In vivoregulation of an endogenously-tagged protein by a light-regulated kinase
Mengjing Bao,
Katarzyna Lepeta,
Gustavo Aguilar
et al.
Abstract:Post-translational modifications (PTMs) are indispensable modulators of protein activity. Most cellular behaviours, from cell division to cytoskeletal organization, are controlled by PTMs, their miss-regulation being associated with a plethora of human diseases. Traditionally, the role of PTMs has been studied employing biochemical techniques. However, these approaches fall short when studying PTM dynamics in vivo. In recent years, functionalized protein binders have allowed the post-translational modification… Show more
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