<i>In vivo</i> airway eosinophil accumulation induced by polymyxin‐B reduces bronchial responsiveness in guinea pigs

Ishiura, Yoshihisa; Fujimura, Masaki; Myou, Shigeharu; Nobata, Kouichi; Liu, Q.; Yamamori, Chihiro; Amemiya, Tokunao

doi:10.1046/j.1365-2222.2001.01107.x

Cited by 6 publications

(6 citation statements)

References 20 publications

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“…Ishiura et al reported that in vivo airway eosinophils accumulation did not worsen asthma physiology, i.e. bronchial responsiveness and allergic bronchoconstriction, in guinea pigs (15). Therefore, we speculate that eosinophil may not play a key role in the development of CS-AEP.…”

Section: Discussionmentioning

confidence: 63%

Acute Eosinophilic Pneumonia Following Cigarette Smoking: A Case Report Including Cigarette-Smoking Challenge Test.

Watanabe¹,

Fujimura

Kondo

et al. 2002

Intern. Med.

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A 21-year-old womanpresented with acute progressive dyspnea. Chest computed tomography (CT) revealed diffuse bilateral infiltrates.Based on the results of transbronchial lung biopsy (TBLB) and bronchoalveolar lavage fluid (BALF) and her clinical course, she was diagnosed as having acute eosinophilic pneumonia. Wesuspected that the disease was related to smoking because she had started smoking ten days before the onset of symptoms. Therefore, a cigarette-smoking challenge test was done with the patient's informed consent. After the challenge, eosinophilic pneumonia was documented by BALF and TBLB findings, which were similar to those detected on admission, without significant radiographic findings.

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Section: Discussionmentioning

confidence: 63%

Acute Eosinophilic Pneumonia Following Cigarette Smoking: A Case Report Including Cigarette-Smoking Challenge Test.

Watanabe¹,

Fujimura

Kondo

et al. 2002

Intern. Med.

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“…Most of the experience using aerosolized polymyxins is with colistin and is likely due to the fact that polymyxin B can lead more frequently than colistimethate sodium to release of histamine during nebulization and thus, bronchoconstriction. 38,39 …”

Section: Inhaled Polymyxins In Critically Ill Patientsmentioning

confidence: 99%

The Use of Intravenous and Aerosolized Polymyxins for the Treatment of Infections in Critically Ill Patients: A Review of the Recent Literature

Falagas¹,

Kasiakou²,

Tsiodras³

et al. 2006

Clinical Medicine & Research

144

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Intravenous and aerosolized polymyxins are being used increasingly, especially in the critical care setting, for treating patients with infections due to multidrug-resistant Gram-negative bacteria, mainly Acinetobacter baumannii and Pseudomonas aeruginosa. Recent literature suggests that intravenous colistin and polymyxin B have acceptable effectiveness for the treatment of patients with bacteremia, as well as infections of various systems and organs, including pneumonia, bacteremia, skin and soft tissue, and urinary tract infections. Although data from recent studies have suggested that the toxicity of intravenous polymyxins is probably less than reported in the older literature, caution should be taken to monitor the renal function of patients who receive these antibiotics.

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“…However, these associations with eosinophils are not proof of causation, and recent studies have questioned the role of the eosinophil as a harmful cell [49–52], and even suggested that eosinophils can act as bystanders [53] or part of complex cell interactions and repair mechanisms [24,35,54]. Recruitment of eosinophils is linked with Th2 immune responses [54–56], since eosinophil production and recruitment appear to be mediated by the Th2 cytokines IL‐5, IL‐4 and IL‐13 [57,58].…”

Section: The Eosinophil Hypothesismentioning

confidence: 99%

The allergen challenge

Hansel

Erin

Barnes

2002

Clin Experimental Allergy

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In vivo airway eosinophil accumulation induced by polymyxin‐B reduces bronchial responsiveness in guinea pigs

Abstract: These results suggest that in vivo airway eosinophils may reduce non-specific bronchial responsiveness through inhibitory or bronchoprotective prostanoids.

Cited by 6 publications

References 20 publications

Acute Eosinophilic Pneumonia Following Cigarette Smoking: A Case Report Including Cigarette-Smoking Challenge Test.

Acute Eosinophilic Pneumonia Following Cigarette Smoking: A Case Report Including Cigarette-Smoking Challenge Test.

The Use of Intravenous and Aerosolized Polymyxins for the Treatment of Infections in Critically Ill Patients: A Review of the Recent Literature

The allergen challenge

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