In vitro Cytotoxic Activity of Sesamin Isolated from Vismia baccifera var. dealbata Triana &amp; Planch (Guttiferae) Collected from Venezuela

Buitrago

Natural Product Communications

et al. 2011

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The essential oil from the fruits of Vismia baccifera Triana & Planch. (Gutttiferae), collected in June 2009, was analyzed by GC/MS. A yield of 0.6% oil was obtained by hydrodistillation. Twenty-seven components were identified by comparison of their mass spectra with those in the Wiley GC-MS Library data base. The major components were trans-cadin-1,4-diene (36.6%), cis-cadin-1,4-diene (18.8%) and β-caryophyllene (11.9%). The essential oil showed a broad spectrum of antibacterial activity against the important human pathogenic Grampositive and Gram-negative bacteria Staphylococcus aureus (ATCC 25923), Enterococcus faecalis (ATCC 29212), Escherichia coli (ATCC 25992), Pseudomonas aeruginosa (ATCC 27853) and Klebsiella pneumoniae (ATCC 23357) with MIC values ranging from 9 to 37 µg/mL.

mentioning

confidence: 70%

Essential Oil Composition and Antibacteral Activity of Vismia Baccifera Fruits Collected from Mérida, Venezuela

Buitrago

Natural Product Communications

et al. 2011

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“…Previous investigations have reported 161 compounds isolated from different Vismia species where anthrones, xanthones, lignans, benzophenones and anthraquinones are the most frequent types of components observed (Hussain et al, 2012;Vizcaya, Morales, Rojas, & Nuñez, 2012). Regarding biological properties, several investigations have been carried out either in extracts or pure isolated compounds, reveling antimicrobial (Buitrago et al, 2015;Vizcaya et al, 2014;Silvestre et al, 2012), antioxidant (Tala et al, 2011;Silvestre et al, 2012;Buitrago, Rojas, Rojas, & Peñaloza, 2016), anti-VIH (Gómez-Cansino et al, 2015, anti-inflammatory, antinociceptive (Ferreira et al, 2015), parasiticidal, cardiotonic (Gomes et al, 2009) and cytotoxic (Salas, Rojas, Morales, Ramos-Nino, & Colmenares, 2008;Rojas, Buitrago, Arvelo, Sojo, & Suarez, 2017), among other, biological activities.…”

mentioning

confidence: 99%

Essential oil composition and cytotoxic activity in two species of the plant genus Vismia (Hypericaceae) from the Venezuelan Andes

Rojas-Vera¹,

Díaz²,

Arvelo³

et al. 2020

RBT

Abstract. Introduction: The Vismia genus belongs to the Hypericaceae family and comprises around 57 species of which 17 have been located in Venezuela. Previous investigations have been carried out in extracts as well as pure isolated compounds, revealing antimicrobial, antioxidant and anti-HIV, among other, biological activities. Objective: This investigation aims to determine the cytotoxic activity of essential oils from leaves of Vismia baccifera Triana & Planch (VBJ and VBV) and Vismia macrophylla Kunth (VM) collected in three different locations of the Venezuelan Andean region. Methods: Essential oils obtained by hydrodistillation were analyzed using gas chromatography-mass spectrometry (GC-MS) and their cytotoxic activity was analyzed following the MTT (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide) assay. Human tumor cell lines from SKBr3, MCF-7 and PANC-1, two breast carcinomas and one pancreatic adenocarcinoma of ductal type, were tested with the oil samples and human dermis fibroblasts were used as non-tumor cells. Results: β-caryophyllene and trans-caryophyllene were present as major components in VBJ and VBV, respectively, while γ-bisabolene was the main component in the VM sample. Anticancer activity was observed on V. baccifera essential oil against SKBr3, MCF-7 and PANC-1. The selectivity index showed that VBV is highly selective against the SKBr3 cell line and has no activity against non-tumor cells. Conclusions: These results are considered a contribution to natural products research and may provide supportive data for future studies on cancer.

“…dealbata and compounds isolated from it (sesamin, friedelin and vismiaquinone) displayed significant activity against S. aureus, S. faecalis and P. aeruginosa [5]. In vitro cytotoxic activity of Sesamin, isolated from the same species has also been evaluated, showing a statistically significant activity on the lung cancer cell line NCI-H292 with an IC 50 of 1 g/mL compared to non-cytotoxic activity against a normal lung ephitelial cell line [6]. The only report to date on the essential oil composition of a Vismia species is that for V. baccifera var.…”

mentioning

confidence: 99%

Essential Oil Composition of Vismia macrophylla Leaves (Guttiferae)

Buitrago

Natural Product Communications

et al. 2011

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The essential oil from Vismia macrophylla Kunth (Guttiferae) leaves, extracted by hydrodistillation, was analyzed by GC/MS. The oil obtained (yield 0.11%) contained twenty-eight compounds, which were identified from their retention indices and by comparison of their mass spectra with those in the Wiley GC-MS Library data base. The major components were β-caryophyllene (20.1%), germacrene D (11.6%) and β-elemene (7.0%).