<i>In Vitro</i>Studies on the Release of Isoniazid Incorporated in Poly(ε-Caprolactone)

Duran, Nizami; Oliveira, André Fernando de; Azevedo, Marcelo Mantovani Martiniano de

doi:10.1179/joc.2006.18.5.473

Cited by 11 publications

(4 citation statements)

References 19 publications

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“…the matrix together with the drug [100]. The same trend was reported in the study conducted by Kheiri Manjili et al [101] and Zamani et al [102].…”

Section: Drug Release Analysissupporting

confidence: 80%

“…The low rate occurred because the release behavior is not severely affected by the degradation of PCL blocks, as the PCL degradation rate is very slow in an aqueous medium due to crystalline and hydrophobic properties. Hence, the release of ciprofloxacin was facilitated by the penetration of water into the amorphous region of the polymer matrix that diffuses out of the matrix together with the drug [100]. The same trend was reported in the study conducted by Kheiri Manjili et al [101] and Zamani et al [102].…”

Section: Drug Release Analysissupporting

confidence: 70%

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Hydrophobic Drug Carrier from Polycaprolactone-b-Poly(Ethylene Glycol) Star-Shaped Polymers Hydrogel Blend as Potential for Wound Healing Application

et al. 2023

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Blending hydrogel with an amphiphilic polymer can increase the hydrophobic drug loading and entrapment efficiency of hydrogel-based formulations. In this study, a hydrogel formulation with star-shaped polycaprolactone-b-poly(ethylene glycol) (PCL-b-PEG) as the hydrophobic drug cargo is produced. The 4-arm and 6-arm star-shaped PCL are synthesized with different molecular weights (5000, 10,000, 15,000 g/mol) via ROP and MPEG as the hydrophilic segment is attached via the Steglich esterification. FTIR and 1H-NMR analysis showed the presence of all functional groups for homopolymers and copolymers. Mn for all synthesized polymers is close to the theoretical value while GPC spectra showed a monomodal peak with narrow molecular weight distribution (PDI:1.01–1.25). The thermal degradation temperature and crystalline melting point of synthesized polymers increase with the increase in molecular weight and number of arms. All formulations possess high drug loading and entrapment efficiency (>99%) and increase with increasing molecular weight, number of arms, and amount of polymer in the formulations. All formulations showed a sustained drug release pattern with no initial burst, which follows the Korsmeyer–Peppas kinetic model. The polymer hydrogel formulations showed antibacterial activity against E. coli and S. aureus. The hydrogel containing 4-arm PCL15k-PEG is chosen as the best formulation due to its high drug release, good antimicrobial activity, and morphology.

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“…the matrix together with the drug [100]. The same trend was reported in the study conducted by Kheiri Manjili et al [101] and Zamani et al [102].…”

Section: Drug Release Analysissupporting

confidence: 80%

Section: Drug Release Analysissupporting

confidence: 70%

Hydrophobic Drug Carrier from Polycaprolactone-b-Poly(Ethylene Glycol) Star-Shaped Polymers Hydrogel Blend as Potential for Wound Healing Application

et al. 2023

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“…The effect of nanoencapsulation of RIF in PLGA on the antibacterial activity of RIF against gram-positive and gram-negative bacteria was evaluated and it was shown that RIF nanoparticles could considerably improve the RIF antibacterial efficacy (Pandey et al, 2003;Esmaili et al, 2007). Similar effect for isoniazid encapsulation in poly(ε-caprolactone) (PCL) was observed (Durán et al, 2006). A study with a murine tuberculosis model using oral PLGA nanoparticle with encapsulated ethambutol in combination with RIF, isoniazid and pyrazinamide showed that the polymeric nanoparticle based oral four-drug combination has significant potential to shorten the duration of tuberculosis chemotherapy as well to reduce the dosing frequency (Pandey et al, 2006a;Pandey et al, 2006b).…”

Section: Introductionmentioning

confidence: 61%

Microencapsulation of antibiotic rifampicin in poly(3-hydroxybutyrate-co-3-hydroxyvalerate)

et al. 2008

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The aim of this study was the preparation of microparticles containing rifampicin using a biodegradable polymer poly(3-hydroxybutyrate-co-3-hydroxyvalerate) for oral administration produced by a bacteria. The poly(3-hydroxybutyrate-co-3-hydroxyvalerate) microparticles with and without rifampicin were prepared by the emulsification and solvent evaporation method, in which chloroform and polyvinyl alcohol are used as the solvent and emulsifier, respectively. Microparticles were obtained within a size range of 20-60 microm by changing the initial poly(3-hydroxybutyrate-co-3-hydroxyvalerate), polyvinyl alcohol and rifampicin concentrations. An encapsulation efficiency value of 14% was obtained. The optimized total yield of 60% of the poly(3-hydroxybutyrate-co-3-hydroxyvalerate)/ rifampicin was obtained. A load of 0.035 mg/1 mg of PHBV was reached. Almost 90% of the drug loaded in the microparticles was released after 24 h. The size, encapsulation efficiency and ribampicin release of the microparticles varied as a function of the initial poly(3-hydroxybutyrate-co-3-hydroxyvalerate), polyvinyl alcohol and rifampicin concentrations. It was demonstrated that the microencapsulated rifampicin, although was not totally available in the medium, exhibited a similar inhibition value as free rifampicin at 24 h of incubation with S. aureus. Cytotoxicity assays demonstrated a reduction of the toxicity when rifampicin was microencapsulated in poly(3-hydroxybutyrate-co-3-hydroxyvalerate) while maintaining its antibacterial activity.

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“…Poly- ε -caprolactone (PCL) is a biocompatible, biodegradable, semicrystalline FDA-approved aliphatic polyester that degrades slowly and, unlike polylactide (PLA) or polyglycolide (PLG) polymers [61, 62], has been used to prepare microparticles by the oil-in-water (O/W) emulsion-solvent. These microparticles were synthesized as a long-acting delivery system for this opioid antagonist [63–65] since they deliver pharmacologically active naloxone at a constant rate for at least 7 days [66].…”

Section: Treatmentsmentioning

confidence: 99%

Opioid Addiction: Social Problems Associated and Implications of Both Current and Possible Future Treatments, including Polymeric Therapeutics for Giving Up the Habit of Opioid Consumption

Benéitez

Gil-Alegre

2017

BioMed Research International

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Background Detoxification programmes seek to implement the most secure and compassionate ways of withdrawing from opiates so that the inevitable withdrawal symptoms and other complications are minimized. Once detoxification has been achieved, the next stage is to enable the patient to overcome his or her drug addiction by ensuring consumption is permanently and completely abandoned, only after which can the subject be regarded as fully recovered. Methods A systematic search on the common databases of relevant papers published until 2016 inclusive. Results and Conclusion Our study of the available oral treatments for opioid dependence has revealed that no current treatment can actually claim to be fully effective. These treatments require daily oral administration and, consequently, regular visits to dispensaries, which in most cases results in a lack of patient compliance, which causes fluctuations in drug plasma levels. We then reviewed alternative treatments in the available scientific literature on polymeric sustained release formulations. Research has been done not only on release systems for detoxification but also on release systems for giving up the habit of taking opioids. These efforts have obtained the recent authorization of polymeric systems for use in patients that could help them to reduce their craving for drugs.

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In VitroStudies on the Release of Isoniazid Incorporated in Poly(ε-Caprolactone)

Cited by 11 publications

References 19 publications

Hydrophobic Drug Carrier from Polycaprolactone-b-Poly(Ethylene Glycol) Star-Shaped Polymers Hydrogel Blend as Potential for Wound Healing Application

Hydrophobic Drug Carrier from Polycaprolactone-b-Poly(Ethylene Glycol) Star-Shaped Polymers Hydrogel Blend as Potential for Wound Healing Application

Microencapsulation of antibiotic rifampicin in poly(3-hydroxybutyrate-co-3-hydroxyvalerate)

Opioid Addiction: Social Problems Associated and Implications of Both Current and Possible Future Treatments, including Polymeric Therapeutics for Giving Up the Habit of Opioid Consumption

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