<i>In vitro</i> evaluation of efficacy of dihydroartemisinin‐loaded methoxy poly(ethylene glycol)/poly(<scp>l</scp>‐lactic acid) amphiphilic block copolymeric micelles

Lu, Wen-fen; Chen, Shui-fang; Wen, Zujia; Li, Qiang

doi:10.1002/app.38518

Cited by 11 publications

(9 citation statements)

References 47 publications

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“…However, DHA-CM had almost no effect on L02 cell lines, indicating that the nanomicelles had toxic effects on specific cancer cells. 98 Berberine (Alkaloid) Berberine is the major active extract constituent of the rhizome of Chinese coptis (Chinese Goldthread Rhizome). 99 Berberine has been found to induce apoptosis or inhibit cell growth in a number of cancer cells (human tongue squamous cells, nerve tissue and liver).…”

Section: Encapsulation Of Selected Phytochemicalsmentioning

confidence: 99%

Nanopharmaceutics: Phytochemical-Based Controlled or Sustained Drug-Delivery Systems for Cancer Treatment

Jeetah¹,

Bhaw‐Luximon²,

Jhurry³

2014

j biomed nanotechnol

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This review is an attempt to assess the different classes of phytochemicals and some of their members which have been encapsulated into nanocarrier systems for their chemotherapeutic or chemopreventive properties. Given the broad spectrum of nanomedicines currently in clinical trial and clinical use from polymer-protein conjugates, through nanocrystals, nanogels, dendrimers to ethosomes, the focus of this review will be on block copolymer nanomicelles, nanoparticles, polymer-drug conjugates, liposomes and solid lipid nanocarriers (SLNs). The twenty phytochemicals investigated for encapsulation and targeted delivery were selected from a variety of classes intended to encompass the largest possible chemical compositions, namely flavonoids, aromatic acids, xanthones, terpenes, quinones, lignans and alkaloids. To the best of our knowledge, reviews on the nanoencapsulation of these phytochemicals and their delivery are not available. In this review, the issues associated with the limited use of each phytochemical in cancer therapy in humans are reviewed and the advantages of entrapment into nanocarriers are assessed in terms of drug loading efficiency, size of nanocarriers, drug release profiles and in vitro and/or in vivo testing specific to cancer research, e.g., cytotoxicity assay, cell inhibition/viability, scavenging of reactive oxygen species and biodistribution studies (elimination half-life and mean residence time).

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Section: Encapsulation Of Selected Phytochemicalsmentioning

confidence: 99%

Nanopharmaceutics: Phytochemical-Based Controlled or Sustained Drug-Delivery Systems for Cancer Treatment

Jeetah¹,

Bhaw‐Luximon²,

Jhurry³

2014

j biomed nanotechnol

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“…Lu et al encapsulated dihydroartemisinin into methoxypoly(ethylene glycol)/poly( l -lactic acid) with anticancer effects. The micelles were worm-like with particle size of 130 nm [ 49 ]. In vitro drug release from the micelles was dependent on the stability of micelles, pH, rate of biodegradation of the micelles and rate of diffusion of the incorporated drug from the micelles.…”

Section: Delivery Systems Loaded With Artemisinin and Its Derivatimentioning

confidence: 99%

“…Their effects on normal cell lines was minimal and potent on cancer cell lines. This indicated that micelles can reduce the toxic side effects associated the incorporated drug [ 49 ].…”

Section: Delivery Systems Loaded With Artemisinin and Its Derivatimentioning

confidence: 99%

“…Incorporation of artemisinin and its derivatives to polymeric micelles resulted in improved drug stability, enhanced cellular uptake and controlled release of the drugs resulting in increased bioavailability [ 46 , 47 , 48 , 49 ]. In vitro evaluation of the micelles loaded with artemisinin and its derivatives inhibited the growth of cancer cell lines when compared to free artemisinin and its derivatives [ 47 , 48 , 49 ]. The release of the drugs was pH dependent [ 46 , 47 , 49 ].…”

Section: Delivery Systems Loaded With Artemisinin and Its Derivatimentioning

confidence: 99%

“…In vitro evaluation of the micelles loaded with artemisinin and its derivatives inhibited the growth of cancer cell lines when compared to free artemisinin and its derivatives [ 47 , 48 , 49 ]. The release of the drugs was pH dependent [ 46 , 47 , 49 ]. However, the application of micelles for artemisinin is limited by poor drug incorporation and burst effects [ 49 ].…”

Section: Delivery Systems Loaded With Artemisinin and Its Derivatimentioning

confidence: 99%

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Design of Drug Delivery Systems Containing Artemisinin and Its Derivatives

Aderibigbe

2017

Molecules

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Artemisinin and its derivatives have been reported to be experimentally effective for the treatment of highly aggressive cancers without developing drug resistance, they are useful for the treatment of malaria, other protozoal infections and they exhibit antiviral activity. However, they are limited pharmacologically by their poor bioavailability, short half-life in vivo, poor water solubility and long term usage results in toxicity. They are also expensive for the treatment of malaria when compared to other antimalarials. In order to enhance their therapeutic efficacy, they are incorporated onto different drug delivery systems, thus yielding improved biological outcomes. This review article is focused on the currently synthesized derivatives of artemisinin and different delivery systems used for the incorporation of artemisinin and its derivatives.

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Artemisinin and its derivatives in cancer therapy: status of progress, mechanism of action, and future perspectives

Bhaw‐Luximon

Jhurry

2017

Cancer Chemother Pharmacol

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Since the late 1990s, there has been rapid multiplication of data on the anti-cancer properties of artemisinins. This article reviews the status of progress of artemisinin and its derivatives as anti-cancer agents in clinical trials, case reports, and in vitro/in vivo studies. Particular attention is laid on the combinations of artemisinins and synthetic chemodrugs to enhance the latter's efficacy. An attempt is here made to rationalize the synergistic effects of a few common anti-cancer drugs of the anthracycline, taxane, anti-metabolite, and platinum-based drug families. The various pathways that mediate the action of artemisinins as reported over the past decade are here summarized highlighting also the biomarkers that could be used to better predict the efficacy of the sesquiterpenoids. Their main action seems to be directed toward stalling tumor cell proliferation through cell cycle arrest mediated by reactive oxygen species (ROS). The emergence of artemisinins' nano-based formulations in combination with chemodrugs to enhance drug bioavailability and targeting as well as immunotherapy is also reviewed. The enhanced efficacy of artemisinin dimers compared to the parent molecules and standard chemotherapy is analyzed. While these therapies hold promises, it may be premature to conclude on their efficacy in the absence of clinical studies.

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In vitro evaluation of efficacy of dihydroartemisinin‐loaded methoxy poly(ethylene glycol)/poly(l‐lactic acid) amphiphilic block copolymeric micelles

Cited by 11 publications

References 47 publications

Nanopharmaceutics: Phytochemical-Based Controlled or Sustained Drug-Delivery Systems for Cancer Treatment

Nanopharmaceutics: Phytochemical-Based Controlled or Sustained Drug-Delivery Systems for Cancer Treatment

Design of Drug Delivery Systems Containing Artemisinin and Its Derivatives

Artemisinin and its derivatives in cancer therapy: status of progress, mechanism of action, and future perspectives

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