<i>In vivo</i> serotonin 1A receptor hippocampal binding potential in depression and reported childhood adversity

Bartlett, Elizabeth; Yttredahl, Ashley; Boldrini, Maura; Tyrer, Andrea; Hill, Kathryn; Ananth, Mala; Milak, Matthew S.; Oquendo, María A.; Mann, J. John; DeLorenzo, Christine; Parsey, Ramin V.

doi:10.1192/j.eurpsy.2023.4

Cited by 8 publications

(1 citation statement)

References 85 publications

(174 reference statements)

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“…Conversely, a review by Shrestha et al [78] reported that among the eight studies they reviewed on 5-HT1A expression in the brains of patients with MDD, four demonstrated a decrease in 5-HT1A receptor density, two showed no change, and only two indicated an increase in 5-HT1A receptor density. Furthermore, Bartlett et al [79] found no correlation between the severity of a depressive episode and an increase in 5-HT1AR binding potential. Another study indicated a decrease in the expression of 5-HT1A in the reserpine model of depression in rats [80].…”

Section: Receptormentioning

confidence: 98%

Functional Dimerization of Serotonin Receptors: Role in Health and Depressive Disorders

Mitroshina,

Marasanova,

Vedunova

2023

IJMS

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Understanding the neurobiological underpinnings of depressive disorder constitutes a pressing challenge in the fields of psychiatry and neurobiology. Depression represents one of the most prevalent forms of mental and behavioral disorders globally. Alterations in dimerization capacity can influence the functional characteristics of serotonin receptors and may constitute a contributing factor to the onset of depressive disorders. The objective of this review is to consolidate the current understanding of interactions within the 5-HT receptor family and between 5-HT receptors and members of other receptor families. Furthermore, it aims to elucidate the role of such complexes in depressive disorders and delineate the mechanisms through which antidepressants exert their effects.

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Section: Receptormentioning

confidence: 98%

Functional Dimerization of Serotonin Receptors: Role in Health and Depressive Disorders

Mitroshina,

Marasanova,

Vedunova

2023

IJMS

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Unraveling the Pathogenesis of Post‐Stroke Depression in a Hemorrhagic Mouse Model through Frontal Lobe Circuitry and JAK‐STAT Signaling

Wu,

Deng,

et al. 2024

Advanced Science

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Post‐stroke depression is a common complication that imposes significant burdens and challenges on patients. The occurrence of depression is often associated with frontal lobe hemorrhage, however, current understanding of the underlying mechanisms remains limited. Here, the pathogenic mechanisms associated with the circuitry connectivity, electrophysiological alterations, and molecular characteristics are investigated related to the frontal lobe in adult male mice following unilateral injection of blood in the medial prefrontal cortex (mPFC). It is demonstrated that depression is a specific neurological complication in the unilateral hematoma model of the mPFC, and the ventral tegmental area (VTA) shows a higher percentage of connectivity disruption compared to the lateral habenula (LHb) and striatum (STR). Additionally, long‐range projections originating from the frontal lobe demonstrate higher damage percentages within the connections between each region and the mPFC. mPFC neurons reveal reduced neuronal excitability and altered synaptic communication. Furthermore, transcriptomic analysis identifies the involvement of the Janus Kinase‐Signal Transducer and Activator of Transcription (JAK‐STAT) signaling pathway, and targeting the JAK‐STAT pathway significantly alleviates the severity of depressive symptoms. These findings improve the understanding of post‐hemorrhagic depression and may guide the development of efficient treatments.

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Intersection of Sex and Depression: Pathogenesis, Presentation, and Treatments

Frohman,

Nnah,

Tsirka

2023

Handbook of Experimental Pharmacology

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In vivo serotonin 1A receptor hippocampal binding potential in depression and reported childhood adversity

Abstract: This peer-reviewed article has been accepted for publication but not yet copyedited or typeset, and so may be subject to change during the production process. The article is considered published and may be cited using its DOI.

Cited by 8 publications

References 85 publications

Functional Dimerization of Serotonin Receptors: Role in Health and Depressive Disorders

Functional Dimerization of Serotonin Receptors: Role in Health and Depressive Disorders

Unraveling the Pathogenesis of Post‐Stroke Depression in a Hemorrhagic Mouse Model through Frontal Lobe Circuitry and JAK‐STAT Signaling

Intersection of Sex and Depression: Pathogenesis, Presentation, and Treatments

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