In vivo evaluation of resorbable bone graft substitutes in beagles: Histological properties

Abstract

Calcium phosphate cement (CPC) is a promising material for use in minimally invasive surgery for bone defect repairs due to its bone-like apatitic final setting product, biocompatibility, bioactivity, self-setting characteristics, low setting temperature, adequate stiffness, and easy shaping into complicated geometrics. However, even though CPC is stable in vivo, the resorption rate of this bone cement is very slow and its long setting time poses difficulties for clinical use. Calcium sulfate dehydrate (CSD) has been used as a filler material and/or as a replacement for cancellous bone grafts due to its biocompatibility. However, it is resorbed too quickly to be optimal for bone regeneration. This study examines the invivo response of a hydroxyapatite (HA), [apatitic phase (AP)]/calcium sulfate (CSD) composite using different ratios in the mandibular premolar sockets of beagles. The HA (AP)/CSD composite materials were prepared in the ratios of 30/70, 50/50, and 70/30 and then implanted into the mandibular premolar sockets for terms of 5 and 10 weeks. The control socket was left empty. The study shows better new bone morphology and more new bone area in the histological and the histomorphometric study of the HA (AP)/CSD in the 50/50 ratio.

Effects of adding resorbable chitosan microspheres to calcium phosphate cements for bone regeneration

“…Thus, new bone was directly connected with the material. When bone apatite was in direct contact with apatite on the surface of the chitosan microsphere/CPC material, chemical bonds formed between the two and were closely interfaced [45,46]. However, chitosan microspheres of large particle size degraded slowly and occupied the space of new bone formation.…”

The impact of surface roughness and permeability in hydroxyapatite bone regeneration membranes

“…Hydroxyapatite is the main mineral matrix component of bone and by its bone‐like composition and structure, it has been suggested to be excellently accepted by bone tissue (Posner ,b; van Blitterswijk & Grote ) with slow or no resorption rate (Shih et al. ). The concept of space making with the use of hydroxyapatite has been described in sinus augmentation procedures.…”

Human periosteum cell osteogenic differentiation enhanced by ionic silicon release from porous amorphous silica fibrous scaffolds

“…Additionally, porous scaffolds made from these materials facilitate mineralized tissue ingress [10–12]. However, these materials degrade too slowly and it is difficult for the bone to completely resorb them [13, 14]. Bioactive glasses have also been used in bone defect filling applications.…”

“…[10][11][12] However, these materials degrade too slowly and it is difficult for the bone to completely resorb them. 13,14 Bioactive glasses have also been used in bone defect filling applications. They are FDA approved and degrade more rapidly than Ca-P based scaffolds.…”