2015
DOI: 10.4015/s1016237215500222
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IN VITROCHARACTERIZATION OF TRAMADOL-HCL-LOADED POLYOXALATE MICROSPHERES DESIGNED FOR CONTROLLED DRUG RELEASE

Abstract: This study evaluates the properties of Tramadol- HCl -loaded polyoxalate (TH-loaded POX) microspheres prepared by oil-in-oil (O1/O2) emulsion solvent evaporation method, specifically designed for sustained drug release. Morphology and physicochemical characteristics of the as-fabricated were studied by scanning electron microscopy (SEM), X-ray diffraction (XRD), differential scanning calorimeter (DSC) and Fourier transform infrared (FTIR) spectroscopy, while the encapsulation efficiency and release profile of … Show more

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