<i>In Vivo</i> Detection of Cerebral Cortical Microinfarcts with High-Resolution 7T MRI

Veluw, Susanne J. van; Zwanenburg, Jaco J.M.; Engelen-Lee, Joo-Yeon; Spliet, Wim G.M.; Hendrikse, Jeroen; Luijten, Peter R.; Biessels, Geert Jan

doi:10.1038/jcbfm.2012.196

Cited by 185 publications

(230 citation statements)

References 31 publications

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“…This is in line with results from our previous MRI-histopathology study on 7-tesla MRI. 5 Apparently, these MRI features are specific for intracortical CMIs. When a chronic gliotic CMI is accompanied by cavitation or hemorrhagic components, this can be discerned on MRI.…”

Section: Discussionmentioning

confidence: 99%

“…Despite lower signal-to-noise ratio and resolution, it seems feasible to recognize chronic gliotic CMIs on 3-tesla MRI as well. 5,[26][27][28] Hemorrhagic CMIs cannot currently be distinguished from primary hemorrhages, both will be regarded as cerebral microbleeds on in vivo MRI. Juxtacortical hyperintense lesions should best be discarded.…”

Section: Discussionmentioning

confidence: 99%

“…We screened MR images of subjects with known cortical CMIs from previous 7-tesla studies. [5][6][7][8] These studies comprised MRI scans of subjects with early Alzheimer's disease, intracerebral hemorrhage, type 2 diabetes, and controls. Chronic gliotic CMIs with and without cavitation could be identified on in vivo 7-tesla MRI ( Figure 6).…”

Section: Histopathologic Evaluation Of Magnetic Resonance-negative Comentioning

confidence: 99%

“…According to that definition, cortical CMIs are intracortical lesions, hyperintense on fluid-attenuated inversion recovery (FLAIR) and on T2, hypointense on T1, ⩽ 3 mm in size, and distinct from perivascular spaces (PVSs). 5 In this initial study, we purposefully devised a definition that was likely to be specific for CMIs, because our intention was to show feasibility of in vivo CMI detection. It could well be, however, that this definition misses certain cortical CMIs that are visible on MRI, but have different MRI characteristics.…”

Section: Introductionmentioning

confidence: 99%

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The Spectrum of MR Detectable Cortical Microinfarcts: A Classification Study with 7-Tesla Postmortem MRI and Histopathology

Veluw

Zwanenburg

Rozemüller

et al. 2015

J Cereb Blood Flow Metab

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Cerebral microinfarcts (CMIs) are common neuropathologic findings in aging and dementia. We explored the spectrum of cortical CMIs that can be visualized with 7T magnetic resonance imaging (MRI). Thirty-three coronal brain slices of 11 individuals with neuropathologically confirmed dementia were subjected to a high-resolution postmortem 7T MRI protocol. First, we identified all visible small (⩽5 mm) intracortical and juxtacortical lesions on postmortem MRI. Lesions were classified as CMI or nonCMI based on histology, and their MR features were recorded. Thirty lesions were identified on the initial MRI evaluation, of which twenty-three could be matched with histology. Histopathology classified 12 lesions as CMIs, all of which were located intracortically. On the basis of their MR features, they could be classified as chronic gliotic CMIs-with or without cavitation or hemorrhagic components-and acute CMIs. Eleven MRI identified lesions were not of ischemic nature and most commonly enlarged or atypically shaped perivascular spaces. Their MRI features were similar to gliotic CMIs with or without cavitation, but these 'CMI mimics' were always located juxtacortically. 7T postmortem MRI distinguishes different histopathologic types of cortical CMIs, with distinctive MR characteristics. On the basis of our findings, we propose in vivo rating criteria for the detection of intracortical CMIs.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Histopathologic Evaluation Of Magnetic Resonance-negative Comentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The Spectrum of MR Detectable Cortical Microinfarcts: A Classification Study with 7-Tesla Postmortem MRI and Histopathology

Veluw

Zwanenburg

Rozemüller

et al. 2015

J Cereb Blood Flow Metab

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“…Weiterhin konnte in einer vergleichenden Studien nachgewiesen werden, dass die UHF-MRT deutlich mehr kortikale Mikroinfarkte detektiert als die 3-T-MRT [118]. …”

Section: Mrt Im Vergleich Zu 3 T Eine Deutlich Detailliertere Darstelunclassified

Ultrahochfeld-MRT im Kontext neurologischer Erkrankungen

et al. 2014

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Association Between Subclinical Cardiac Biomarkers and Clinically Manifest Cardiac Diseases With Cortical Cerebral Microinfarcts

et al. 2017

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IMPORTANCE Subclinical and clinical cardiac diseases have been previously linked to magnetic resonance imaging (MRI) manifestations of cerebrovascular disease, such as lacunes and white matter hyperintensities, as well as dementia. Cortical cerebral microinfarcts (CMIs), a novel MRI marker of cerebral vascular disease, have not been studied, to date, in relation to subclinical and clinical cardiac diseases.OBJECTIVE To examine the association of blood biomarkers of subclinical cardiac disease and clinically manifest cardiac diseases with CMIs graded on 3-T MRI in a memory clinic population. DESIGN, SETTING, AND PARTICIPANTSThis baseline cross-sectional analysis of a cohort study performed from August 12, 2010, to July 28, 2015, included 464 memory clinic participants. All participants underwent collection of blood samples, neuropsychological assessment, and 3-T MRI.EXPOSURES N-terminal pro-brain natriuretic peptide (NT-proBNP) and high-sensitivity cardiac troponin T (hs-cTnT) concentrations were measured by electrochemiluminescence immunoassays. Cardiac disease was defined as a history of atrial fibrillation, ischemic heart diseases, or congestive heart failure. MAIN OUTCOMES AND MEASURESThe CMIs were graded according to a previously validated protocol.RESULTS Of 464 participants, 124 had insufficient blood plasma samples and 97 had no CMI grading (none, incomplete, or ungradable MRI), leaving a sample size of 243 for final analysis (mean [SD] age, 72.8 [9.1] years; 116 men [42.9%]). Seventy participants (28.8%) had cortical CMIs (median, 1; range, 0-43). Compared with participants with no CMIs, those with CMIs had a significantly higher prevalence of atrial fibrillation (rate ratio [RR], 1.62; 95% CI, 1.20-21.8), ischemic heart disease (RR, 4.31; 95% CI,, and congestive heart failure (RR, 2.05; 95% CI, 1.29-3.25). Significantly higher levels of NT-proBNP (RR, 3.16; 95% CI, 2.33-4.27) and hs-cTnT (RR, 2.17; 95% CI, 1.00-4.74) were found in participants with CMIs. In multivariate models adjusted for demographics and vascular risk factors, higher levels of 3.19; 95% CI,) and hs-cTnT (RR, 4.86; 95% CI, 3.03-7.08) were associated with CMIs. These associations persisted even after excluding patients with clinically manifest cardiac disease.CONCLUSIONS AND RELEVANCE This study found that biomarkers of subclinical cardiac disease and clinically manifest cardiac diseases were associated with CMIs on 3-T MRI in patients attending a memory clinic, suggesting that cardiac disease may contribute to the development of CMIs. Hence, cardiac dysfunction should be targeted as a potentially modifiable factor to prevent CMI-related brain injury.

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In Vivo Detection of Cerebral Cortical Microinfarcts with High-Resolution 7T MRI

Cited by 185 publications

References 31 publications

The Spectrum of MR Detectable Cortical Microinfarcts: A Classification Study with 7-Tesla Postmortem MRI and Histopathology

The Spectrum of MR Detectable Cortical Microinfarcts: A Classification Study with 7-Tesla Postmortem MRI and Histopathology

Ultrahochfeld-MRT im Kontext neurologischer Erkrankungen

Association Between Subclinical Cardiac Biomarkers and Clinically Manifest Cardiac Diseases With Cortical Cerebral Microinfarcts

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