In vitro dissolution method fitted to in vivo absorption profile of rivaroxaban immediate-release tablets applying in silico data

Abstract

The in vitro dissolution method designed promoted a more convenient dissolution profile of RIV tablets, whereas it suggests a better relationship with in vivo performance.

Rivaroxaban eutectics with improved solubility, dissolution rates, bioavailability and stability

“…The rivaroxaban marketed tablet is an immediate-release tablet; therefore, a dissolution study for 1 h was performed in distilled water as a dissolution medium. 43,44 RXB and selected eutectic powders equivalent to 15 mg of the drug were used for the dissolution study. RXB showed a cumulative release of 16%; also, the dissolution study for the physical mixtures showed no significant change in the dissolution properties compared to pure rivaroxaban.…”