In vitrostudy of chitosan-based multi-responsive hydrogels as drug release vehicles: a preclinical study

Abstract

Pictorial diagram of multi-responsive hydrogels for controlled drug release system.

Supramolecular Structure of Temperature‐Dependent Polymeric Hydrogels Modulated by Drug Incorporation

“…In fact, the use of smart polymeric materials with accurate physico-chemical characterization is essential for the design of new pharmaceutical formulations during the early stages of the development, since it is possible to establish a relationship between the supramolecular structure responsible for the best performance as drug-delivery system and the main factors involved in this process (temperature and pH-induced drug release, additives like other polymers and drugs). [6][7][8][10][11] However, literature studies on these polymeric systems lack on structural characterization, particularly regarding scattering techniques, which could provide important information on the structural phase organization, essential to improve physicochemical stability and thus enhance therapeutic efficacy. [15][16][17] In this context, Small Angle Neutron Scattering (SANS) is a powerful technique to understand the structural arragements in the gels after incorporation of drugs with different physicochemical features.…”

“…Also called as smart polymers, they have been extensively reported in the literature due to their self‐assembly capability in aqueous medium, leading to distinct phase‐behaviors in response to environmental conditions [1–5] . In general, pH‐sensitive systems have been frequently studied, specially chitosan‐based systems (vinyltrimethoxy silane cross‐linked chitosan/polyvinylpyrrolidone; 2‐aminobenzamide cross‐linked chitosan; carboxymethyl chitosan‐polyoxometalate) for drug‐delivery and tissue regeneration purposes [6–11] …”

“…Binary combinations of different types of PL highlight many possibilities regarding its supramolecular structure, increasing the potential for further biopharmaceutical applications. In fact, the use of smart polymeric materials with accurate physico‐chemical characterization is essential for the design of new pharmaceutical formulations during the early stages of the development, since it is possible to establish a relationship between the supramolecular structure responsible for the best performance as drug‐delivery system and the main factors involved in this process (temperature and pH‐induced drug release, additives like other polymers and drugs) [6–8,10–11] …”

“…[1][2][3][4][5] In general, pHsensitive systems have been frequently studied, specially chitosan-based systems (vinyltrimethoxy silane cross-linked chitosan/polyvinylpyrrolidone; 2-aminobenzamide cross-linked chitosan; carboxymethyl chitosan-polyoxometalate) for drugdelivery and tissue regeneration purposes. [6][7][8][9][10][11] Regarding to thermosensitive systems, one of the main classes of stimuli-responsive copolymers are poloxamers or Pluronics® (PL), smart materials highly responsive to temperature. Pluronics® (PL) are copolymers composed of polyethylene oxide (PEO) and polypropylene oxide (PPO) blocks linked as an AÀ BÀ A type structure.…”

Chitosan-g-oligo/polylactide copolymer non-woven fibrous mats containing protein: from solid-state synthesis to electrospinning

“…14,15 Natural polymers have a diverse set of functions in their native setting, and are widely used for pharmaceutical and medical applications mostly due to their biodegradability and good cell adhesion. [16][17][18][19] For example, collagen and gelatin are important components in tissue and organ development and regeneration. They possess an ability to form complexes with polyions that makes these polymers attractive for drug delivery and tissue engineering applications.…”