2019
DOI: 10.1101/518050
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In vitro synergy between Sodium Deoxycholate and Furazolidone against Enterobacteria via Inhibition of Multidrug Efflux Pumps

Abstract: 21Antimicrobial combinations have been proven to be a promising approach in the 22 confrontation with multi-drug resistant bacterial pathogens, owing to enhancement of 23 antibacterial efficacy, deceleration of resistance development rate and mitigation of side 24 effects by lowering the doses of two drugs. In the present study, we report that combination 25 of furazolidone (FZ) and other nitrofurans with a secondary bile salt, Sodium Deoxycholate 26 (DOC), generates a profound synergistic effect on growth inh… Show more

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