2016
DOI: 10.1128/aac.00757-16
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In Vitro Emergence of High Persistence upon Periodic Aminoglycoside Challenge in the ESKAPE Pathogens

Abstract: bHealth care-associated infections present a major threat to modern medical care. Six worrisome nosocomial pathogens-Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter spp.-are collectively referred to as the "ESKAPE bugs." They are notorious for extensive multidrug resistance, yet persistence, or the phenotypic tolerance displayed by a variant subpopulation, remains underappreciated in these pathogens. Importantly, persistence … Show more

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Cited by 83 publications
(65 citation statements)
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“…Second, we confirmed the longstanding prediction of a direct correlation between the evolved persister level and the frequency of antibiotic treatments in E. coli [24]. Daily aminoglycoside exposure selects for extreme persistence levels up to almost 100%, not only in E. coli [24] but also in all ESKAPE pathogens and any species we tested so far [25]. Moreover, all evolutionary changes take place in a short timeframe, less than 100 generations, and are caused by individual single nucleotide polymorphisms or small insertions or deletions.…”
supporting
confidence: 67%
“…Second, we confirmed the longstanding prediction of a direct correlation between the evolved persister level and the frequency of antibiotic treatments in E. coli [24]. Daily aminoglycoside exposure selects for extreme persistence levels up to almost 100%, not only in E. coli [24] but also in all ESKAPE pathogens and any species we tested so far [25]. Moreover, all evolutionary changes take place in a short timeframe, less than 100 generations, and are caused by individual single nucleotide polymorphisms or small insertions or deletions.…”
supporting
confidence: 67%
“…berculous mycobacterial pulmonary infections (8,9). Recurrent infections that are attributable to bacterial persisters occur in a wide variety of biofilm-related infections (e.g., lung, urinary tract, device associated, and wound infections) caused by an array of bacterial pathogens (10)(11)(12).…”
mentioning
confidence: 99%
“…) and the development of persister strains on antibiotic therapy (Michiels et al . ). The current therapeutic options for multidrug‐resistant pathogens has been severely limited by rapid increase in resistance and decrease in the development of new classes of antibiotics (Gelbrand et al .…”
Section: Introductionmentioning
confidence: 97%
“…AMR causes a problem for providing effectual health care services and controlling the incidence of diseases in the community. Some of the salient features that negatively impact patients with infections by drug-resistant pathogens are: a rise in incidence of human infections by these organisms, a significant increase in AMR among these strains (Boucher et al 2009), the infections they cause have worse clinical outcomes than infections caused by the susceptible strains (Pogue et al 2015) and the development of persister strains on antibiotic therapy (Michiels et al 2016). The current therapeutic options for multidrug-resistant pathogens has been severely limited by rapid increase in resistance and decrease in the development of new classes of antibiotics (Gelbrand et al 2015).…”
Section: Introductionmentioning
confidence: 99%