In vitro effects of some anabolic compounds on erythrocyte carbonic anhydrase I and II

In vitroinhibition effect and structure–activity relationships of some saccharin derivatives on erythrocyte carbonic anhydrase I and II

“…In summary, enzyme inhibition is the most important issue for drug design and biochemical applications [15][16][17][18][19][20][21][22][23][24][25][26][27] . Therefore, our results suggested that saccharin derivatives are likely to be adopted as candidates to treat glaucoma and may be taken for further evaluation in in vivo studies.…”

In vitro effects of estrogen and progesterone containing drugs on human erythrocyte carbonic anhydrase I and II isozymes in women smokers and nonsmokers

“…Dexketoprofen trometamol has been shown to be the strongest inhibitor against the erythrocyte human CA I and human CA II, whereas diclofenac sodium increased enzyme activities. 23 Gencer et al 24 investigated the effects of the some anabolic compounds on CA I and CA II enzymes, and the report that 17-b estradiol is the strongest inhibitor against CA I and diethylstilbestrol is the strongest inhibitor against CA II enzyme activity. In our study, dienogest, a synthetic new progestin, was found to be the strongest inhibitor against both CA I and CA II enzymes.…”

In vitro inhibition effect of some coumarin compounds on purified human serum paraoxonase 1 (PON1)

“…Pharmacological studies, including enzyme-drug interaction analyses, are becoming increasingly vital important [25][26][27][28][29] . In a study, it was shown that a lactam derivative namely 2-hydroxyquinoline inhibited PON1 effectively 30 .…”