<i>In vitro</i>evaluation and pharmacokinetics in dogs of guar gum and Eudragit FS30D-coated colon-targeted pellets of indomethacin

Ji, Chongmin; Xu, Huinan; Wu, Wei

doi:10.1080/10611860601143727

Cited by 57 publications

(22 citation statements)

References 38 publications

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“…The supernatant was analyzed by HPLC for indomethacin content. This method has been validated for linearity, accuracy, precision, extraction recovery and limit of quantification (Ji et al, 2007).…”

Section: Determination Of Indomethacin In Tablets Release Media and mentioning

confidence: 99%

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Anin situcrosslinked compression coat comprised of pectin and calcium chloride for colon-specific delivery of indomethacin

Wei

Lü

et al. 2014

Drug Delivery

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(2015) An insitu crosslinked compression coat comprised of pectin and calcium chloride for colon-specific delivery of indomethacin, Drug Delivery, 22:3, 298-305, DOI: 10.3109/10717544.2013 AbstractThe use of pectin for colon-specific drug delivery has been extensively investigated; however, when used alone, pectin is often compromised due to its high solubility. This study explored the feasibility of using an in situ compression-coated crosslinking system, composed of pectin and calcium chloride, for colon-specific drug delivery. A pectin/calcium chloride (P/Ca) coating was compressed onto a core tablet. The colon specificity of the compression-coated tablet was verified by dissolution, pharmacokinetics and scintigraphy with 99m Tc labeling. The in situ pectin and calcium chloride gel slowed the release of indomethacin. The lag time varied between 3 h and 7 h depending on the amount of calcium chloride and the coating weight. Pectinase triggered the release of indomethacin from the compression-coated tablet, which was then accelerated by the calcium chloride in the coating layer. The compression-coated tablet had a prolonged t max and apparent t 1/2 , as well as a decreased C max and AUC 0-t , compared with the core tablet counterpart. Evaluation with g-scintigraphy verified colonspecific delivery of the compression-coated tablet. In conclusion, the P/Ca in situ crosslinking system worked well for colon-specific drug delivery.

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Section: Determination Of Indomethacin In Tablets Release Media and mentioning

confidence: 99%

“…The detection wavelength was set at 320 nm. The above HPLC method was also adapted for the determination of indomethacin in dog plasma (Ji et al, 2007). Samples were prepared by liquid-liquid extraction.…”

Section: Determination Of Indomethacin In Tablets Release Media and mentioning

confidence: 99%

Anin situcrosslinked compression coat comprised of pectin and calcium chloride for colon-specific delivery of indomethacin

Wei

Lü

et al. 2014

Drug Delivery

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“…Fluidized bed coating is mainly used to develop modified release (13), pulsatile release (14) or to increase drug bioavailability (15). There are only a few studies reported where fluidized bed coating was implemented for tastemasking purposes (9,16,17).…”

Section: Introductionmentioning

confidence: 99%

Development and Evaluation of Cetirizine HCl Taste-Masked Oral Disintegrating Tablets

2010

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Abstract. The purpose of the current study was to mask the taste of cetirizine HCl and to incorporate the granules produced in oral disintegrating tablets (ODT). The bitter, active substance was coated by fluidized bed coating using Eudragit® RL30-D at levels between 15% and 40% w/w. The ODTs were developed by varying the ratio of superdisintegrants such as sodium croscarmellose, crospovidone grades and low substituted hydroxypropyl cellulose (L-HPC). A direct compression process was used to compress the ODTs under various compaction forces to optimize tablet robustness. The properties of the compressed tablets including porosity, hardness, friability and dissolution profiles were further investigated. The in vitro and in vivo evaluation of the tablet disintegration times showed almost identical rapid disintegration below 10 s at the optimal levels of each superdisintegrant. Finally, the taste and sensory evaluation in human volunteers demonstrated excellence in masking the bitter active and tablet palatability.

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“…The most commonly used dissolution testing methods for these delivery systems (which have few limitations 11 ) involve the addition of enzymes, [11][12][13][14][15][16][17] rat cecal contents, [18][19][20][21] and human fecal slurries. [22][23][24][25][26][27][28][29][30][31] Under colonic conditions, enzymes are continuously replenished by the microbiota that secretes these enzymes.…”

Section: Introductionmentioning

confidence: 99%

A novel dissolution media for testing drug release from a nanostructured polysaccharide-based colon specific drug delivery system: an approach to alternative colon media

Kotla¹,

Singh²,

Maddiboyina³

et al. 2016

IJN

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The aim of this study was to develop a novel microbially triggered and animal-sparing dissolution method for testing of nanorough polysaccharide-based micron granules for colonic drug delivery. In this method, probiotic cultures of bacteria present in the colonic region were prepared and added to the dissolution media and compared with the performance of conventional dissolution methodologies (such as media with rat cecal and human fecal media). In this study, the predominant species (such as Bacteroides, Bifidobacterium, Lactobacillus species, Eubacterium and Streptococcus ) were cultured in 12% w/v skimmed milk powder and 5% w/v grade “A” honey. Approximately 10 10 –10 11 colony forming units m/L of probiotic culture was added to the dissolution media to test the drug release of polysaccharide-based formulations. A USP dissolution apparatus I/II using a gradient pH dissolution method was used to evaluate drug release from formulations meant for colonic drug delivery. Drug release of guar gum/Eudragit FS30D coated 5-fluorouracil granules was assessed under gastric and small intestine conditions within a simulated colonic environment involving fermentation testing with the probiotic culture. The results with the probiotic system were comparable to those obtained from the rat cecal and human fecal-based fermentation model, thereby suggesting that a probiotic dissolution method can be successfully applied for drug release testing of any polysaccharide-based oral formulation meant for colonic delivery. As such, this study significantly adds to the nanostructured biomaterials’ community by elucidating an easier assay for colonic drug delivery.

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In vitroevaluation and pharmacokinetics in dogs of guar gum and Eudragit FS30D-coated colon-targeted pellets of indomethacin

Cited by 57 publications

References 38 publications

Anin situcrosslinked compression coat comprised of pectin and calcium chloride for colon-specific delivery of indomethacin

Anin situcrosslinked compression coat comprised of pectin and calcium chloride for colon-specific delivery of indomethacin

Development and Evaluation of Cetirizine HCl Taste-Masked Oral Disintegrating Tablets

A novel dissolution media for testing drug release from a nanostructured polysaccharide-based colon specific drug delivery system: an approach to alternative colon media

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