<i>In vivo</i> decreased dopamine transporter uptake in corticobasal degeneration presenting with primary progressive aphasia without parkinsonism

Gil-Navarro, S.; Gelpí, Ellen; Lomeña, Francisco; Montagut, N.; Lladó, Albert; Molinuevo, José Luís; Sánchez‐Valle, Raquel

doi:10.1111/ene.12445

Cited by 1 publication

(1 citation statement)

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“…However, we also know that 123 I FP-CIT SPECT semi-quantitative SPECT detects preclinical bilateral dopaminergic deficit in early Parkinson's disease with unilateral symptoms [39], so this distinction solely on the basis of imaging is not without a risk of misdiagnosis. In vivo decreased dopamine transporter uptake in corticobasal degeneration presenting with primary progressive aphasia without parkinsonism has been demonstrated [40]. However, in some instances, normal 123 I FP-CIT SPECT is seen in neuropathologically confirmed corticobasal degeneration [41•]; so normal 123 I FP-CIT SPECT does not necessarily rule out CBGD.…”

Section: Fp-cit Spect Imaging In Other Dementiasmentioning

confidence: 99%

Overview of Dopamine Transporter Imaging in Parkinson’s Disease, Dementia with Lewy Bodies and Other Dementias

Malek

Grosset

2015

Curr Geri Rep

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123 I FP-CIT is a radiotracer that is used in conjunction with single photon emission computed tomography (SPECT) scanning to detect dopaminergic neuron presynaptic terminal degeneration, in the striatum (caudate nucleus and putamen) of patients with Parkinson's disease (PD) and dementia with Lewy bodies (DLB), showing a reduced uptake of this ligand by the dopamine transporters (DaT). This is a licensed diagnostic test in Europe (as DaTSCAN) and in the USA (as DaTscan). Recent work on functional imaging in PD and DLB largely uses the FP-CIT SPECT approach, and this is the focus of our paper, whilst noting that other ligands (e.g. beta-CIT) and imaging techniques such as positron emission tomography (PET) have been used in similar settings.

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Section: Fp-cit Spect Imaging In Other Dementiasmentioning

confidence: 99%