In vitroFLASH irradiation of A549 lung cancer cells and IMR90 healthy human fibroblasts in the synchrocyclotron room of a clinical proton therapy system
Adrián Zazpe,
Inés del Monte-García,
Nerea Palao
et al.
Abstract:Purpose: This study aims to investigate the FLASH irradiation effect on lung tumor (A549) and healthy fibroblast (IMR90) cell lines using an irradiation station installed at the synchrocyclotron room of a clinical proton facility. Methods and Materials: An irradiation system composed of a lead scatterer and 3D-printed positioning system was designed and fabricated to operate within the beamline gap of the IBA Proteus One proton therapy facility. A dosimetric analysis of the produced irradiation field was carri… Show more
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