In Vivo Aggregation of Clearable Bimetallic Nanoparticles with Interlocked Surface Motifs for Cancer Therapeutics Amplification

Abstract

Although renal-clearable luminescent metal nanoparticles (NPs) have been widely developed, their application to efficient cancer therapy is still limited due to low reactive oxygen species (ROS) production. Here, a novel system of clearable mercaptosuccinic acid (MSA) coated Au−Ag bimetallic NPs is designed to enhance ROS production. The results show that the strong COO−Ag coordination bonds between the carboxylic acid groups of MSA and Ag atoms on the Au−Ag bimetallic NPs could construct high-rigidity interlocked surface motifs to restrict the intrananoparticle motions for enhanced ROS generation. Moreover, bimetallic NPs exhibit pH-responsive self-assembly capability under the acidic environment inside lysosomes of cancer cells at both in vitro and in vivo, restricting the internanoparticle motions to further boost ROS production. The well-designed bimetallic NPs show high tumor targeting efficiency, fast elimination from the body through rapid liver biotransformation, and extensive destruction to cancer cells, resulting in good security and prominent therapeutic performance.

Unveiling the Impact of Light-Induced Acceptor-Generated ROS on Device Stability in Organic Photovoltaics

“…38 Therefore, the lack of a clear orientation in LC8 may be attributed to the excessive tendency for aggregation, leading to rapid molecular accumulation. On the other hand, this strong tendency for aggregation in LC8 may act as a detrimental factor in the photoinduced generation of ROS, 39,40 further leading to the self-degradation of the acceptor.…”

Self‐Assembly of 2D Polyphthalocyanine in Lysosome Enables Multienzyme Activity Enhancement to Induce Tumor Ferroptosis

“…[12] More recently, Tang et al found mercaptosuccinic acid (MSA) coated Au−Ag bimetallic NPs exhibited pH-responsive self-assembly capability by hydrogen bonding of carboxylic acid groups (O−H•••O) under the acidic environment inside lysosomes of cancer cells to enhance ROS production. [13] Furthermore, Cao and colleagues summarized the lysosomal targeting strategies including targeting lysosomal acidification, targeting lysosomal membrane permeability and integrity, and so on. [14] Excitingly, targeting lysosomal acidification has been used to design abundant lysosomal targeted and self-assembled nanosystems for antitumor and imaging.…”