<i>In vitro</i>
            assessment of dual (antiviral and antitumor) activity of a novel lectin produced by the newly cyanobacterium isolate,
            <i>Oscillatoria acuminate</i>
            MHM-632 MK014210.1

Saad, Mabroka H.; El‐Fakharany, Esmail M.; Salem, Marwa S.; Sidkey, Nagwa M.

doi:10.1080/07391102.2020.1848632

Cited by 16 publications

(10 citation statements)

References 92 publications

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“…Natural products derived from biological organisms, such as plants and prokaryotes, are also commercially available for their anti-tumor and anti-infective action (Saad et al 2022a ). One of the examples is dolastatin 10 (a secondary metabolite) derived from the cyanobacteria has been approved by the food and drug administration (FDA) for the cancer chemotherapeutic pipeline (Pereira et al 2019 ).…”

Section: Discussionmentioning

confidence: 99%

Cyanometabolites: molecules with immense antiviral potential

et al. 2023

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Cyanometabolites are active compounds derived from cyanobacteria that include small low molecular weight peptides, oligosaccharides, lectins, phenols, fatty acids, and alkaloids. Some of these compounds may pose a threat to human and environment. However, majority of them are known to have various health benefits with antiviral properties against pathogenic viruses including Human immunodeficiency virus (HIV), Ebola virus (EBOV), Herpes simplex virus (HSV), Influenza A virus (IAV) etc. Cyanometabolites classified as lectins include scytovirin (SVN), Oscillatoria agardhii agglutinin (OAAH), cyanovirin-N (CV-N), Microcystis viridis lectin (MVL), and microvirin (MVN) also possess a potent antiviral activity against viral diseases with unique properties to recognize different viral epitopes. Studies showed that a small linear peptide, microginin FR1, isolated from a water bloom of Microcystis species, inhibits angiotensin-converting enzyme (ACE), making it useful for the treatment of coronavirus disease 2019 (COVID-19). Our review provides an overview of the antiviral properties of cyanobacteria from the late 90s till now and emphasizes the significance of their metabolites in combating viral diseases, particularly severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which has received limited attention in previous publications. The enormous medicinal potential of cyanobacteria is also emphasized in this review, which justifies their use as a dietary supplement to fend off pandemics in future. Graphical abstract

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Section: Discussionmentioning

confidence: 99%

Cyanometabolites: molecules with immense antiviral potential

et al. 2023

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“…Among these, lectins are ubiquitous proteins, whose carbohydrate domains have been shown to interact with the surface of cells and viruses. For example, a lectin recently isolated from the cyanobacterium Oscillatoria acuminate was found to be inhibitory against herpes simplex virus type‐1 at doses at low as 20 ng ml −1 with highest inhibition at a dose of 2 mg ml −1 (Saad et al ., 2020 ). Because pre‐treating the cells prior to viral infection was not found to be protective, it is most likely that this lectin interacts and interferes with viral receptors.…”

Section: Antibacterial Activitymentioning

confidence: 99%

Health benefits of microalgae and their microbiomes

Krohn

Menanteau–Ledouble

Hageskal

et al. 2022

Microbial Biotechnology

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Microalgae comprise a phylogenetically very diverse group of photosynthetic unicellular pro-and eukaryotic organisms growing in marine and other aquatic environments. While they are well explored for the generation of biofuels, their potential as a source of antimicrobial and prebiotic substances have recently received increasing interest. Within this framework, microalgae may offer solutions to the societal challenge we face, concerning the lack of antibiotics treating the growing level of antimicrobial resistant bacteria and fungi in clinical settings. While the vast majority of microalgae and their associated microbiota remain unstudied, they may be a fascinating and rewarding source for novel and more sustainable antimicrobials and alternative molecules and compounds. In this review, we present an overview of the current knowledge on health benefits of microalgae and their associated microbiota. Finally, we describe remaining issues and limitation, and suggest several promising research potentials that should be given attention.

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“…A novel cyanobacterial protein, MVL, inhibited the HIV-1 Envelope-mediated cell fusion with an IC50 value of 30 nM (Bewley et al, 2004). Oscillatoria agardhii agglutinin (OAA), a lectin compound isolated from Oscillatoria agardhii, inhibited human immunodeficiency virus replication in MT-4 cells with an EC50 of 44.5 nM (Saad et al, 2022). Proteins griffithsin (GRFT) and scytovirin (SVN) isolated from cyanobacteria Griffithsia sp.…”

Section: Proteinsmentioning

confidence: 99%

Revisiting the role of cyanobacteria-derived metabolites as antimicrobial agent: A 21st century perspective

et al. 2022

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Cyanobacterial species are ancient photodiazotrophs prevalent in freshwater bodies and a natural reservoir of many metabolites (low to high molecular weight) such as non-ribosomal peptides, polyketides, ribosomal peptides, alkaloids, cyanotoxins, and isoprenoids with a well-established bioactivity potential. These metabolites enable cyanobacterial survival in extreme environments such as high salinity, heavy metals, cold, UV-B, etc. Recently, these metabolites are gaining the attention of researchers across the globe because of their tremendous applications as antimicrobial agents. Many reports claim the antimicrobial nature of these metabolites; unfortunately, the mode of action of such metabolites is not well understood and/or known limited. Henceforth, this review focuses on the properties and potential application, also critically highlighting the possible mechanism of action of these metabolites to offer further translational research. The review also aims to provide a comprehensive insight into current gaps in research on cyanobacterial biology as antimicrobials and hopes to shed light on the importance of continuing research on cyanobacteria metabolites in the search for novel antimicrobials.

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In vitro assessment of dual (antiviral and antitumor) activity of a novel lectin produced by the newly cyanobacterium isolate, Oscillatoria acuminate MHM-632 MK014210.1

Cited by 16 publications

References 92 publications

Cyanometabolites: molecules with immense antiviral potential

Cyanometabolites: molecules with immense antiviral potential

Health benefits of microalgae and their microbiomes

Revisiting the role of cyanobacteria-derived metabolites as antimicrobial agent: A 21st century perspective

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