<i>In vivo</i>antimalarial activities of glycoalkaloids isolated from Solanaceae plants

Chen, Yan; Li, Shengyu; Sun, Feifei; Han, Han; Zhang, Xu; Fan, Yuying; Tai, Guihua; Zhou, Yuwei

doi:10.3109/13880200903440211

Cited by 54 publications

(44 citation statements)

References 41 publications

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“…Drug resistance is a major problem associated with the failure of treatment of human infections caused by this type of parasite and underscores the importance of the development of novel drugs (21)(22)(23). Plant products have long been used in traditional medicine to treat different types of illnesses (2,(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18) and are now considered a good alternative for drug discovery. There are promising compounds originally isolated from plants with leishmanicidal properties, which could be antileishmanial drugs with commercial potential.…”

Section: Discussionmentioning

confidence: 99%

“…There are some other compounds with interesting possibilities for further development as antileishmanial drugs (24)(25)(26)(27). Compounds isolated from S. lycocarpum have already demonstrated great potential as antimicrobials and cytotoxic products (10)(11)(12)(13)(14)(15)(16)(17)(18). In particular, the glycoalkaloids from this plant present potent antimicrobial activity (11,13,(16)(17)(18).…”

Section: Discussionmentioning

confidence: 99%

“…(Solanaceae), also known as wolf fruit ("fruto-do-lobo"), have been used to treat a number of medical conditions. Preparations from this plant also display cytotoxic, antimicrobial, immunomodulatory, and antimutagenic activities (9)(10)(11)(12)(13)(14)(15)(16)(17)(18). We showed that alkaloids from this plant are lethal to Leishmania amazonensis promastigotes (9).…”

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confidence: 89%

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A New Antileishmanial Preparation of Combined Solamargine and Solasonine Heals Cutaneous Leishmaniasis through Different Immunochemical Pathways

Lezama-Dávila

McChesney

Bastos

et al. 2016

Antimicrob Agents Chemother

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Little has been done during the past 100 years to develop new antileishmanial drugs. Most infected individuals live in poor countries and have a low cash income to be attractive targets to pharmaceutical corporations. Two heterosidic steroids, solamargine and solasonine, initially identified as major components of the Brazilian plant Solanum lycocarpum, were tested for leishmanicidal activity. Both alkaloids killed intracellular and extracellular Leishmania mexicana parasites more efficiently than the reference drug sodium stibogluconate. A total of 10 M each individual alkaloid significantly reduced parasite counts in infected macrophages and dendritic cells. In vivo treatment of C57BL/6 mice with a standardized topical preparation containing solamargine (45.1%) and solasonine (44.4%) gave significant reductions in lesion sizes and parasite counts recovered from lesions. Alkaloids present different immunochemical pathways in macrophages and dendritic cells. We conclude that this topical preparation is effective and a potential new and inexpensive treatment for cutaneous leishmaniasis.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 89%

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A New Antileishmanial Preparation of Combined Solamargine and Solasonine Heals Cutaneous Leishmaniasis through Different Immunochemical Pathways

Lezama-Dávila

McChesney

Bastos

et al. 2016

Antimicrob Agents Chemother

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“…Patents that were reported, both in the European Patent Office and the Brazilian National Institute of industrial Property databases, most of which concern inflammatory, allergic, parasitic, infectious or digestive diseases, including extracts from P. angulata (Balbani et al, 2009 (Zakaria et al, 2006); can cause a central nervous system depression which may be correlated with an increased parasympathetic tone (Perez et al, 1998), antioxidant (Al-Fatimi et al, 2007); antipyretic and anticancer agent (Hsieh et al, 2008;Hsu et al, 2009;Yang et al, 2010;Li et al, 2008;Li et al, 2009), mutagenic activity (Almeida et al, 2010). Phytochemical: glycoalkaloids (El-Ashaal et al, 1999), tropane alkaloids (Oksman-Caldentey, 2007;Grynkiewicz & Gadzikowska, 2008;Nash et al, 1993), nicotine alkaloids (Oksman-Caldentey, 2007;Boswell et al, 1999), flavonoids (Wollenweber et al, 2005;Huang et al, 2010), sterols (Amir & Kumar, 2004), steroidal saponins (Ikeda et al, 2000;Nakamura et al, 2008;Zhou et al, 2006;Ferreira et al, 1996), pregnane saponins (Zhou et al, 2007), volatile oils and anthocyanins (Jainu & Devi, 2006), steroidal alkaloids, such as solamargine, solasonine and solanine (Sanchez-Mata, et al, 2010;Cornelius et al, 2010;Suthar & Mulani, 2008;Chen et al, 2010) and deacetoxysolaphyllidine-3-O-β-Dglucopyranoside (Colmenares et al, 2010); phenolic compounds with strong oxidative effects (Mimica-Dukic et al, 2005;Lin et al, 2007;Huang et al, 2010;…”

Section: Plants From Solanaceae Family With Possible Anxiolytic Effecmentioning

confidence: 99%

Plants from Solanaceae family with possible anxiolytic effect reported on 19th century's Brazilian medical journal

Giorgetti¹,

Negri²

2011

Rev. bras. farmacogn.

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Abstract:In the beginning of the 19 th century, the first Brazilian scientific knowledge journal on medicinal plants the Gazetas Médicas was launch reporting Brazilian medicinal plants belonging to several botanical families. The aim of this study was research the Solanaceae species that were described as anxiolytics in the 19 th century's Brazilian Medical Gazettes and to make a revision about these species in literature. A taxonomic update, together a careful research about ethnopharmacological, pharmacological and phytochemical, patent process and reports of phytomedicines, was carried out for these Solanaceae species. In this research were found thirteen plants, but the taxonomic update reduced this number to six species. Among them, Physalis angulata L. and Solanum nigrum L. were studied and showed depressor activity on central nervous system (CNS) as described in Gazetas Médicas. This research showed that Solanaceae species reported in this study has potential as anxiolytic drugs and should be investigated more deeply.

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“…Сре ди свойств СГА, значимых для данного направления: цито токсическое (Kenny et al, 2013), антигликемическое (Satoh, 1967), антиканцерогенное (Reddivari et al, 2010), противомалярийное (Chen et al, 2010), жаропонижающее и противовоспалительное действие (Choi, Koo, 2005;Del porte et al, 1998) .…”

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The Biosynthesis Regulation of Potato Steroidal Glycoalkaloids

Ivanova¹,

Gerasimova²,

Хлесткина³

2018

Vestn. VOGiS

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Potato steroidal glycoalkaloids (SGAs) compose a part of plant immunity. Some of their modified variants are toxic to humans. In the course of potato domestication, plants with a lower SGA level were selected. The advent of approaches for manipulation with the regulation of metabolic pathways provides an opportunity to overcome the undesirable direct relationship between the potato resistance to pests and the toxicity of its tubers. However, for such a fine regulation, a deep knowledge of the regulatory network of potato SGA biosynthesis is required. The purpose of this review is to summarize the information on the known SGA biosynthesis genes in plants and the results of the investigation of these genes in potato, as well as to consider the mechanisms of the SGA protective toxic action against pathogens and pests. The SGA biosynthesis is realized via the cytosolic mevalonate pathway and consists of three stages. The first two stages are required for the synthesis of primary metabolites, and lead to cycloartanol and cholesterol, respectively. Twelve enzymes are involved in the biosynthesis, and the half of them are involved in the biosynthesis of phytosterols, which is a branch of the first stage of this metabolic pathway. In the potato leaves with an excess of phytosterols, the synthesis switches to SGAs, increasing the content of the latter. In tubers, with an excess of SGA precursors, they are involved in the synthesis of lanosterol, supporting in this way the stable level of SGA. The importance of structural genes encoding the enzymes of the first two stages of biosynthesis does not allow us to consider them as a target for knockout in order to reduce the level of SGAs. However, information about the tissue-specific mechanisms of switching between the pathways of synthesis of SGA and other compounds having common precursors with SGAs can be used to manipulate the tissue-specific level of steroidal glycoalkaloids. At the third stage (the synthesis of glycoalkaloids from cholesterol), about 20 enzymes participate. In the potato genome, 14 corresponding genes were identified, 8 of which were studied in detail using reverse genetics approaches. As a promising target for reducing SGA levels in tubers, the genes encoding PGA enzymes (belonging to the CYP72 subfamily cytochrome-P450-dependent monooxygenases catalyzing the conversion of hydrocholesterol to trihydrocholesterol) and SGT (SGA glycosyltransferases that catalyze the conversion of solanidine to its toxic glycosylated derivatives α-solanine and α-chaconine) are considered. Cis-regulatory elements in the promoter regions of some glycoalkaloid biosynthesis genes, including elements responsible for tissue-specific expression, Стероидные гликоалкалоиды (СГА) картофеля составляют часть иммунитета растений. Некоторые их модифицированные фор-мы токсичны для человека. В ходе доместикации картофеля происходил отбор растений с пониженным уровнем СГА. В на-стоящее время с появлением методов, при помощи которых возможно специфично влиять на регуляцию метаболических пу...

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In vivoantimalarial activities of glycoalkaloids isolated from Solanaceae plants

Cited by 54 publications

References 41 publications

A New Antileishmanial Preparation of Combined Solamargine and Solasonine Heals Cutaneous Leishmaniasis through Different Immunochemical Pathways

A New Antileishmanial Preparation of Combined Solamargine and Solasonine Heals Cutaneous Leishmaniasis through Different Immunochemical Pathways

Plants from Solanaceae family with possible anxiolytic effect reported on 19th century's Brazilian medical journal

The Biosynthesis Regulation of Potato Steroidal Glycoalkaloids

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