<i>In vitro</i> studies of platelet adhesion, activation, and protein adsorption on curcumin‐eluting biodegradable stent materials

Pan, Changjiang; Shao, Zhen Yi; Tang, Jia Ju; Wang, Junfeng; Huang, Nan

doi:10.1002/jbm.a.31108

Cited by 22 publications

(21 citation statements)

References 31 publications

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“…CUR has been shown to possess adsorption potential and has been extensively used for controlled delivery of protein molecules [15]. Adsorption properties can be employed in increasing the local (oral) availability of CUR at the site of action and preventing initiation of biofilm formation on tissue surfaces and prosthetic devices.…”

Section: Discussionmentioning

confidence: 99%

Utilising polyphenols for the clinical management of Candida albicans biofilms

Shahzad

Sherry

Rajendran

et al. 2014

International Journal of Antimicrobial Agents

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Section: Discussionmentioning

confidence: 99%

Utilising polyphenols for the clinical management of Candida albicans biofilms

Shahzad

Sherry

Rajendran

et al. 2014

International Journal of Antimicrobial Agents

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“…These disadvantages usually limited its applications in medicine fields. In order to enhance its therapeutic effects, curcumin was incorporated in microgels, hydrogel, porous sponge scaffold, nanofibers and so on [5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Fabrication and characterization of curcumin-loaded silk fibroin/P(LLA-CL) nanofibrous scaffold

et al. 2014

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Curcumin exhibited excellent properties including antioxidant, antiinflammatory, antiviral, antibacterial, antifungal, anticancer, and anticoagulant activities. In this study, curcumin was incorporated into silk fibroin (SF)/poly(L-lactic acid-co-ecaprolactone) (P(LLA-CL)) nanofibrous scaffolds via electrospinning, and changes brought about by raising the curcumin content were observed: SEM images showed that the average nanofibrous diameter decreased at the beginning and then increased, and the nanofibers became uniform; FTIR showed that the conformation of SF transforming from random coil form to β-sheet structure had not been induced, while SF conformation converted to β-sheet after being treated with 75% ethanol vapor; XRD results confirmed that the crystal structure of (P(LLA-CL)) had been destroyed; The mechanical test illustrated that nanofibrous scaffolds still maintained good mechanical properties. Further, curcumin-loaded nanofibrous scaffolds were evaluated for drug release, antioxidant and antimicrobial activities in vitro. The results showed that curcumin presented a sustained release behavior from nanofibrous scaffolds and maintained its free radical scavenging ability, and such scaffolds could effectively inhibit S. aureus growth ( > 95%). Thus, curcumin-loaded SF/P(LLA-CL) nanofibrous scaffolds might be potential candidates for wound dressing and tissue engineering scaffolds.

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“…These features are now moving the development of silk protein from a suture material to a building block for many biomedical applications including tissue engineering and drug delivery [5, 6]. Many in vitro studies have proposed the use of silk for vascular applications; for example, as a stent coating for sustained drug release [7], in blood vessel engineering [8], and as a material for small vascular grafts [9]. However, only a small number of studies have tested in vivo vascular applications of silk [9-11].…”

Section: Introductionmentioning

confidence: 99%

Multifunctional silk–heparin biomaterials for vascular tissue engineering applications

et al. 2014

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Over the past 30 years, silk has been proposed for numerous biomedical applications that go beyond its traditional use as a suture material. Silk sutures are well tolerated in humans, but the use of silk for vascular engineering applications still requires extensive biocompatibility testing. Some studies have indicated a need to modify silk to yield a hemocompatible surface. This study examined the potential of low molecular weight heparin as a material for refining silk properties by acting as a carrier for vascular endothelial growth factor (VEGF) and improving silk hemocompatibility. Heparinized silk showed a controlled VEGF release over 6 days; the released VEGF was bioactive and supported the growth of human endothelial cells. Silk samples were then assessed using a humanized hemocompatibility system that employs whole blood and endothelial cells. The overall thrombogenic response for silk was very low and similar to the clinical reference material polytetrafluoroethylene. Despite an initial inflammatory response to silk, apparent as complement and leukocyte activation, the endothelium was maintained in a resting, anticoagulant state. The low thrombogenic response and the ability to control VEGF release support the further development of silk for vascular applications.

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In vitro studies of platelet adhesion, activation, and protein adsorption on curcumin‐eluting biodegradable stent materials

Cited by 22 publications

References 31 publications

Utilising polyphenols for the clinical management of Candida albicans biofilms

Utilising polyphenols for the clinical management of Candida albicans biofilms

Fabrication and characterization of curcumin-loaded silk fibroin/P(LLA-CL) nanofibrous scaffold

Multifunctional silk–heparin biomaterials for vascular tissue engineering applications

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