<i>In vitro</i>biological activity of secondary metabolites from<i>Seseli rigidum</i>Waldst. et Kit. (Apiaceae)

Jakovljević, Dragana; Vasić, Sava M.; Stanković, Milan; Čomić, Ljiljana R.; Topuzović, Marina

doi:10.1556/018.66.2015.4.4

Cited by 8 publications

(4 citation statements)

References 24 publications

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“…Et Kit. (aqueous, acetone, ethyl acetate, methanol and petroleum ether) were evaluated, whereby the acetone extract was found to have the highest TPC and TFC (102.13 mg GAE/g and 291.58 mg RE/g, respectively) [28]. The different levels of bioactive contents could be explained by geographical and climatic factors (altitude, rainfall, etc.)…”

Section: Resultsmentioning

confidence: 99%

Comprehensive Biological and Chemical Evaluation of Two Seseli Species (S. gummiferum and S. transcaucasicum)

et al. 2021

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Seseli L. is one of the largest genera of the Apiaceae family widely known for their traditional uses as herbal remedies. In the present study, the methanolic and water extracts of two Seseli species, S. gummiferum and S. transcaucasicum were evaluated for their bioactive contents and biological activities. The total phenolic and flavonoid contents in the extracts ranged from 19.09 to 24.33 mg GAE/g and from 0.45 to10.09 mg RE/g, respectively. Moreover, while narcissin was detected as the most abundant component in the methanolic extract of S. transcaucasicum (261.40 µg/g), chlorogenic acid was identified as the major component in all the other extracts, although a high amount was also present in the methanolic S. transcaucasicum extract (107.48–243.12 µg/g). The total antioxidant capacity was also determined by the phosphomolybdenum assay (0.66–1.18 mM TE/g). Other antioxidant assays such as the radical scavenging assays (DPPH: 5.51–11.45 mg TE/g; ABTS: 43.46–51.91 mg TE/g), reducing assays (CUPRAC: 41.67–53.20 mg TE/g; FRAP: 31.26–34.14 mg TE/g), as well as the metal chelating activity assay (14.38–38.57 mg EDTAE/g) were conducted. All the extracts showed inhibitory potential against the enzyme’s amylase (0.12–0.78 mM ACAE/g), acetyl- and butyryl-cholinesterase (0.15–9.71 mg GALAE/g), while only the methanolic extracts acted as inhibitors of tyrosinase (107.15 and 109.37 mg KAE/g) and only the water extract of S. gummiferum displayed anti-glucosidase activity (0.13 mM ACAE/g). Interestingly, the methanolic extracts of both Seseli species showed lower cytotoxicity towards HaCaT cells (IC50: >500 µg/mL), compared to the water extracts (IC50: 267.8 and 321.41 µg/mL). Besides, only the methanolic extracts showed a slight wound healing effect (28.21 and 31.23%). All extracts showed antibacterial action against Staphylococcus lugdunensis (minimum inhibitory and bactericidal concentrations: 0.025–2 mg/mL). S. gummiferum methanolic extract, which exhibited the highest antibacterial potency was found to inhibit adhesion and invasion of S. lugdunensis to HaCaT cells as well. Taken together, this study demonstrated the two Seseli species to harbour interesting bioactive components, in particular polyphenolics and to exhibit several biological properties that could be further investigated for their potential exploitation as healing agents as supported by various traditional medicinal uses.

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Section: Resultsmentioning

confidence: 99%

Comprehensive Biological and Chemical Evaluation of Two Seseli Species (S. gummiferum and S. transcaucasicum)

et al. 2021

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“…The total flavonoids content of FS was measured according to Jakovljević et al (2015) with some modifications. Dried FS powder (0.2 g) was treated with a 20-fold volume of an ethanol solution (70%).…”

Section: Determination Of Total Flavonoids Rutin and Quercetinmentioning

confidence: 99%

Steaming and vacuum drying preserve active components, sensory and antioxidant properties of Flos Sophorae

et al. 2023

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Flos Sophorae (FS) is medicinal and edible, while fresh FS is highly perishable. Thus, this study investigated the effects of different drying methods (hot air drying, HAD; vacuum drying, VD; freeze drying, FD) after steaming on the bioactive components and sensory quality of FS. The results indicated steaming for 1 min maximally retained the contents of total flavonoids, rutin, and quercetin in thermal drying (HAD and VD), meanwhile, the freeze-dried FS without steaming also had higher total flavonoids and rutin contents. Moreover, FD samples had the highest protein content and organoleptic properties, with closer color parameters to fresh FS, followed by the VD group. Considering comprehensively all data with processing cost, the sample of VD after steaming for 1 min was chosen to measure the antioxidant activity, which showed that FS extract was superior to Vc in ABTS• and •OH scavenging rates, and its DPPH• scavenging rate was stronger than Vc in the low concentration. These results demonstrated that vacuum drying after steaming for 1 min was suitable postharvest processing for fresh FS, which was beneficial to maintaining higher flavonoids, rutin, and sensory characteristics of FS, and its flavonoid extract had better antioxidant activity than Vc.

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“…In the other study, the antioxidant activity of Seseli rigidum was also evaluated on five extracts in different polarity (water, methanol, acetone, ethyl acetate, and petroleum ether). The antioxidant effect of the aerial parts of the species was determined in vitro using DPPH reagent, and the greatest antioxidant activity was expressed in water extract (46.15 µg/mL) (Jakovljević et al, 2015). Also, some of the compounds isolated from the methanolic extracts (80%) of Seseli diffusum have been found to have a strong antioxidant effect (Abbaskhan et al, 2012).…”

Section: U N C O R R E C T E D P R O O Fmentioning

confidence: 99%

EVALUATION of ANTIOXIDANT POTENCY on SESELI L. SPECIES (APIACEAE)

Önder¹,

Çınar²,

Sarıaltın³

et al. 2019

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In vitrobiological activity of secondary metabolites fromSeseli rigidumWaldst. et Kit. (Apiaceae)

Cited by 8 publications

References 24 publications

Comprehensive Biological and Chemical Evaluation of Two Seseli Species (S. gummiferum and S. transcaucasicum)

Comprehensive Biological and Chemical Evaluation of Two Seseli Species (S. gummiferum and S. transcaucasicum)

Steaming and vacuum drying preserve active components, sensory and antioxidant properties of Flos Sophorae

EVALUATION of ANTIOXIDANT POTENCY on SESELI L. SPECIES (APIACEAE)

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