<i>In vivo</i> bioactivity of herbal‐drug‐incorporated nanofibrous matrixes

Mary, Soloman Agnes; Dev, V. R. Giri

doi:10.1002/app.42178

Cited by 16 publications

(4 citation statements)

References 19 publications

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“…The PVA+SBA-15+curcumin composite nanofiber with an average contact angle of 48.2°±1.4 was highly hydrophilic compared to PVA and PVA+curcumin, which was due to the combination of PVA and SBA-15 [39,40] as both are hydrophilic in nature (table 4). Moreover, a moist wound is known to maintain both optimal wound temperature and reduced infection rate and scarring compared to dry wounds [41]. Thus, the synthesized nanofiber with hydrophilicity enables good potential for cell-biomaterial interaction and forms a suitable material for wound dressing.…”

Section: Contact Angle Measurementmentioning

confidence: 99%

Retracted: Design and fabrication of electrospun SBA-15-incorporated PVA with curcumin: a biomimetic nanoscaffold for skin tissue engineering

et al. 2020

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Fabricating and designing a scaffold is a complex and highly challenging process in the current scenario. The present study deals with the design and fabrication of electrospun Santa Barbara Amorphous (SBA)-15-incorporated polyvinyl alcohol (PVA) with curcumin, which can be used as a biomimetic nanoscaffold for skin tissue engineering. Curcumin was selected due to its effective anti-microbial and anti-inflammatory properties. SBA-15 was selected for its characteristic drug-carrying potential. Fourier transform infrared spectroscopy and x-ray diffraction characterizations of the fabricated nanofiber demonstrated the interaction of PVA, SBA-15 and curcumin. The scanning electron microscopy results depicted that the nanofiber was highly interconnected with a porous structure mimicking the extracellular matrix. The nanofibrous scaffold showed a higher percentage of cell migration, proliferation, cytocompatibility and biocompatibility with absence of cytotoxicity which was evidenced from the results of MTT assay, cell adhesion and live/dead assay using HaCaT cells. The results of the anti-bacterial test depicted that the synthesized nanofiber forms a potent material for skin wound-healing therapeutics. The in vitro drug release study performed over a period of 80 h revealed a sustained release pattern of curcumin from the SBA-15-incorporated PVA nanofiber. Finally, the in vivo results confirmed that SBA-15-incorporated PVA nanofiber with curcumin showed efficient wound-healing activities.

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Section: Contact Angle Measurementmentioning

confidence: 99%

Retracted: Design and fabrication of electrospun SBA-15-incorporated PVA with curcumin: a biomimetic nanoscaffold for skin tissue engineering

et al. 2020

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“…Conversely, CS_PEO and CS_AV_PEO layers presented WCA values of 75.58° ± 12.57° and 69.06° ± 3.78° which are characteristic of moderate hydrophilic materials. Such WCA values can be explained by the presence of natural polymers (CS and AV) that have functional groups like amides, esters, and hydroxyl groups which confer hydrophilic character to the bottom layer [ 81 , 82 ]. During the wound healing process, hydrophilic materials are able to provide moist environments, that enhance the healing process [ 83 ].…”

Section: Resultsmentioning

confidence: 99%

Electrospun Polycaprolactone/Aloe Vera_Chitosan Nanofibrous Asymmetric Membranes Aimed for Wound Healing Applications

et al. 2017

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Today, none of the wound dressings available on the market is fully capable of reproducing all the features of native skin. Herein, an asymmetric electrospun membrane was produced to mimic both layers of skin. It comprises a top dense layer (manufactured with polycaprolactone) that was designed to provide mechanical support to the wound and a bottom porous layer (composed of chitosan and Aloe Vera) aimed to improve the bactericidal activity of the membrane and ultimately the healing process. The results obtained revealed that the produced asymmetric membranes displayed a porosity, wettability, as well as mechanical properties similar to those presented by the native skin. Fibroblast cells were able to adhere, spread, and proliferate on the surface of the membranes and the intrinsic structure of the two layers of the membrane is capable of avoiding the invasion of microorganisms while conferring bioactive properties. Such data reveals the potential of these asymmetric membranes, in the near future, to be applied as wound dressings.

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“…The PVA + 3% MC sample showed a ZOI for S. aureus of 1.3 ± 0.3 mm, which was greater compared to the inhibition zones observed for PVA + 1% MC (0.6 ± 0.1 mm), PVA + 2% MC (0.9 ± 0.2 mm), and PVA (0.5 ± 0.08 mm). Similarly, the anti-bacterial activity described by Esath Natheer et al in 2012 [73] and Selvam et al in 2008 [22,23] for MC extract also reported the observation of a higher ZOI for a higher concentration of the tested pathogens. The inhibitory results for PVA, PVA + 1% MC, PVA + 2% MC, and PVA + 3% MC nanofibrous scaffolds for the gram-negative pathogen E. coli were 0.4 ± 0.07, 0.6 ± 0.1, 0.9 ± 0.2, and 1.3 ± 0.3 mm respectively.…”

Section: Anti-bacterial Assaymentioning

confidence: 52%

Design and fabrication of electrospun Morinda citrifolia-based nanofibrous scaffold as skin wound dressing material: in vitro and in silico analysis

Ekambaram

Sugumar

Swaminathan³

et al. 2021

Biomed. Mater.

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Wound healing is an urgent problem that impacts quality of life, and the need for biomaterials suitable for the treatment of skin wound healing disease is increasing annually. Innovative biomaterials and treatments for skin abrasions are being relentlessly researched and established in order to improve treatment efficacy. Here, we describe a novel electrospun polymeric nanofibrous scaffold enriched with pharmaceutical bioactive materials extracted from Morinda citrifolia (MC), which demonstrated efficient skin wound healing therapy due to its excellent human skin keratinocyte proliferation and adhesion in in vitro analysis. Surface morphological analysis was used to reveal the nano-architectural structure of the electrospun scaffolds. The fabricated nanofibers displayed good antibacterial efficacy by creating an inhibitory zone for the pathogenic microbes studied. MC supported active healing due to the presence of pharmaceuticals associated with wound healing, as revealed by the results of gas chromatography–mass spectrometry and the prediction of activity spectra for substances (PASS) analysis. Since MC is a multi-potential therapeutic herbal plant, it was found that the linoleic acid, olelic acid, and diethyl phthalate present in the extract supported the wound healing proteins glycogen-synthase-kinase-3-β-protein and Protein Data Bank—1Q5K with binding energies of −4.6, −5.2, and −5.9 kcal mol−1, as established by the results of in silico analysis. Thus, by being hydrophilic in nature, targeting wound proteins, increasing the proliferation and adhesion of keratinocytes and combating pathogens, the nanofibrous scaffolds endowed with MC extract proved to be an effective therapeutic material for skin wound dressing applications.

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In vivo bioactivity of herbal‐drug‐incorporated nanofibrous matrixes

Cited by 16 publications

References 19 publications

Retracted: Design and fabrication of electrospun SBA-15-incorporated PVA with curcumin: a biomimetic nanoscaffold for skin tissue engineering

Retracted: Design and fabrication of electrospun SBA-15-incorporated PVA with curcumin: a biomimetic nanoscaffold for skin tissue engineering

Electrospun Polycaprolactone/Aloe Vera_Chitosan Nanofibrous Asymmetric Membranes Aimed for Wound Healing Applications

Design and fabrication of electrospun Morinda citrifolia-based nanofibrous scaffold as skin wound dressing material: in vitro and in silico analysis

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