In vivo biocompatibility of three different chemical compositions of Ricinus communis polyurethane

Abstract

Alteration in the chemical composition of a biomaterial may be undertaken to improve its biological properties. The aim of this work was to evaluate the biocompatibility of three chemical compositions of Ricinus communis polyurethane (RCP): RCPp (pure RCP), RCP + CaCO(3), and RCP +Ca(3)(PO(4))(2). RCP cylinders were surgically implanted in rabbit femurs. After 8, 12, and 16 weeks, the femurs were removed, fixed, sectioned, ground, and stained by Stevenel's blue/Alizarin red S for light microscopy and histomorphometry. The osseointegration and osseoconductivity were calculated by means of image analysis and the data were submitted to the Kruskal-Wallis test followed by Dunn's test. Osseointegration was already completed after 8 weeks on RCP + Ca(3)(PO(4))(2) because similar values were found from week 8 to 16, whereas it showed a time-dependent increase on RCPp and RCP +CaCO(3). The osseointegration was greater on RCP + Ca(3)(PO(4))(2) in all periods when compared with RCPp, and after 8 and 12 weeks when compared with RCP + CaCO(3). None of the RCP samples presented osseoconductivity. The present results showed that RCP blended with calcium phosphate improved the biocompatibility by both enhancing and accelerating its osseointegration. Based on the absence of osseoconductivity, RCP was considered to be a bioinert material.

Biocompatibility and osteogenesis of the castor bean polymer doped with silica (SiO2) or barium titanate (BaTiO3) nanoparticles

“…Many studies 5,7,10 point out the advantages of using castor oil polymer as a framework for bone growth, however, castor oil polymer integrates itself to the receiving bone in a slower and more incomplete manner when compared to autogenous bone graft 15 , especially for not displaying specific biological traits.…”

“…Experimental studies have shown the applicability in vivo 5,6 and the benefits for castor oil polymer in vitro 7,8 , revealing the biocompatibility, osteointegration and, mainly, the diameter, conformation and intercommunication of the pores as the most important aspects to regulate vascular and cellular migration to the inside of these implants, allowing for bone neoformation.…”

Rigid and semi rigid polyurethane resins: A structural investigation using DMA, SAXS and Le Bail method

“…Since, in the late 1930s, Otto Bayer and co-workers discovered and patented the chemistry of polyurethanes, these materials have found an increasingly outstanding position among the most important organic polymers for intensive technological applications [1][2][3]. Polymerized urethane resins represent a product of chemical reaction between an isocyanate and a hydroxyl group [4][5][6].…”

Qualitative histologic evaluation of the tissue reaction to the Polyurethane resin (Ricinus communis based biopolymer) implantation assessed by light and scanning electron microscopy

“…This resin is commercially available with the brand name "COR -Composto Óleo de Rícino" [25] . Barros et al [26] evaluated biocompatibility of polyurethane resin (pure), the polyurethane resin with calcium carbonate and with calcium phosphate. The materials were made in cylindrical form and were randomly placed in defects created in rabbit femur.…”