In vitro studies on the selective cytotoxic effect of luminescent Ru(ii)-p-cymene complexes of imidazo-pyridine and imidazo quinoline ligands

Abstract

In recent years, Ru(II) complexes have high importance in medicinal chemistry due to their significant anti-cancer activities which are directly related to DNA binding ability. In this report, chemistry and...

Half-Sandwich Iridium(III), Rhodium(III), and Ruthenium(II) Complexes Chelating Hybrid sp2-N/sp3-N Donor Ligands to Achieve Improved Anticancer Selectivity

“…310 and 370 nm were observed, respectively. These absorption bands below 300 nm can be attributed to spin-allowed ligand-centered π–π* transitions and the absorption bands between 300 and 450 nm were considered to be associated with charge transfer or d–d transitions, which is similar to some reported half-sandwich Ir­(III), Rh­(III), and Ru­(II) complexes. − …”

“…). These values were lower than those of halfsandwich complexes in earlier reports (K b > 10 5 M −1 ), 22,52,54 indicating that these imine−amine complexes exhibited a relatively weak interaction with CT-DNA. Moreover, the binding affinity followed the order of Rh1 > Ru1 > Ir7 > Ir4 > Ir1, which was not correlated with their cytotoxicity toward cancer cells.…”

“…The calculated K b values for these imine–amine complexes were in the range from 4.31 × 10 3 to 5.61 × 10 4 M –1 ( Ir1 : K b = 4.31 × 10 3 M –1 , Ir4 : K b = 8.74 × 10 3 M –1 , Ir7 : K b = 1.07 × 10 4 M –1 , Rh1 : K b = 5.61 × 10 4 M –1 , Ru1 : K b = 3.51 × 10 4 M –1 ). These values were lower than those of half-sandwich complexes in earlier reports ( K b > 10 5 M –1 ), ,, indicating that these imine–amine complexes exhibited a relatively weak interaction with CT-DNA. Moreover, the binding affinity followed the order of Rh1 > Ru1 > Ir7 > Ir4 > Ir1 , which was not correlated with their cytotoxicity toward cancer cells.…”

Potent Half-Sandwich 16-/18-Electron Iridium(III) and Ruthenium(II) Anticancer Complexes with Readily Available Amine–Imine Ligands

“…Additionally, the absorption bands between 320 and 490 nm can be attributed to spin-allowed charge transfer from metal to ligand. Notably, the absorption behavior of these complexes was similar to that of earlier reported half-sandwich iridium­(III) and ruthenium­(II) complexes. − …”

GSH resistant, luminescent 2-(pyren-1-yl)-1H-imidazo[4,5-f][1,10]phenanthroline-based Ru(ii)/Ir(iii)/Re(i) complexes for phototoxicity in triple-negative breast cancer cells

“…47,48 In this study, the binding affinity of DNA towards complexes was monitored by UV-visible spectroscopy. 49 These complexes exhibited a hypochromic shift in absorbance in π–π* region with increasing DNA concentration from 0–60 μM (Tris-HCl buffer, pH 7.8, t = 25 °C) (Fig. S9†).…”