<i>In Vitro</i> Evaluation of Bortezomib Encapsulated in Cationic and C6-Ceramide Liposomes

Joshi, MedhaD.; Park, Gabriel; Pichlik, Jennifer; Patel, Krisha; Patel, Roshni

doi:10.1166/jpsp.2017.1081

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Cited by 3 publications

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“…A few recent publications describe liposomal formulations of bortezomib by using various encapsulation methods. In a recent report, an attempt was made to load bortezomib into the liposome bilayer (Joshi et al, 2017). The loading efficiency, however, was substantially low for these liposomes ranging from 17 to 36%.…”

Section: Resultsmentioning

confidence: 99%

Development and characterization of liposomal formulation of bortezomib

Deshantri

Metselaar

Zagkou

et al. 2019

International Journal of Pharmaceutics: X

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Section: Resultsmentioning

confidence: 99%

Development and characterization of liposomal formulation of bortezomib

Deshantri

Metselaar

Zagkou

et al. 2019

International Journal of Pharmaceutics: X

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Bortezomib-loaded lipidic-nano drug delivery systems; formulation, therapeutic efficacy, and pharmacokinetics

Mahmoudian

Valizadeh

Löbenberg

et al. 2021

Journal of Microencapsulation

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Nanotechnology-based Drug Delivery Systems as Potential for Skin Application: A Review

Baveloni

Riccio

Filippo

et al. 2021

CMC

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: Administration of substances through the skin represents a promising alternative, in relation to others drug administration routes, due to its large body surface area, in order to offer ideal and multiple sites for drug administration. In addition, the administration of drugs through the skin avoids first-pass metabolism, allowing an increase in the bioavailability of drugs, as well as reducing their side effects. However, the stratum corneum (SC) comprises the main barrier of protection against external agents, mainly due to its structure, composition and physicochemical properties, becoming the main limitation for the administration of substances through the skin. In view of the above, pharmaceutical technology has allowed the development of multiple drug delivery systems (DDS), which include liquid crystals (LC), cubosomes, liposomes, polymeric nanoparticles (PNP), nanoemulsions (NE), as well as cyclodextrins (CD) and dendrimers (DND). It appears that the DDS circumvents the problems of drug absorption through the SC layer of the skin, ensuring the release of the drug, as well as optimizing the therapeutic effect local. This review aims to highlight the DDS that include LC, cubosomes, lipid systems, PNP, as well as CD and DND, to optimize topical skin therapies.

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In Vitro Evaluation of Bortezomib Encapsulated in Cationic and C6-Ceramide Liposomes

Cited by 3 publications

References 0 publications

Development and characterization of liposomal formulation of bortezomib

Development and characterization of liposomal formulation of bortezomib

Bortezomib-loaded lipidic-nano drug delivery systems; formulation, therapeutic efficacy, and pharmacokinetics

Nanotechnology-based Drug Delivery Systems as Potential for Skin Application: A Review

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