<i>In vivo</i> magnetic nanoparticle hyperthermia: a review on preclinical studies, low-field nano-heaters, noninvasive thermometry and computer simulations for treatment planning

Rodrigues, Harley F; Capistrano, Gustavo; Bakuzis, Andris F.

doi:10.1080/02656736.2020.1800831

Cited by 83 publications

(81 citation statements)

References 184 publications

(280 reference statements)

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“…However, rather than adopting a general or macroscopic view of this issue, we shall focus on the cellular and subcellular effects of this treatment. There are many in vitro and in vivo studies that have correlated MNPs and AMF therapies with extended life expectancy or tumour regression [ 131 ], although the biochemical mechanisms responsible for such improvements remain unclear. Depending on the magnetic features of the MNPs, and on the AMF amplitude and frequency, the MNPs can transform the energy of the magnetic field into heat or mechanical effects ( Figure 2 c, d, e).…”

Section: The Biological Effects Of the Application Of Afm To Cells Loaded With Mnps: Is It Always Hyperthermia?mentioning

confidence: 99%

Understanding MNPs Behaviour in Response to AMF in Biological Milieus and the Effects at the Cellular Level: Implications for a Rational Design That Drives Magnetic Hyperthermia Therapy toward Clinical Implementation

Egea-Benavente

Ovejero

Morales

et al. 2021

Cancers

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Hyperthermia has emerged as a promising alternative to conventional cancer therapies and in fact, traditional hyperthermia is now commonly used in combination with chemotherapy or surgery during cancer treatment. Nevertheless, non-specific application of hyperthermia generates various undesirable side-effects, such that nano-magnetic hyperthermia has arisen a possible solution to this problem. This technique to induce hyperthermia is based on the intrinsic capacity of magnetic nanoparticles to accumulate in a given target area and to respond to alternating magnetic fields (AMFs) by releasing heat, based on different principles of physics. Unfortunately, the clinical implementation of nano-magnetic hyperthermia has not been fluid and few clinical trials have been carried out. In this review, we want to demonstrate the need for more systematic and basic research in this area, as many of the sub-cellular and molecular mechanisms associated with this approach remain unclear. As such, we shall consider here the biological effects that occur and why this theoretically well-designed nano-system fails in physiological conditions. Moreover, we will offer some guidelines that may help establish successful strategies through the rational design of magnetic nanoparticles for magnetic hyperthermia.

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Section: The Biological Effects Of the Application Of Afm To Cells Loaded With Mnps: Is It Always Hyperthermia?mentioning

confidence: 99%

Understanding MNPs Behaviour in Response to AMF in Biological Milieus and the Effects at the Cellular Level: Implications for a Rational Design That Drives Magnetic Hyperthermia Therapy toward Clinical Implementation

Egea-Benavente

Ovejero

Morales

et al. 2021

Cancers

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“…4 In silico experiments are performed to estimate the Specific Adsorption Rate (SAR) and temperature increase under critical conditions, to provide safety advise for preclinical trials, sometime performed without fulfilling the Hergt-Dutz limit. 5 The results obtained on a 28 g weight mouse 3…”

Section: Resultsmentioning

confidence: 99%

In silico experiments as a tool to reduce preclinical tests of magnetic hyperthermia

Vicentini¹,

Vassallo

Ferrero

et al. 2021

Biomed Sci Eng

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In silico models can be useful tools to guide preclinical tests of magnetic hyperthermia, which employs Magnetic Nanoparticles (MNPs) excited by AC magnetic fields, as heat mediators for cancer cure. We virtually reproduce the heating process induced by magnetic hyperthermia in murine models, as a function of field applicator features, properties and size of target tissue, MNP dose and animal size.

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“…The proposed system successfully localized MNPs, provided real-time 2D temperature maps during MH, and qualitatively predicted the temperature distribution in MNP-laden regions. Because SPIONs are used in MMUS and tissues have temperature-dependent elastic properties, MMUS can also be used for thermometry during MH 147 . Various electromagnetic-acoustic techniques, such as magnetomotive photoacoustic imaging (MMPA), have also been proposed for theranostic applications.…”

Section: Magnetoacoustic Imagingmentioning

confidence: 99%

Magnetic mediators for ultrasound theranostics

Józefczak¹,

Kaczmarek²,

Bielas³

2021

Theranostics

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In vivo magnetic nanoparticle hyperthermia: a review on preclinical studies, low-field nano-heaters, noninvasive thermometry and computer simulations for treatment planning

Cited by 83 publications

References 184 publications

Understanding MNPs Behaviour in Response to AMF in Biological Milieus and the Effects at the Cellular Level: Implications for a Rational Design That Drives Magnetic Hyperthermia Therapy toward Clinical Implementation

Understanding MNPs Behaviour in Response to AMF in Biological Milieus and the Effects at the Cellular Level: Implications for a Rational Design That Drives Magnetic Hyperthermia Therapy toward Clinical Implementation

In silico experiments as a tool to reduce preclinical tests of magnetic hyperthermia

Magnetic mediators for ultrasound theranostics

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