<i>In vitro</i> selection of an RNA aptamer yields an interleukin-6/interleukin-6 receptor interaction inhibitor

Ando, Tetsu; Takamori, Yukio; Tsukamoto, Keita; Fuji, Daisuke; Kawakami, Takashi

doi:10.1093/bbb/zbaa124

Cited by 8 publications

(1 citation statement)

References 22 publications

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“…They also demonstrated that their DNA aptamer-gold nanostar conjugate can stop virus infection by blocking the ACE2 receptor-binding capability while destroying the lipid membrane of the virus. Interestingly, Ando et al [ 215 ] propose the use of an IL-6/IL-6 receptor interaction inhibitor as a possible therapeutic against COVID-19. The IL-6 binding to the IL-6R sub-unit has been implicated in cytokine storm occurrence in the COVID-19 pathology.…”

Section: Discussionmentioning

confidence: 99%

Aptamers in Virology—A Consolidated Review of the Most Recent Advancements in Diagnosis and Therapy

2021

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The use of short oligonucleotide or peptide molecules as target-specific aptamers has recently garnered substantial attention in the field of the detection and treatment of viral infections. Based on their high affinity and high specificity to desired targets, their use is on the rise to replace antibodies for the detection of viruses and viral antigens. Furthermore, aptamers inhibit intracellular viral transcription and translation, in addition to restricting viral entry into host cells. This has opened up a plethora of new targets for the research and development of novel vaccines against viruses. Here, we discuss the advances made in aptamer technology for viral diagnosis and therapy in the past decade.

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Section: Discussionmentioning

confidence: 99%