<i>In vivo</i> senescence imaging nanoprobe targets the associated reactive oxygen species

Lee, Seung Koo; Han, Myung Shin; Tung, Ching-Hsuan

doi:10.1039/d3nr04083f

Nanoscale

2024

DOI: 10.1039/d3nr04083f

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In vivo senescence imaging nanoprobe targets the associated reactive oxygen species

Seung Koo Lee,

Myung Shin Han,

Ching-Hsuan Tung

Abstract: A novel nanoprobe, named D3, has been designed to detect the highly elevated levels of reactive oxygen species (ROS) in senescent cells. Conversely, the non-senescent cells whose ROS level is too low to activate D3 signal remain optically silent.

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Recent Developments in Small-Molecule Fluorescent Probes for Cellular Senescence

Park,

Lee,

Park

2024

Chemosensors

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Cellular senescence is a recently emerged research topic in modern biology. Often described as a double-edged sword, it encompasses numerous essential biological processes, including beneficial effects such as wound healing and embryonic development, as well as detrimental contributions to chronic inflammation and tumor development. Consequently, there is an increasing need to unravel the intricate networks of senescence and develop reliable detection methods to distinguish it from related phenomena. To address these challenges, a variety of detection methods have been developed. In particular, small-molecule fluorescent probes offer distinct advantages such as suitability for real-time live cell monitoring and in vivo imaging, superior tunable properties, and versatile applications. In this review, we explored recent advancements in the development of small-molecule fluorescent probes toward monitoring cellular senescence by targeting various senescence-related biological phenomena. These phenomena include the upregulation of senescence-associated enzymes, perturbation of the subcellular environment, and increased endogenous ROS levels. Moreover, multi-senescence biomarker-targeting approaches are also discussed to improve their sensitivities and specificities for the detection of cellular senescence. With recent advances in senescence probe development, current challenges in this field are also discussed to facilitate further progress.

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Recent Developments in Small-Molecule Fluorescent Probes for Cellular Senescence

Park,

Lee,

Park

2024

Chemosensors

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show abstract

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In vivo senescence imaging nanoprobe targets the associated reactive oxygen species

Abstract: A novel nanoprobe, named D3, has been designed to detect the highly elevated levels of reactive oxygen species (ROS) in senescent cells. Conversely, the non-senescent cells whose ROS level is too low to activate D3 signal remain optically silent.

Cited by 1 publication

References 47 publications

Recent Developments in Small-Molecule Fluorescent Probes for Cellular Senescence

Recent Developments in Small-Molecule Fluorescent Probes for Cellular Senescence

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