<i>In vivo</i> performance of gold nanoparticle-loaded absorbable inferior vena cava filters in a swine model

Huang, Steven Y.; Damasco, Jossana A.; Tian, Li; Lu, Linfeng; Perez, Joy Vanessa D.; Dixon, Kathleen; Williams, Madison H.; Jacobsen, Megan C.; Dria, Stephen; Eggers, M.; Melancon, Adam David; Layman, Rick R.; Whitley, Elizabeth M.; Melancon, Marites P.

doi:10.1039/d0bm00414f

Cited by 19 publications

(20 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The size and morphology of the BiNPs were determined using transmission electron microscopy (JEOL USA, Inc., Peabody, MA), Absorbable IVCFs based on poly(p-dioxanone) sutures (Adient Medical, Pearland, TX) were manufactured and infused with BiNPs using a method similar to that described previously. 4,18,[32][33][34] Scanning electron microscopy with energy-dispersive x-ray analysis (Nova NanoSEM microscope; FEI, Hillsboro, OR) was performed to determine the morphology and presence of bismuth on the surface of the BiNP-IVCF.…”

Section: B Part Ii: Application Of Optimized Analysis Methods On Bimentioning

confidence: 99%

“…The BiNP‐IVCF was deployed under fluoroscopic guidance in an adult domestic pig (weight: 43 kg) as previously described 4,18,32 . Computed tomography imaging of the pig was performed 1 week after deployment of the BiNP‐IVCF with precontrast and postcontrast imaging.…”

Section: Methodsmentioning

confidence: 99%

“…The BiNP-IVCF was deployed under fluoroscopic guidance in an adult domestic pig (weight: 43 kg) as previously described. 4,18,32 Computed tomography imaging of the pig was performed 1 week after deployment of the BiNP-IVCF with precontrast and postcontrast imaging. Postcontrast imaging was performed with iothalamate meglumine (Conray) injection (USP 60%, 252 mg/mL) at a dose of 2 mL/kg in the arterial phase.…”

Section: B5 Deployment and Imaging Of The Binp-ivcf In Vivomentioning

confidence: 99%

“…Researchers showed the degradation of collagen conjugated with gold nanoparticles (AuNP) to be strongly correlated with a decrease in CT number during long‐term monitoring 17 . Our group has also demonstrated the use of clinical CT imaging in long‐term monitoring of AuNP‐infused IVCF in pigs 18 . However, due to the high cost of gold, alternative high atomic number (high‐Z) contrast agents should also be investigated.…”

Section: Introductionmentioning

confidence: 96%

“…17 Our group has also demonstrated the use of clinical CT imaging in long-term monitoring of AuNP-infused IVCF in pigs. 18 However, due to the high cost of gold, alternative high atomic number (high-Z) contrast agents should also be investigated. Additionally, use of high-Z nanoparticles incorporated within a medical device would be advantageous because the nanoparticles can potentially be differentiated from iodinated agents.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Optimization of the differentiation and quantification of high‐Z nanoparticles incorporated in medical devices for CT‐guided interventions

et al. 2020

Self Cite

View full text Add to dashboard Cite

Purpose Material differentiation has been made possible using dual‐energy computed tomography (DECT), in which the unique, energy‐dependent attenuating characteristics of materials can provide new diagnostic information. One promising application is the clinical integration of biodegradable polymers as temporary implantable medical devices impregnated with high‐atomic number (high‐Z) materials. The purpose of this study was to explore the incorporation of high atomic number (high‐Z) contrast materials in a bioresorbable inferior vena cava filter for advanced CT‐based monitoring of its location and differentiating from surrounding materials. Materials and methods Imaging optimization and calibration studies were performed using a body phantom. The dual‐energy CT (DECT) ratios for iron, zirconium, barium, gadolinium, ytterbium, tantalum, tungsten, gold, and bismuth were generated for peak kilovoltage combinations of 80/150Sn, 90/150Sn, and 100/150Sn kVp in dual‐source CT via linear regression of the CT numbers at low and high energies. A secondary calibration of the material map to the nominal material concentration was generated to correct for use of materials other than iodine. CT number was calibrated to the material concentration based on single‐energy CT (SECT) with additional filtration (150Sn kVp). These quantification methods were applied to monitoring of biodegradable inferior vena cava filters (IVCFs) made of braided poly(p‐dioxanone) sutures infused with ultrasmall bismuth nanoparticles (BiNPs) implanted in an adult domestic pig. Results Qualitative material differentiation was optimal for high‐Z (>73) contrast agents in DECT. However, quantification became nonlinear and inaccurate as the K‐edge of the material increased. Using the high‐energy (150Sn kVp) data component as a SECT scan, the linearity of quantification curves was maintained with lower limits of detection than with DECT. Among the materials tested, bismuth had optimal differentiation from iodine in DECT while maintaining increased contrast in high‐energy SECT for quantification (11.5% error). Coating the IVCF with BiNPs resulted in markedly greater radiopacity (maximum CT number, 2028 HU) than that of an uncoated IVCF (maximum CT number, 127 HU). Using DECT imaging and processing, the BiNP‐IVCF could be clearly differentiated from iodine contrast injected into the inferior vena cava of the pig. Conclusions These findings may improve widespread integration of medical devices incorporated with high‐Z materials into the clinic, where technical success, possible complications, and device integrity can be assessed intraoperatively and postoperatively via DECT imaging.

show abstract

Section: B Part Ii: Application Of Optimized Analysis Methods On Bimentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: B5 Deployment and Imaging Of The Binp-ivcf In Vivomentioning

confidence: 99%

Section: Introductionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Optimization of the differentiation and quantification of high‐Z nanoparticles incorporated in medical devices for CT‐guided interventions

et al. 2020

Self Cite

View full text Add to dashboard Cite

show abstract

Recent Progress in Advanced Hydrogel‐Based Embolic Agents: From Rational Design Strategies to Improved Endovascular Embolization

Ullah

et al. 2023

Adv Healthcare Materials

View full text Add to dashboard Cite

Transcatheter arterial embolization, a minimally invasive treatment to deliberately occlude the blood vessels, has become a safe and effective procedure for the management of vascular diseases and benign/malignant tumors. Particularly, hydrogel‐based embolic agents have garnered much attention because of their potential to address some of the limitations of clinically used embolic agents and can be rationally designed to impart more favorable characteristics or functions. In this review, the recent progress toward the development of polymer‐based hydrogels for effective endovascular embolization, including the in situ gelling hydrogels mediated by physically or chemically crosslinking, imageable hydrogels for intraprocedural and postprocedural feedback, use of hydrogels as the drug depot for local delivery of therapeutic drugs, hemostatic hydrogels inducing extrinsic or intrinsic coagulation of blood, stimuli‐responsive shape memory hydrogels as the smart embolization devices, and hydrogels incorporating external‐stimuli functional materials for multidisciplinary therapy, is systemically summarized. Moreover, the potential considerations of hydrogel‐based embolic agents confronted in therapeutic embolization are pointed out. Finally, the perspectives for the development of more effective embolic hydrogels are also highlighted.

show abstract

In vitro and in vivo evaluation of degradability and biocompatibility of poly(p‐dioxanone) hemostatic clips for laparoscopic surgery

Zheng

Peng

Wang³

et al. 2021

J of Applied Polymer Sci

View full text Add to dashboard Cite

For the clinical application of biodegradable hemostatic surgical clips in laparoscopic surgery, it is necessary to determine their degradability and biocompatibility. Herein, in vitro and in vivo studies were undertaken to evaluate the degradability and biocompatibility of bioabsorbable clips made of poly(p‐dioxanone). Changes in weight loss, pull‐off force, differential scanning calorimetry (DSC), and scanning electron microscopy (SEM) of the poly(p‐dioxanone) clips were determined after they were degraded in deionized water and phosphate buffer saline for the in vitro experiment and in laparoscopic models of bile duct ligation(BDL) and right gastroepiploic artery ligation(GEAL) using New Zealand white rabbits for the in vivo experiment. Changes in weight loss and pull‐off force were greater in the in vivo experiment than the in vitro experiment. DSC showed the greatest variation in the degree of crystallinity of the clips degraded in deionized water. Stark differences in SEM were observed after 4 weeks of degradation both in vitro and in vivo. Furthermore, the cytocompatibility of the clips was considered satisfactory because the L929 cells could adhere to the clips and proliferate adequately in the presence of the clip extract. Biocompatibility was inferred based on the histological analysis of BDL and GEAL, no significant inflammatory responses were observed after 4 weeks of ligation.

show abstract

In vivo performance of gold nanoparticle-loaded absorbable inferior vena cava filters in a swine model

Abstract: AuNP infusion significantly improved absorbable IVCF's visualization in CT for device monitoring and clot trapping ability with no adverse effects.

Cited by 19 publications

References 46 publications

Optimization of the differentiation and quantification of high‐Z nanoparticles incorporated in medical devices for CT‐guided interventions

Optimization of the differentiation and quantification of high‐Z nanoparticles incorporated in medical devices for CT‐guided interventions

Recent Progress in Advanced Hydrogel‐Based Embolic Agents: From Rational Design Strategies to Improved Endovascular Embolization

In vitro and in vivo evaluation of degradability and biocompatibility of poly(p‐dioxanone) hemostatic clips for laparoscopic surgery

Contact Info

Product

Resources

About