<i>In Vitro</i> Antiviral Activity of Sakuranetin against Human Rhinovirus 3

Choi, Hwa-Jung

doi:10.24171/j.phrp.2017.8.6.09

Cited by 25 publications

(17 citation statements)

References 28 publications

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“…Furthermore, entry of rhinovirus was shown to be inhibited in silico by inhibition of the protein grid of virus [61]. Another flavonoid sakuranetin was also identified as a potent inhibitor of rhinovirus-3 by its antioxidant properties [62]. Several other flavonoids were reported to inhibit the activity of various picornaviruses [60,[63][64][65][66].…”

Section: Flavonoids Against Non-ev-a71 Picornavirusesmentioning

confidence: 99%

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Flavonoids as Antiviral Agents for Enterovirus A71 (EV-A71)

Lalani

Poh

2020

Viruses

161

101

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Flavonoids are natural biomolecules that are known to be effective antivirals. These biomolecules can act at different stages of viral infection, particularly at the molecular level to inhibit viral growth. Enterovirus A71 (EV-A71), a non-enveloped RNA virus, is one of the causative agents of hand, foot and mouth disease (HFMD), which is prevalent in Asia. Despite much effort, no clinically approved antiviral treatment is available for children suffering from HFMD. Flavonoids from plants serve as a vast reservoir of therapeutically active constituents that have been explored as potential antiviral candidates against RNA and DNA viruses. Here, we reviewed flavonoids as evidence-based natural sources of antivirals against non-picornaviruses and picornaviruses. The detailed molecular mechanisms involved in the inhibition of EV-A71 infections are discussed.

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Section: Flavonoids Against Non-ev-a71 Picornavirusesmentioning

confidence: 99%

“…In vitro Replication Antioxidant activity through inhibition of viral adsorption [62] Structures of flavonoids are provided in Supplementary Materials Table S1.…”

Section: Hrv-3mentioning

confidence: 99%

Flavonoids as Antiviral Agents for Enterovirus A71 (EV-A71)

Lalani

Poh

2020

Viruses

161

101

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“…In our experiments, sakuranetin was shown to exhibit anti‐influenza B/Lee/40 virus activity against influenza B/Lee/40 virus, reducing the formation of a visible CPE (Choi, ). Several previous reports have documented that flavonoids possess antiviral activities against human immunodeficiency virus, hepatitis B virus, and human rhinovirus 3 (Choi, ; Choi, Bae, Song, Baek, & Kwon, ; Choi, Song, et al, ). These properties are attributed to the antiviral activity of flavonoids.…”

Section: Resultsmentioning

confidence: 93%

“…A literature search on sakuranetin showed that sakuranetin inhibits chemically induced edema in mice and alleviates the allergen‐induced lung injury model through control of NF‐κB (Hernández, Recio, Máñez, Giner, & Ríos, ; Toledo et al, ). In our study, sakuranetin showed anti‐human rhinovirus 3 activity in vitro (Choi, ). However, to date, antiviral effects of sakuranetin against influenza B virus have not been reported.…”

Section: Introductionmentioning

confidence: 76%

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Suppression of influenza B virus replication by sakuranetin and mode of its action

Kwon

JeongHun

Yim

et al. 2018

Phytotherapy Research

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This study aimed to investigate in vitro the anti-influenza B/Lee/40 virus effect of sakuranetin and mode of its action. The sakuranetin exhibited potent antiviral activity against influenza B/Lee/40 virus, reducing the formation of a visible cytopathic effect, with a 50% inhibitory concentration (IC ) of 7.21 μg/ml and no cytotoxicity at a concentration of 100 μg/ml, and the derived therapeutic index (TI) was >13.87. Oseltamivir showed weak anti-influenza B/Lee/40 virus activity with IC of 80.74 μg/ml, 50% cytotoxicity concentration of >100 μg/ml, and TI of >1.24. Sakuranetin also showed effective inhibitory effects when added at the viral attachment, entry, and postentry steps. Moreover, sakuranetin effectively inactivated influenza B/Lee/40 virus infection in dose- and temperature-dependent manners. Sakuranetin indicated an inhibitory effect in viral RNA synthesis in the presence of 100 μg/ml of sakuranetin. Overall, this research revealed that sakuranetin could inhibit influenza B/Lee/40 virus replication and that sakuranetin may be involved in the virus attachment, entry, and postentry. Therefore, sakuranetin is a good candidate for a chemopreventive agent for influenza virus-related diseases.

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Standardized Eucalyptus maculata (Corymbia maculata) Resin Extract: Metabolomic Profiling, In Vitro and In Silico Study of Anti‐HSV Activity

Bassam,

Abdelwahab,

Teleb

et al. 2024

Chemistry & Biodiversity

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Recent episodes of viral pandemics have led to a quest for new drugs to act on emerging targets. Most challenging viruses are only mutants of already known viruses. Here comes the role of metabolomics in investigating natural secondary metabolites as sustainable antiviral drug candidates. Resins are natural plant products having the advantage of being concentrated and consisting of precious terpenoids, phenolics and flavonoids, known for their anti‐pathogen activity.  This study aimed at investigation of the major phytoconstituents in the Eucalyptus maculata (EM) resin using high resolution LC‐MS/MS and investigating its antiviral potential. In vitro screening of the standardized EM antiviral activity was performed. High resolution LC‐MS/MS analysis was done for the extract followed by investigation of the possible active metabolites through molecular docking techniques against two viral protein targets; herpes simplex virus glycoprotein D (HSV gD) and BTLA/HVEM complex. The evaluation in negative and positive modes identified 29 substances and revealed the prevalence of coumaryl and galloyl derivatives, in addition to kaempferol and aromadendrin derivatives. Antiviral in‐vitro screening led to the conclusion of the promising effect of the resin against HSV which was further confirmed through molecular docking. EM resin represents a future sustainable drug discovery.

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In Vitro Antiviral Activity of Sakuranetin against Human Rhinovirus 3

Cited by 25 publications

References 28 publications

Flavonoids as Antiviral Agents for Enterovirus A71 (EV-A71)

Flavonoids as Antiviral Agents for Enterovirus A71 (EV-A71)

Suppression of influenza B virus replication by sakuranetin and mode of its action

Standardized Eucalyptus maculata (Corymbia maculata) Resin Extract: Metabolomic Profiling, In Vitro and In Silico Study of Anti‐HSV Activity

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