In-vitro bioassay of electrophoretically deposited hydroxyapatite–zirconia nanocomposite coating on Ti–6Al–7Nb implant

Abstract

Hydroxyapatite-zirconia (HA-ZrO 2 ) nanocomposite coatings were prepared on Ti-6Al-7Nb implant by electrophoretic deposition at constant voltage of 50 V. The influence of zirconia content on the phase transition, morphological evolution, wettability and in vitro cytocompatibility, together with the bioactivity of the nanostructured coatings was examined. From the X-ray diffractometer patterns, a tangible increase and decrease in the peak intensity and width of the characteristic peaks were observed after subsequent sintering at 1000°C for 1 h under a constant flow of argon gas. The sintered HA and HA-ZrO 2 composite coatings showed higher hydrophilicity than the bare substrate. From the in vitro bioassays, surface treatment of Ti67 implant by HA-ZrO 2 nanocomposite coating increased the cell response as well as the apatite formability, in simulated body fluid within 5 days of incubation.

Hydroxyapatite Consolidated by Zirconia: Applications for Dental Implant

“…Sandhyarani et al [83] fabricated nanostructured ZrO 2 /HAp coating on zirconium and studied in-vitro performance of manufactured composites. HAp particles were dragged into the evacuation channels, during the film growth step, then by electrophoretic deposition process entrapped into the oxide film.…”

Development of New Mg- or Sr-Containing Bioactive Interfaces to Stimulate Osseointegration of Metallic Implants

“…In other words, a successful replacement operation implies the emergence of a strong bond between the implantable entity and host tissue, followed by an active bioconnection at the surface level. The identified solution consists in covering the orthopaedic implants with ceramics [14], glasses [15] or vitroceramics [16,17] in order to functionally modify their external side and provide bioactivity and increased biocompatibility, as well as a specific framework for performant integration and osseointegration [18,19]. Among the multitude of artificial materials that enhance the efficiency of metallic implants (demineralized bone matrix, coralline hydroxyapatite, calcium phosphate-based ceramics, etc.…”

Severe sink-in occurrence in thermally sprayed hydroxyapatite coating

“…For instance, they might be sorted in accordance with the development method, where all kinds of coatings can be grouped into two big classes including conversion ones, which are generated by reaction products of the base material and deposited ones [13]. Further, the deposited approach might be categorized in accordance with the deposition methods, such as plasma spraying, high-velocity oxy-fuel spraying, RF magnetron sputtering, pulsed laser deposition (laser ablation), dip coating, ion beam assisted deposition, electrostatic spray deposition, spin coating, sol-gel technique, electrophoretic deposition, electrochemical (cathodic) deposition, biomimetic process, hydrothermal deposi-S. Saber-Samandari et al / Processing and Application of Ceramics 12 [2] (2018) 189-197 tion, thermal substrate deposition, hot isostatic pressing, micro-arc oxidation, and dynamic mixing method [14][15][16][17][18]. Among them, thermally sprayed HA coatings are widely used for various biomedical applications because of its ability to form thin HA coatings on a variety of orthopaedic prosthesis and dental implants [19][20][21][22][23].…”