<i>In vitro</i>uptake and release of natamycin Dex<i>-b-</i>PLA nanoparticles from model contact lens materials

Phan, Chau-Minh; Subbaraman, Lakshman N.; Liu, Shengyan; Gu, Frank; Jones, Lyndon

doi:10.1080/09205063.2013.830914

Cited by 37 publications

(58 citation statements)

References 48 publications

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“…Numerous synthetic and natural polymeric materials, including biodegradable, biocompatible and non-biodegradable substances, have already been used for nanoparticle preparation. Among the synthetic biodegradable polymeric matrices, poly(lactide-co-glycolide) (PLGA) [26,28,34] and poly(D, L-lactide) (PLA) [35] are the most common. Polymeric materials such as poly(methylmethacrylate) (PMMA) [36] and poly(ethylene-co-vinyl acetate) (PEVA) [12] are characterized by satisfying biocompatibility.…”

Section: Classification and Properties Of Polymeric Nanoparticlesmentioning

confidence: 99%

“…Curiously, drug-loaded polymeric nanoparticles incorporated into other matrices (e.g. synthetic polymers) can consist of a component of materials designed for biomedical applications [35].…”

Section: Classification and Properties Of Polymeric Nanoparticlesmentioning

confidence: 99%

“…The authors highlighted the potential of the as-prepared system for the food industry to help prevent foodborne diseases [21]. Interesting studies have been conducted by Phan and co--workers [35], who have examined the use of natamycin-loaded nanoparticles composed of dextran and poly(D, L-lactide) (Dex-b-PLA) for the surface modification of contact lenses fabricated from various polymeric materials. It has been found that extended drug release up to 12 h was observed for contact lens materials composed of N, N-dimethylacrylamide or [tris(trimethylsiloxy)silyl]-propyl methacrylate.…”

Section: Polymeric Nanoparticles As Carriers For Therapeutic Agentsmentioning

confidence: 99%

“…It has been found that extended drug release up to 12 h was observed for contact lens materials composed of N, N-dimethylacrylamide or [tris(trimethylsiloxy)silyl]-propyl methacrylate. The authors suggested that natamycin-loaded Dex-b-PLA nanoparticles incorporated into contact lens materials have the potential to be used for targeted drug delivery directly to the cornea for the treatment of fungal infections [35]. Another group [25] has prepared voriconazole-loaded PLGA nanoparticles for pulmonary drug delivery.…”

Section: Polymeric Nanoparticles As Carriers For Therapeutic Agentsmentioning

confidence: 99%

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Recent Developments in Application of Polymeric Nanoparticles as Drug Carriers

Moritz¹,

Geszke-Moritz²

2015

Adv Clin Exp Med

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Nanotechnology is an interdisciplinary field of science offering interesting solutions for many branches of human life. Nanomaterials, defined as structures with at least one dimension below 100 nm, are the focus of increasing research attention as versatile tools for nanomedicine. Among the various nanostructures recently described in the literature, polymeric nanoparticles, characterized by satisfying biocompatibility, have aroused great interest as the carriers for various biologically active substances such as drugs, proteins and nucleic acids. These nanoparticles have already been reported as efficient vehicles for therapeutic agents in many disease entities. They can be delivered to the body via different administration routes. This review addresses recent advances in the usage of polymeric nanoparticles as drug carriers described in the years 2013 and 2014. The advantages of polymeric nanocarriers for medical application are highlighted, including their low toxicity, evaluated in vitro and in vivo. Moreover, the classification of polymeric nanoparticles is presented as well as various protocols of their synthesis (Adv Clin Exp Med 2015, 24, 5, 749-758).

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Section: Classification and Properties Of Polymeric Nanoparticlesmentioning

confidence: 99%

Section: Classification and Properties Of Polymeric Nanoparticlesmentioning

confidence: 99%

Section: Polymeric Nanoparticles As Carriers For Therapeutic Agentsmentioning

confidence: 99%

Section: Polymeric Nanoparticles As Carriers For Therapeutic Agentsmentioning

confidence: 99%

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Recent Developments in Application of Polymeric Nanoparticles as Drug Carriers

Moritz¹,

Geszke-Moritz²

2015

Adv Clin Exp Med

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“…3 Using nanoparticles/ colloid carriers to increase the release duration from the contact lenses has also been proposed by some other authors. [33][34][35][36] …”

mentioning

confidence: 99%

Ocular Drug Delivery Role of Contact Lenses

Chauhan¹

2015

DJO

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Development of biodegradable polymeric nanoparticles for encapsulation, delivery, and improved antifungal performance of natamycin

Bouaoud

Mendes

et al. 2016

J of Applied Polymer Sci

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The aim of this study was to evaluate biodegradable poly(lactide-co-glycolide) nanoparticles as potential nano-delivery systems for the food antifungal compound natamycin. Natamycin-loaded nanoparticles were prepared at various ratios polymer/antifungal by the nanoprecipitation technique, resulting in nano-size particles (80-120 nm) with a narrow distribution and a spherical morphology. Complexation of natamycin with PLGA and active participation to the nanoparticle formation were evidenced by a mean diameter reduction of 10-30 nm, although encapsulation levels remained low due to the zwitterionic and partially hydrophilic nature of natamycin. Physical state analyses highlighted the presence of natamycin in an amorphous or molecularly dispersed state within the polymeric matrix. This translates into high availability of free antifungal molecules reflected in burst release and fast in vitro release kinetics rates as well as enhanced antifungal performance against the model food yeast Saccharomyces cerevisiae, offering a potential benefit for antifungal protection compared with the commercially available natamycin products. V C 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016, 133, 43736.

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In vitrouptake and release of natamycin Dex-b-PLA nanoparticles from model contact lens materials

Abstract: Model CL materials loaded with natamycin-Dex-b-PLA NPs were able to release natamycin for up to 12 h under infinite sink conditions. DMAA-TRIS materials may be more suitable for drug delivery of natamycin due to the higher drug release observed with these materials.

Cited by 37 publications

References 48 publications

Recent Developments in Application of Polymeric Nanoparticles as Drug Carriers

Recent Developments in Application of Polymeric Nanoparticles as Drug Carriers

Ocular Drug Delivery Role of Contact Lenses

Development of biodegradable polymeric nanoparticles for encapsulation, delivery, and improved antifungal performance of natamycin

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