In vitro fertilisation in Sweden: obstetric characteristics, maternal morbidity and mortality

Abstract

Objective To investigate obstetric characteristics, maternal morbidity and mortality among Swedish women giving birth after in vitro fertilisation (IVF) treatment. Design Register study. Setting Nationwide study in Sweden. Sample All women known to have had IVF in Sweden 1982–2001. Methods Using Swedish health registers, women who had given birth after IVF were identified from all Swedish IVF clinics and compared with all women who gave birth. Analysis was performed with the Mantel–Haenszel technique. Main outcome measures Diagnoses during pregnancy, at delivery and at re‐admission within 60 days after delivery and risk of cancer. Results IVF women had an increased risk of bleeding in early pregnancy [odds ratio (OR) = 4.59, 95% confidence interval (95% CI) 4.08–5.15] and of ovarian torsion during pregnancy (OR = 10.6, 5.69–10.7). They were also more likely to encounter pre‐eclampsia (OR = 1.63, 1.53–1.74), placental abruption (2.17, 1.74–2.72), placenta praevia (3.65, 3.15–4.23), bleeding in association with vaginal delivery (1.40, 1.38–1.50) and premature rupture of membranes (PROM) (2.54, 2.34–2.76). Interventions including caesarean sections (1.38, 1.32–1.43) and induction of labour (1.37, 1.29–1.46) in singleton pregnancies was more frequent. The type of IVF method had little effect on these results, but there was a tendency for women who had received intra‐cytoplasmatic sperm injection (ICSI) to have slightly fewer complications than women having standard IVF. There was a significant decrease in cancer risk after IVF (0.79, 0.69–0.91) but a suggested increase in the risk of ovarian cancer both before (2.70, 1.49–4.91) and after (2.08, 1.15–3.76) IVF. No change in mortality was observed. Conclusions Women treated with IVF had an increased obstetric morbidity. This seems to contribute little to the well‐known increased risk of preterm delivery.

In vitro fertilization and breast cancer: is there cause for concern?

“…In contrast, two other studies found a possible increase in the risk of breast cancer in those undergoing IVF, with those aged >40 years (15) and >30 years (16) at increased risk. In yet another contrast, three other studies (17)(18)(19) found a slight decrease in the risk of breast cancer in women who gave birth after IVF, compared with either the general population of women who gave birth or with women who gave birth but did not have IVF treatment.…”

Ivf versus spontan singleton pregnancies fetal and maternal outcomes in a tertiary care hospital

“…Kallen et al [22] and Romundstad et al [23] found increased placenta previa rates in IVF cycles than naturally conceived pregnancies, 4 fold and 6 fold higher respectively. Allen et al [24] also emphasized increased maternal complications in IVF pregnancies, 2 fold higher in gestational hypertension, gestational diabetes and caesarean deliveries than naturally conceived singleton pregnancies.…”

Reflections on evolution

“…The incidence of placenta praevia is also significantly increased in both IVF and ICSI assisted pregnancies, as embryos are more likely to implant in the lower segment owing to placement position on embryo transfer (Hayashi & Nakai, Satoh & Matsuda 2012;Kallen, Finnstrom, Nygren, Olausson & Wennerholm, 2005;Nygren, Finnstrom, Kallen & Olausson, 2007;Poikkeus, Gissler, Unkila-Kallio, Hyden-Granskog, & Tiitinen, 2007;Sazonova, Ka¨llen, Thurin-Kjellberg, Wennerholm & Bergh, 2011).…”