<i>In vivo</i> astaxanthin treatment partially prevents antioxidant alterations in dental pulp from alloxan‐induced diabetic rats

Leite, Mariana Ferreira; Lima, Alessandro de; Massuyama, Monica Miyuki; Otton, Rosemari

doi:10.1111/j.1365-2591.2010.01707.x

Cited by 40 publications

(37 citation statements)

References 48 publications

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“…The results showed that although having no effect on superoxide dismutase and catalase activities, astaxanthin could stimulate glutathione peroxidase in control and diabetic rats and partially improved the diabetic complications [60]. In addition, Leite et al [68] also evaluated the effect of astaxanthin on the antioxidant enzymes of salivary gland from alloxan-induced diabetic rats, and showed that astaxanthin restored the enzymatic activities in the salivary gland.…”

Section: Dental Pulp and Salivary Glandmentioning

confidence: 96%

“…Leite et al [60] evaluated the effect of astaxanthin on antioxidant enzymes of dental pulp from alloxan-induced diabetic rats. The results showed that although having no effect on superoxide dismutase and catalase activities, astaxanthin could stimulate glutathione peroxidase in control and diabetic rats and partially improved the diabetic complications [60].…”

Section: Dental Pulp and Salivary Glandmentioning

confidence: 99%

“…Diabetes mellitus is strongly associated with oxidative stress, which can be a consequence of increased free radical production, reduced antioxidant defenses, or both [60]. Oxidative stress induced by hyperglycemia possibly causes the dysfunction of pancreatic b-cells and various forms of tissue damage in patients with diabetes mellitus [61].…”

Section: Diabetesmentioning

confidence: 99%

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Potential health‐promoting effects of astaxanthin: A high‐value carotenoid mostly from microalgae

Yuan

Peng

Yin

et al. 2010

Molecular Nutrition Food Res

555

309

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The ketocarotenoid astaxanthin can be found in the microalgae Haematococcus pluvialis, Chlorella zofingiensis, and Chlorococcum sp., and the red yeast Phaffia rhodozyma. The microalga H. pluvialis has the highest capacity to accumulate astaxanthin up to 4-5% of cell dry weight. Astaxanthin has been attributed with extraordinary potential for protecting the organism against a wide range of diseases, and has considerable potential and promising applications in human health. Numerous studies have shown that astaxanthin has potential health-promoting effects in the prevention and treatment of various diseases, such as cancers, chronic inflammatory diseases, metabolic syndrome, diabetes, diabetic nephropathy, cardiovascular diseases, gastrointestinal diseases, liver diseases, neurodegenerative diseases, eye diseases, skin diseases, exercise-induced fatigue, male infertility, and HgCl₂-induced acute renal failure. In this article, the currently available scientific literature regarding the most significant activities of astaxanthin is reviewed.

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Section: Dental Pulp and Salivary Glandmentioning

confidence: 96%

Section: Dental Pulp and Salivary Glandmentioning

confidence: 99%

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Potential health‐promoting effects of astaxanthin: A high‐value carotenoid mostly from microalgae

Yuan

Peng

Yin

et al. 2010

Molecular Nutrition Food Res

555

309

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show abstract

“…Except for its antioxidant capacity, AST is also recognized to have growth performance and survival rate promoting in Atlantic salmon (Salmo salar) (Christiansen and Torrissen 1996) and red porgy (Pagrus pagrus) (Kalinowski et al 2011), skins coloration enhancing in large yellow croaker (Larimichthys croceus) (Yi et al 2014) and Atlantic salmon (Baker et al 2002), anti-lipid peroxidation (Leite et al 2010), and immune response reinforcing in Astronotus ocellatus (Alishahi et al 2015) properties.…”

Section: Introductionmentioning

confidence: 99%

Effects of astaxanthin on antioxidant capacity of golden pompano (Trachinotus ovatus) in vivo and in vitro

et al. 2017

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The objective of this research was to study the effect of astaxanthin (AST) on growth performance and antioxidant capacity in golden pompano (Trachinotus ovatus) both in vivo and in vitro. In the in vivo study, two diets were formulated with or without astaxanthin supplementation (D1 and D2; 0 and 200 mg/kg) to feed fish for 6 weeks. In the in vitro study, cells from hepatopancreas of golden pompano were isolated and four treatments with or without astaxanthin and H 2 O 2 supplementation were applied (control group: without both astaxanthin and H 2 O 2 treated; H 2 O 2 group: just with H 2 O 2 treated; H 2 O 2 + AST group: with both astaxanthin and H 2 O 2 treated; AST group: just with AST treated). Results of the in vivo study showed that weight gain (WG) and special growth rate (SGR) significantly increased with astaxanthin supplemented (P < 0.05). Feed conversion ratio (FCR) of fish fed D2 diet was significantly lower than that of fish fed D1 diet (P < 0.05). Hepatic total antioxidant capacity (T-AOC) and the reduced glutathione (GSH) of golden pompano fed D2 diet were significant higher than those of fish fed D1 diet (P < 0.05). Superoxide dismutase (SOD) was significantly declined as astaxanthin was supplemented (P < 0.05). Results of the in vitro study showed that the cell viability of H 2 O 2 group was 52.37% compared to the control group, and it was significantly elevated to 84.18% by astaxanthin supplementation (H 2 O 2 + AST group) (P < 0.05). The total antioxidant capacity (T-AOC) and the reduced glutathione (GSH) of cell were significant decreased by oxidative stress from H 2 O 2 (P < 0.05), but it could be raised by astaxanthin supplementation (H 2 O 2 vs H 2 O 2 + AST), and the malondialdehyde (MDA) was significant higher in H 2 O 2 group (P < 0.05) and astaxanthin supplementation could alleviate the cells from lipid peroxidation injury. In conclusion, dietary astaxanthin supplementation can improve the growth performance of golden pompano. Moreover, astaxanthin can improve the golden pompano hepatic antioxidant capacity both in vivo and in vitro study by eliminating the reactive oxygen species.

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“…Astaxanthin and Antidiabetic Activity: Diabetes mellitus is strongly associated with oxidative stress, which can be a consequence of increased free radical production, reduced antioxidant defenses or both 48 . Oxidative stress induced by hyperglycemia possibly causes the dysfunction of pancreatic b-cells and various forms of tissue damage in patients with diabetes mellitus 49 .…”

Section: Astaxanthin As Powerful Antioxidantmentioning

confidence: 99%

Untitled

2012

IJPSR

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Astaxanthin, a member of the carotenoid family, is a dark-red pigment which is the main carotenoid found in the marine world of algae and aquatic animals. Astaxanthin, is present in many types of seafood, including salmon, trout, red sea bream, shrimp and lobster, as well as in birds such as flamingo and quail. Synthetic Astaxanthin dominates the world market but recent interest in natural sources of the pigment has increased substantially.

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In vivo astaxanthin treatment partially prevents antioxidant alterations in dental pulp from alloxan‐induced diabetic rats

Abstract: Diabetes altered the antioxidant system in dental pulp tissue; astaxanthin partially improved the diabetic complications.

Cited by 40 publications

References 48 publications

Potential health‐promoting effects of astaxanthin: A high‐value carotenoid mostly from microalgae

Potential health‐promoting effects of astaxanthin: A high‐value carotenoid mostly from microalgae

Effects of astaxanthin on antioxidant capacity of golden pompano (Trachinotus ovatus) in vivo and in vitro

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