2006
DOI: 10.1002/yea.1389
|View full text |Cite
|
Sign up to set email alerts
|

In vitro synergistic effect of farnesol and human gingival cells against Candida albicans

Abstract: Farnesol prevents the germination of yeast cells into mycelia, a fact that may be useful in eliminating C. albicans pathogenicity. Given the clinical potential of farnesol, its impact on C. albicans and host cells merited further investigation. We thus studied the effect of farnesol on C. albicans growth and filamentation and on gingival epithelial cells and fibroblasts and the synergistic effect of both gingival cells and farnesol on C. albicans filamentation. Repeated additions of farnesol reduced the growth… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

3
14
0

Year Published

2007
2007
2015
2015

Publication Types

Select...
6
2

Relationship

0
8

Authors

Journals

citations
Cited by 21 publications
(17 citation statements)
references
References 53 publications
3
14
0
Order By: Relevance
“…For instance, Cole et al (10) describe the likely intercellular transmigration (termed persorption) whereby yeast cells of C. albicans cross the mucosal barrier into the bloodstream. As another case in point, Saidi et al (40) found that gingival fibroblasts lost viability when treated with Ͼ10 M farnesol. Third, if farnesol contributes to the lysis of even a few red blood cells, the iron made available could enhance pathogenicity.…”
Section: Discussionmentioning
confidence: 97%
“…For instance, Cole et al (10) describe the likely intercellular transmigration (termed persorption) whereby yeast cells of C. albicans cross the mucosal barrier into the bloodstream. As another case in point, Saidi et al (40) found that gingival fibroblasts lost viability when treated with Ͼ10 M farnesol. Third, if farnesol contributes to the lysis of even a few red blood cells, the iron made available could enhance pathogenicity.…”
Section: Discussionmentioning
confidence: 97%
“…The cultures were incubated at 37°C, observed microscopically at 6 and 24 h, and photographed to record C. albicans morphology. To calculate the percentage of yeast cells that underwent the morphological transition, three aliquots from each culture (n = 5) were used to determine the number of yeast cells and hyphae by means of a haemocytometer and an optical microscope, as previously described [32]. The percentage of cells that underwent morphological transition was determined using the following formula: (number of hyphae divided by the number of yeast cells and hyphae) × 100.…”
Section: Methodsmentioning
confidence: 99%
“…It furthermore inhibits IL-6 cytokine production in murine macrophages, a key cytokine in mucosal and systemic C. albicans infections, and induces apoptosis of macrophages (Abe et al, 2009;Conti et al, 2009;Ghosh et al, 2010). In contrast to its function as a virulence factor in a systemic model, exogenously added farnesol exerted a protective effect on cells in a reconstituted human epithelial (RHE) model and in a mouse model of oral candidiasis (Hisajima et al, 2008;Saidi, Luitaud, & Rouabhia, 2006). Here, farnesol increased TLR2 expression levels, promoted IL-6 secretion and increased the production of the AMP b-defensin 2 (Decanis, Savignac, & Rouabhia, 2009).…”
Section: Effects Of Quorum Sensing During Infectionmentioning
confidence: 98%