, CDPA27 was identified as S. chartreusis. The CDPA27 extract was fractionated on a C18-E SPE cartridge, and the fractions were reevaluated. A 100% methanol fraction was identified to contain the compound(s) responsible for antiviral activity, which had an SI of 262.41. GC-MS analysis showed that this activity was likely associated with the compound(s) that had a peak retention time of 5 min. Taken together, the results of the present study provide new information for antiviral research using natural sources, demonstrate the antiviral potential of Streptomyces chartreusis compounds isolated from termite mounds against BVDV, and lay the foundation for further studies on the treatment of HCV infection.

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“…Aniba is a genus of plants native to the Brazilian Amazon. It comprises 41 species, including Aniba rosaeodora, which have been reported to have sedative, antiviral, anticonvulsant, and antidepressant activities [94,95]. A. rosaeodora has been reported to be highly effective against head lice [32].…”

Section: Anibamentioning

confidence: 99%

Essential Oils as a Potential Treatment Option for Pediculosis

et al. 2020

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Pediculosis is a prevalent ectoparasite infestation caused by lice. The head louse (Pediculus humanus capitis) and body louse (Pediculus humanus humanus) are obligatory parasites whose only known hosts are humans. Pediculosis is probably the most common ectoparasitic infestation, affecting up to 80% of the population in several countries, and particularly prevalent in the infant population worldwide. Several treatment options, including shampoos and creams containing insecticides, have been introduced for the treatment of pediculosis. Recently, the use of synthetic chemicals to control human lice has raised concerns pertaining to human health and the environment. Therefore, increasing efforts have been undertaken to develop effective pediculicides with low environmental toxicity and minimal environmental residual activity. In this study, we focus on the essential oils derived from 22 plant genera, their constituents, and the major factors that play important roles in the effectiveness of these oils in the treatment of pediculosis. Furthermore, we discuss the advantages and limitations of the mentioned essential oils, and ultimately suggest those demonstrating the most effective in vitro pediculicidal activities. The genera such as Aloysia, Cinnamomum, Eucalyptus, Eugenia, Lavandula, Melaleuca, Mentha, Myrcianthes, Origanum, Pimpinella, and Thymus appear to be more efficient against lice. These genera are rich in anethole, 1,8-cineole, cinnamaldehyde, p-cymene, eugenol, linalool, limonene, pulegone, terpinen-4-ol, and thymol compounds.

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In vitroantiviral activity of Brazilian plants (Maytenus ilicifoliaandAniba rosaeodora) against bovine herpesvirus type 5 and avian metapneumovirus

Abstract: The biomonitored fractionation of the active extracts from M. ilicifolia and A. rosaeodora could be a potential tool for identifying their active compounds and determining the exact mechanism of action.

Cited by 14 publications

References 30 publications

In silico approach of secondary metabolites from Brazilian herbal medicines to search for potential drugs against SARS‐CoV‐2

In silico approach of secondary metabolites from Brazilian herbal medicines to search for potential drugs against SARS‐CoV‐2

Actinobacteria from Termite Mounds Show Antiviral Activity against Bovine Viral Diarrhea Virus, a Surrogate Model for Hepatitis C Virus

Essential Oils as a Potential Treatment Option for Pediculosis

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