In vivoassessment of antidiabetic and antioxidative activity of natural phytochemical isolated from fruit-pulp ofEugenia jambolanain streptozotocin-induced diabetic rats

Abstract

Objectives: Eugenia jambolana (E. jambolana) is well known for its antidiabetic potential. The aim of the present study was to investigate the antidiabetic and antioxidative effect of an active compound (FIIc) isolated from fruit-pulp of E. jambolana in streptozotocin (45 mg/kg body weight)-induced diabetic rats. Methods: FIIc was isolated from the crude aqueous extract of fruit-pulp by ion-exchange column chromatography and high-performance column chromatography. Detailed UV, NMR, and IR spectra suggested that FIIc is α-hydroxy succinamic acid. FIIc was orally administered to diabetic rats at a dose of 10, 15, and 20 mg/kg body weight (mg/kg bwt.) to determine its effective dose. Thereafter, effective dose was administered to 8 weeks to determine its antidiabetic and antioxidative activity by estimation of glycemic index, lipid profile, key enzymes of carbohydrate metabolism, and oxidative stress parameters. Results: Administration of 15 mg/kg dose daily for 8 weeks led to significant (P < 0.001) fall in fasting blood glucose. Treatment with FIIc (15 mg/kg bwt.) showed significant improvement (P < 0.001) in all the biochemical parameters.Discussion: The results demonstrate that FIIc possesses significant antidiabetic and antioxidative activity.

α-Amylase and dipeptidyl peptidase-4 (DPP-4) inhibitory effects of Melicope latifolia bark extracts and identification of bioactive constituents using in vitro and in silico approaches

“… 2014 ; Tanwar et al. 2017 ). Antioxidant compounds that occur in natural sources have thus garnered great attention and have been used to attenuate oxidative stress-induced diabetes (Unuofin and Lebelo 2020 ).…”

“…Numerous studies have reported that antioxidant compounds such as swertianin, 1,2-dihydroxy-6-methoxyxanthone-8-O-b-Dxylopyranosyl, and a-hydroxy succinamic acid protects b-cells from reactive oxygen species (ROS)-induced damage and consequently prevent diabetes (Mahendran et al 2014;Tanwar et al 2017). Antioxidant compounds that occur in natural sources have thus garnered great attention and have been used to attenuate oxidative stress-induced diabetes (Unuofin and Lebelo 2020).…”

Insights into the phenolic compounds present in jambolan (Syzygium cumini) along with their health‐promoting effects

“…Jambolan ethanolic pulp extract (prepared using 90% ethanol) at a level of 100 and 200 mg kg À1 day À1 have shown a considerable protection (reduced necrosis and fibrosis) against liver toxicity (induced by paracetamol) in albino rats (Das & Sarma, 2009). Jambolan fruit pulp extract (prepared using distilled water) has shown renal protective effect in streptozotocin-induced diabetic rats (Tanwar et al, 2017). Besides peel and pulp, jambolan seed extract proved effective for the treatment of liver injury.…”

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“…Jamun, Black plum, or Indian Blackberry are some of the common names 39 . Fruits are oval to elliptical, 1.5-3.5 cm long, dark purple or practically black in color, delicious, fleshy and edible 40 . Seeds, leaves, fruits, and bark are the most used plant parts.…”