<i>In vivo</i> measurement of the surface energy of human fingernail plates

Murdan, Sudaxshina; Poojary, C.; Patel, Dhrumil; Fernandes, João Filipe; Haman, Arthur C.; Saundh, P. S.; Sheikh, Z.

doi:10.1111/j.1468-2494.2012.00711.x

Cited by 16 publications

(4 citation statements)

References 38 publications

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“…It was not practical to use human nailplates for these tests due to their small size and scarcity, and therefore models -high density polyethylene (HDPE) and glass e were used. HDPE was used as its surface energy (35 mJ/m 2 ) [20] is similar to that of the nail plate (34.1 ± 5.5 mJ/m 2 [21], surface energy being known to influence adhesion [22]. Glass was used as it is a commonly used substrate to test adhesion of paints and lacquers.…”

Section: Introductionmentioning

confidence: 99%

To what extent do in vitro tests correctly predict the in vivo residence of nail lacquers on the nail plate?

Murdan¹,

Kerai²,

Hossin³

2015

Journal of Drug Delivery Science and Technology

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In vitro-in vivo correlations AdhesionIn vivo residence a b s t r a c t Pharmaceutical nail lacquers are used to topically treat nail fungal infections. The film's residence on the nail is an important factor, and in the laboratory, rapid in vitro adhesion and water resistance tests are often used to indicate their likely in vivo residence. However, the predictivity of such in vitro tests is unknown. The aim of this work was thus to determine whether, and to what extent, such in vitro tests can correctly predict the in vivo fate of nail lacquers. The in vivo residence of four commercially available nail lacquers (three pharmaceutical and one cosmetic) was determined in 16 volunteers. In vitro, the films' resistance to water, and their adhesion to a model nail plate was measured, and in vitro-in vivo correlations were explored. It was found that the in vitro films' resistance to water correctly predicted the in vivo residence of lacquers, while the adhesion tests did not.

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Section: Introductionmentioning

confidence: 99%

To what extent do in vitro tests correctly predict the in vivo residence of nail lacquers on the nail plate?

Murdan¹,

Kerai²,

Hossin³

2015

Journal of Drug Delivery Science and Technology

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“…In vivo ungual adhesion of patches showed that, although the patch did not remain adhered at 100% throughout the 2-week study, the patches did adhere to nail plates for several days, as we had previously predicted (Rizi, Mohammed et al 2018), based on their lower surface energies (30 mJ/m 2 ) compared to that of the human nail plate (34.1 ± 5.5 mJ/m 2 ; (Murdan, Poojary et al 2012), reflecting the need for the same or lower surface energy of the adhesive compared to that of the substrate for good intrinsic adhesion, (Venkatraman and Gale 1998).…”

Section: Anti-fungal Efficacy Of Patches Applied To Nail Platementioning

confidence: 53%

A drug-in-adhesive anti-onychomycotic nail patch: Influence of drug and adhesive nature on drug release, ungual permeation, in vivo residence in human and anti-fungal efficacy

Rizi¹,

Xu²,

Begum³

et al. 2022

International Journal of Pharmaceutics

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“…c) and the mechanical effect of the tool (nail file or nail drill machine) used to prepare the surface of the nail plate (Fig. e,f) …”

Section: Resultsmentioning

confidence: 99%

Evaluation of structural damage and pH of nail plates of hands after applying different methods of decorating

2018

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Background The purpose of this study was to evaluate the effect of nail polish, gel polish hybrid, gel nail, and acrylic nail powder and the removal of these formulas on the nail plates properties, particularly the influence of different coatings on morphology and pH.Methods The morphology and structure of nail plates were analyzed with use of scanning electron microscopy. The pH values of the nail plates of hands were measured using the system Courage & Khazaka.Results The analysis of morphology and structure of the surface of nail plates showed distinct changes caused by decorative coatings. The most common ones include fragility and splitting of the nails. The pH value measured in the whole group ranged from 5.21 to 7.00. ConclusionsThe methods used to prepare nails for decoration and all methods of removing the applied preparations damage the healthy nail plates. The most common changes are brittleness and nail splitting. The nail polish remover causes less damage than acetone, and the use of a nail drill machine and nail file causes the greatest destruction of nail plates. The biggest effect on the pH change has the gel polish hybrid, gel nail, and acrylic nail powder, causing the pH value of nail plates to rise above 6.0, whereas after the application of the nail polish, the pH of the plates was on average 5.8 which is closest to the normal value, assumed as physiological.

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In vivo measurement of the surface energy of human fingernail plates

Cited by 16 publications

References 38 publications

To what extent do in vitro tests correctly predict the in vivo residence of nail lacquers on the nail plate?

To what extent do in vitro tests correctly predict the in vivo residence of nail lacquers on the nail plate?

A drug-in-adhesive anti-onychomycotic nail patch: Influence of drug and adhesive nature on drug release, ungual permeation, in vivo residence in human and anti-fungal efficacy

Evaluation of structural damage and pH of nail plates of hands after applying different methods of decorating

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