<i>In vitro</i>nematocidal effects of medicinal plants from São Paulo state, Brazil

Slomp, Liege; Pereira, Paulo Sérgio; França, Suzelei de Castro; Zingaretti, Sônia Marli; Beleboni, Renê Oliveira

doi:10.1080/13880200802434658

Cited by 18 publications

(13 citation statements)

References 19 publications

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“…Considering the traditional use of medicinal plants in developing countries, in vitro and in vivo studies have been carried out to investigate plant species effectiveness as alternative anthelmintics to control gastrointestinal infections in small ruminants or even as nematocidals in general (Batista et al, 1999;Slomp et al, 2009). Annona muricata L. (Annonaceae), popularly known in Brazil as graviola, is a medium-sized fruit tree commonly found in the tropics.…”

Section: Introductionmentioning

confidence: 99%

In vitro anthelmintic activity of aqueous leaf extract of Annona muricata L. (Annonaceae) against Haemonchus contortus from sheep

Ferreira

Castro

Chagas

et al. 2013

Experimental Parasitology

103

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Despite the overall progress of sheep farming in Brazil, infections with the gastrointestinal parasite Haemonchus contortus represent one the most important problems in sheep production, aggravated by the increasing resistance of nematodes to traditional anthelmintic drugs caused by inadequate sheep flock management by breeders. Ethnopharmacological data indicate Annona muricata as a promising alternative for the control of gastrointestinal nematodes because of its general anthelmintic properties. The aim of this work was to evaluate the in vitro anthelmintic effects of A. muricata aqueous leaf extract against eggs, infective larvae and adult forms of parasitic nematode H. contortus. At higher doses, A. muricata extract showed 84.91% and 89.08% of efficacy in egg hatch test (EHT) and larval motility test (LMT), respectively. In the adult worm motility test, worms were completely immobilized within the first 6-8h of nematode exposition to different dilutions of extract. Phytochemical analysis indicated the presence of phenolic compounds in A. muricata aqueous leaf extract that may be responsible for the anthelmintic effects observed. Moreover those results validate the traditional use of A. muricata as a natural anthelmintic and then the pharmacological potential of its compounds for future in vivo investigations.

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Section: Introductionmentioning

confidence: 99%

In vitro anthelmintic activity of aqueous leaf extract of Annona muricata L. (Annonaceae) against Haemonchus contortus from sheep

Ferreira

Castro

Chagas

et al. 2013

Experimental Parasitology

103

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“…A redução populacional de P. brachyurus nesse experimento pode estar relacionada à decomposição das folhas de T. diversifolia que liberou substância nematicida e, consequentemente, causando toxicidade aos nematoides. Tal fato pode ser sustentado pelos resultados encontrados por Slomp et al (26), que verificaram que flavanóides provenientes de extratos de folhas de T. diversifolia apresentaram ação nematicida em P. zeaee P. jaehni. Estes autores relatam que os flavonóides são sintetizados pelas plantas em resposta às infecções microbianas, justificando sua ação antimicrobiana frente a vários microrganismos.…”

Section: Resultsunclassified

Folhas de girassol mexicano como alternativa no manejo de Pratylenchus brachyurus em quiabeiro

et al. 2018

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RESUMO Objetivou-se verificar o potencial de folhas de girassol mexicano (Tithonia diversifolia) como alternativa de manejo ao nematoide Pratylenchus brachyurus em quiabeiro. Foram conduzidos dois ensaios em casa de vegetação, em delineamento inteiramente casualizado, com sete repetições, sendo cada parcela composta por um vaso contendo uma planta. Utilizou-se o quiabeiro como planta indicadora e o sorgo como testemunha suscetível. Os tratamentos foram cinco níveis de fitomassa verde e seca (0, 5, 10, 15 e 20 g kg-1 de solo) de T. diversifolia, incorporada ou na forma de cobertura do solo, para avaliar o efeito sobre a população de P. brachyurus. A incorporação de folhas frescas de T. diversifolia no solo, como adubo verde, reduziu a população de P. brachyurus 60 dias após a inoculação, com destaque para o nível de 20 g kg-1 de solo que possibilitou reduzir a população do nematoide (FR=0,00). Com 5 g de fitomassa seca, em cobertura, de T. diversifolia foi possível reduzir 2,96 % a população do nematoide, enquanto que os níveis de fitomassa seca de 10, 15 e 20 g kg-1 de solo eliminou o patógeno. Conclui-se que a incorporação ao solo de folhas frescas de T. diversifolia, e a cobertura morta com folhas de T. diversifolia sobre o solo, na forma de fitomassa seca, proporcionaram redução na população de P. brachyurus no solo e nas raízes de quiabeiro, sendo uma alternativa importante para o manejo de P. brachyurus

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“…Although there is no phytochemical or pharmacological knowledge about S. yucatanensis, it has been reported that the extract of Serjania erecta has anti-inflammatory and nematicidal activities (Gomig et al 2006;Slomp et al 2009) and that the extract of Serjania glabrata has antioxidant activity (Meira et al 2007). Additionally, phytochemical studies carried out in species of the Sapindaceae family report the presence of alkaloids, tannins, fenols, saponins, terpenes, and flavonoids (Carretero Acame 2001; Marrero et al 2004).…”

Section: Discussionmentioning

confidence: 98%

In vitro and in vivo trypanocidal activity of native plants from the Yucatan Peninsula

et al. 2011

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Ethanol extracts of Senna villosa, Serjania yucatanensis, Byrsonima bucidaefolia, and Bourreria pulchra were evaluated for their in vitro activity against epimastigotes and trypomastigotes of Trypanosoma cruzi. Results showed that the leaf extracts of S. yucatanensis and B. pulchra were the most active against epimastigotes (IC(100) = 100 μg/mL) and trypomastigotes of T. cruzi (95% or more reduction in the number of parasites at 100 and 50 μg/mL). However, only the leaf extract of S. yucatanensis showed significant trypanocidal activity when tested in vivo, reducing 75% of the parasitemia in infected mice at 100 mg/kg. This same extract inhibited the egress of trypomastigotes from infected cells and proved not to be cytotoxic (IC(50) = 318.8 ± 2.3 μg/mL).

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In vitronematocidal effects of medicinal plants from São Paulo state, Brazil

Cited by 18 publications

References 19 publications

In vitro anthelmintic activity of aqueous leaf extract of Annona muricata L. (Annonaceae) against Haemonchus contortus from sheep

In vitro anthelmintic activity of aqueous leaf extract of Annona muricata L. (Annonaceae) against Haemonchus contortus from sheep

Folhas de girassol mexicano como alternativa no manejo de Pratylenchus brachyurus em quiabeiro

In vitro and in vivo trypanocidal activity of native plants from the Yucatan Peninsula

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