<i>In vitro</i>gastrointestinal digestion and simulated colonic fermentation of pistachio nuts determine the bioaccessibility and biosynthesis of chronobiotics

Dufoo‐Hurtado, Elisa; Olvera-Bautista, Rocio; Wall‐Medrano, Abraham; Loarca‐Piña, Guadalupe

doi:10.1039/d0fo02708a

Cited by 6 publications

(2 citation statements)

References 71 publications

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“…While there may be some discrepancy in melatonin in plant foods due to growing and harvesting conditions, there remains some debate about whether pistachios supply this amount of melatonin. Despite these inconsistencies, pistachios still feature prominently on the list of melatonin-containing foods and may have chronobiotic potential [ 234 ].…”

Section: Therapeutic Considerationsmentioning

confidence: 99%

Is Melatonin the “Next Vitamin D”?: A Review of Emerging Science, Clinical Uses, Safety, and Dietary Supplements

Minich

Henning²,

Darley

et al. 2022

Nutrients

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Melatonin has become a popular dietary supplement, most known as a chronobiotic, and for establishing healthy sleep. Research over the last decade into cancer, Alzheimer’s disease, multiple sclerosis, fertility, PCOS, and many other conditions, combined with the COVID-19 pandemic, has led to greater awareness of melatonin because of its ability to act as a potent antioxidant, immune-active agent, and mitochondrial regulator. There are distinct similarities between melatonin and vitamin D in the depth and breadth of their impact on health. Both act as hormones, affect multiple systems through their immune-modulating, anti-inflammatory functions, are found in the skin, and are responsive to sunlight and darkness. In fact, there may be similarities between the widespread concern about vitamin D deficiency as a “sunlight deficiency” and reduced melatonin secretion as a result of “darkness deficiency” from overexposure to artificial blue light. The trend toward greater use of melatonin supplements has resulted in concern about its safety, especially higher doses, long-term use, and application in certain populations (e.g., children). This review aims to evaluate the recent data on melatonin’s mechanisms, its clinical uses beyond sleep, safety concerns, and a thorough summary of therapeutic considerations concerning dietary supplementation, including the different formats available (animal, synthetic, and phytomelatonin), dosing, timing, contraindications, and nutrient combinations.

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Section: Therapeutic Considerationsmentioning

confidence: 99%

Is Melatonin the “Next Vitamin D”?: A Review of Emerging Science, Clinical Uses, Safety, and Dietary Supplements

Minich

Henning²,

Darley

et al. 2022

Nutrients

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“…FAD produced the highest total SCFAs, followed by FAD‐E at 24 h incubation (110.6 and 106.3 mM/L, respectively). Since those values are similar to or even higher than those from common beans (Campos‐Vega et al., 2009), spent coffee grounds (light and dark roasted) (López‐Barrera et al., 2016), and pistachio nuts (Dufoo‐Hurtado et al., 2021), it is suggested that the insoluble fiber of FAD and FAD‐E CPH (their predominant dietary fiber component) is highly fermentable. Recently, processing has been suggested to boost insoluble dietary fiber fermentability.…”

Section: Resultsmentioning

confidence: 94%

Effect of drying method on the production of in vitro short‐chain fatty acids and histone deacetylase mediation of cocoa pod husk

Nieto-Figueroa

Gaytán–Martínez

Loarca-Piña

et al. 2022

Journal of Food Science

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We evaluated the effect of cocoa pod husk (CPH) processing (microwave [MW], forced-air drying [FAD], and FAD plus extrusion [FAD-E]), and in vitro gastrointestinal digestion on the in vitro human colonic fermentation metabolism, in vitro bioactivity on human HT-29 colon cancer cell, and the in silico mechanism of selected compounds. CPH as a substrate for human colonic microbiota significantly decrease local pH (MW −0.7, FAD −0.2, and FAD-E −0.3, 24 h) and modifies their metabolic activity (short-chain fatty acids[SCFAs] production). FAD-E generated the highest butyric (7.6 mM/L, 4 h) and FAD the highest acetic and propionic acid levels (71.4 and 36.7 mM/L, 24 h). The in vitro colonic fermented FAD-E sample (FE/FAD-E) caused HT-29 colorectal cancer cells death by inducing damage on membrane integrity and inhibiting (up to 92%) histone-deacetylase (HDAC) activity. In silico results showed that chlorogenic acid, (−)-epicatechin, and (+)-catechin, followed by butyric and propionic acids, are highly involved in the HDAC6 inhibitory activity. The results highlight the potential human health postbiotic benefits of CPH consumption, mediated by colonic microbiota-derived metabolites. K E Y W O R D Scocoa pod husk, in vitro colonic fermentation, in vitro gastrointestinal digestion, histone deacetylase, human colon cancer cells, postbiotic Practical Application: The enormous amount of CPH (10 tons/1 ton of dry beans) generated by the cocoa industry can be used as a removable source of bioactive compounds with physicochemical functionality and health bioactivity. However, their potential applications and health benefits are insufficiently explored. CPH represents a serious disposal problem; practical and innovative ideas to use this highly available and affordable material are urgent. Research exploring their potential applications can increase the sustainability of the cocoa agro-industry. This paper highlights the value addition that can be achieved with this valuable industrial co-product, generating new functional products and ingredients.

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Molecular Mechanisms of Chronobiotics as Functional Foods

Dufoo‐Hurtado

Wall‐Medrano

Campos-Vega

2022

Molecular Mechanisms of Functional Food

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In vitrogastrointestinal digestion and simulated colonic fermentation of pistachio nuts determine the bioaccessibility and biosynthesis of chronobiotics

Abstract: Chronodisruption leads to obesity and other metabolic disorders that food-derived chronobiotics such as phytomelatonin (PMT), phenolic compounds (PCs) and dietary fiber rich pistachios may help to alleviate. We evaluated the...

Cited by 6 publications

References 71 publications

Is Melatonin the “Next Vitamin D”?: A Review of Emerging Science, Clinical Uses, Safety, and Dietary Supplements

Is Melatonin the “Next Vitamin D”?: A Review of Emerging Science, Clinical Uses, Safety, and Dietary Supplements

Effect of drying method on the production of in vitro short‐chain fatty acids and histone deacetylase mediation of cocoa pod husk

Molecular Mechanisms of Chronobiotics as Functional Foods

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